RESUMO
OBJECTIVE: To assess the relationship between mouth breathing and growth disorders among children and teenagers. DATA SOURCE: Search on MEDLINE database, over the last 10 years, by using the following terms: "mouth breathing", "adenotonsilar hypertrophy", "allergic rhinitis", "sleep disturbance" AND "growth impairment", "growth hormone", "failure to thrive", "short stature", or "failure to thrive". DATA SUMMARY: A total of 247 articles were identified and, after reading the headings, this number was reduced to 45 articles, whose abstracts were read and, of these, 20 were deemed important and were included in the review. In addition of these articles, references mentioned in them and specific books on mouth breathing deemed important were included. Hypertrophy of palatine and/or pharyngeal tonsils, whether associated with allergic rhinitis, as well as poorly controlled allergic rhinitis, are the main causes of mouth breathing in children. Respiratory sleep disorders are frequent among these patients. Several studies associate mouth breathing with reduced growth, as well as with reduced growth hormone release, which are reestablished after effective treatment of mouth breathing (clinical and/or surgical). CONCLUSIONS: Mouth breathing should be considered as a potential cause of growth retardation in children; pediatricians should assess these patients in a broad manner.
Assuntos
Transtornos do Crescimento/etiologia , Respiração Bucal/complicações , Criança , Transtornos do Crescimento/fisiopatologia , Humanos , Respiração Bucal/fisiopatologia , Obstrução Nasal/complicações , Obstrução Nasal/fisiopatologia , Rinite/complicações , Transtornos do Sono-Vigília/complicações , Transtornos do Sono-Vigília/fisiopatologiaRESUMO
Introdução: decidiu-se organizar este trabalho pelo pressuposto de que é necessário todos os cirurgiõesdentistas se familiarizarem com a estrutura e alterações na anatomia oral desde a infância, com atenção à possibilidade da hipertrofia da adenóides (HA) e a síndrome da apnéia obstrutiva do sono(SAOS) estar presente. Objetivo: observar por meio da revisão de literatura se existe correlação entre a hipertrofia das adenoides e apneia do sono em crianças e qual o tratamento adotado. Material e Métodos: foram feitas pesquisas indexadas nas bases de dados: LILACS, MEDLINE, PubMed, Cochrane, Web of Science e SciELO, no período de janeiro de 2014 a agosto de 2018. Resultados: somente 32 pesquisas foram inclusas na revisão de literatura porque estavam de acordo com os critérios de inclusão. Conclusão: de acordo com a literatura, os autores concluíram que há correlação entre a hipertrofia das glândulas adenoides e a apneia do sono em crianças. A hipertrofia se apresenta como a principal causa da síndrome da apneia obstrutiva do sono em pacientes pediátricos e seu tratamento poderá ser cirúrgico, pela remoção das glândulas adenoides, medicamentoso ou ortodôntico.(AU)
Introduction: It was decided to organize this work on the assumption that it is necessary for all dental surgeons to familiarize themselves with the structure and alterations in oral anatomy from childhood, with attention to the possibility of adenoid hypertrophy (AH) and obstructive sleep apnea syndrome (OSAS) to be present. Objective: to observe in the literature review if the correlation between adenotonsillar hypertrophy and sleep apnea in children was verified and which treatment were adopted. Material and Methods: the following databases were searched: LILACS, MEDLINE, PubMed, Cochrane, Web of Science and SciELO, from January 2014 to August 2018. Results: only 32 articles were included in this literature review because they met all defined inclusion criteria. Conclusion: according the literature, the authors concluded that there is a correlation between hypertrophy of the adenoid glands and apnea of the sleep in children. Hypertrophy presents as the main cause of obstructive sleep apnea syndrome in pediatric patients and its treatment may be surgical, removal of the adenoid, drug or orthodontic.(AU)
Assuntos
Tonsila Faríngea , Polissonografia , Apneia Obstrutiva do SonoRESUMO
Abstract Objective: To assess the relationship between mouth breathing and growth disorders among children and teenagers. Data source: Search on MEDLINE database, over the last 10 years, by using the following terms: "mouth breathing", "adenotonsilar hypertrophy", "allergic rhinitis", "sleep disturbance" AND "growth impairment", "growth hormone", "failure to thrive", "short stature", or "failure to thrive". Data summary: A total of 247 articles were identified and, after reading the headings, this number was reduced to 45 articles, whose abstracts were read and, of these, 20 were deemed important and were included in the review. In addition of these articles, references mentioned in them and specific books on mouth breathing deemed important were included. Hypertrophy of palatine and/or pharyngeal tonsils, whether associated with allergic rhinitis, as well as poorly controlled allergic rhinitis, are the main causes of mouth breathing in children. Respiratory sleep disorders are frequent among these patients. Several studies associate mouth breathing with reduced growth, as well as with reduced growth hormone release, which are reestablished after effective treatment of mouth breathing (clinical and/or surgical). Conclusions: Mouth breathing should be considered as a potential cause of growth retardation in children; pediatricians should assess these patients in a broad manner.
Resumo Objetivo: Avaliar a relação entre respiração oral e distúrbios do crescimento entre crianças e adolescentes. Fonte de dados: Busca na base de dados do MEDLINE, nos últimos 10 anos, com o emprego dos seguintes termos: "mouth breathing" ou "adenotonsilar hypertrophy", ou "allergic rhinitis" ou sleep disturbance" AND "growth impairment" ou "growth hormone" ou "failure to thrive" ou "short stature" ou "failure to thrive". Síntese dos dados: Foram identificados 247 artigos, que após a leitura dos títulos foram reduzidos a 45, cujos resumos foram lidos e desses 20 foram considerados de importância e integraram a revisão. Além desses, referências por eles citadas e livros-texto específicos sobre respiração oral considerados importantes foram incluídos. A hipertrofia de tonsilas palatinas e/ou faríngeas, associada ou não à rinite alérgica, assim como a rinite alérgica mal controlada, é a principal causa de respiração oral na criança. Distúrbios respiratórios do sono são frequentes entre esses pacientes. Vários estudos associam a respiração oral à redução do crescimento, bem como à redução de liberação de hormônio do crescimento, que são restabelecidos após o tratamento efetivo da respiração oral (clínico e/ou cirúrgico). Conclusões: A respiração oral deve ser cogitada como possível causa de retardo de crescimento em crianças e cabe ao pediatra a tarefa de investigar esses pacientes de forma mais abrangente.
Assuntos
Humanos , Criança , Transtornos do Crescimento/etiologia , Respiração Bucal/complicações , Transtornos do Sono-Vigília/complicações , Transtornos do Sono-Vigília/fisiopatologia , Obstrução Nasal/complicações , Obstrução Nasal/fisiopatologia , Rinite/complicações , Transtornos do Crescimento/fisiopatologia , Respiração Bucal/fisiopatologiaRESUMO
Abstract Introduction: Adenoid hypertrophy is a condition that presents itself as the chronic enlargement of adenoid tissues; it is frequently observed in the pediatric population. The Ugrp2 gene, a member of the secretoglobin superfamily, encodes a low-molecular weight protein that functions in the differentiation of upper airway epithelial cells. However, little is known about the association of Ugrp2 genetic variations with adenoid hypertrophy. Objective: The aim of this study is to investigate the association of single nucleotide polymorphisms in the Ugrp2 gene with adenoid hypertrophy and its related phenotypes. Methods: A total of 219 children, comprising 114 patients suffering from adenoid hypertrophy and 105 healthy patients without adenoid hypertrophy, were enrolled in this study. Genotypes of the Ugrp2 gene were determined by DNA sequencing. Results: We identified four single nucleotide polymorphisms (IVS1-189G>A, IVS1-89T>G, c.201delC, and IVS2-15G>A) in the Ugrp2 gene. Our genotype analysis showed that the Ugrp2 (IVS1-89T>G) TG and (c.201delC) CdelC genotypes and their minor alleles were associated with a considerable increase in the risk of adenoid hypertrophy compared with the controls (p = 0.012, p = 0.009, p = 0.013, and p = 0.037, respectively). Furthermore, Ugrp2 (GTdelCG, GTdelCA) haplotypes were significantly associated with adenoid hypertrophy (four single nucleotide polymorphisms ordered from 5′ to 3′; p = 0.0001). Polymorfism-Polymorfism interaction analysis indicated a strong interaction between combined genotypes of the Ugrp2 gene contributing to adenoid hypertrophy, as well as an increased chance of its diagnosis (p < 0.0001). In addition, diplotypes carrying the mutant Ugrp2 (c.201delC) allele were strongly associated with an increased risk of adenoid hypertrophy with asthma and with allergies (p = 0.003 and p = 0.0007, respectively). Conclusion: Some single nucleotide polymorphisms and their combinations in the Ugrp2 gene are associated with an increased risk of developing adenoid hypertrophy. Therefore, we tried to underline the importance of genetic factors associated with adenoid hypertrophy and its related clinical phenotypes.
Resumo Introdução: A adenoide ou hipertrofia de tonsila faríngea é uma condição que se apresenta como o aumento crônico de tecidos linfoides na rinofaringe e é frequentemente observada na população pediátrica. O gene Ugrp2, um membro da superfamília da secretoglobina, codifica uma proteína de baixo peso molecular que funciona na diferenciação das células epiteliais das vias aéreas superiores. No entanto, pouco se sabe sobre a associação de variações genéticas do Ugrp2 com hipertrofia de tonsila faríngea. Objetivo: Investigar a associação de polimorfismos de nucleotídeos únicos no gene Ugrp2 com hipertrofia de tonsila faríngea e seus fenótipos relacionados. Método: Foram incluídos no estudo 219 crianças, 114 pacientes com hipertrofia de tonsila faríngea e 105 saudáveis. Os genótipos do gene Ugrp2 foram determinados por sequenciamento de DNA. Resultados: Identificamos quatro polimorfismos de nucleotídeo único (IVS1-189G>A, IVS1-89T>G, c.201delC, e IVS2-15G>A) no gene Ugrp2. Nossa análise genotípica mostrou que os genótipos Ugrp2 (IVS1-89T>G) TG e (c.201delC) CdelC e seus alelos menores foram associados a um aumento considerável no risco de HA em comparação com os controles (p = 0,012, p = 0,009, p = 0,013 e p = 0,037, respectivamente). Além disso, os haplótipos Ugrp2 (GTdelCG, GTdelCA) foram significativamente associados com hipertrofia de tonsila faríngea (quatro polimorfismos de nucleot' ordenados de 5' a 3'; p = 0,0001). A análise de interação polimorfismo-polimorfismo indicou uma forte interação entre genótipos combinados do gene Ugrp2 que contribuiu para hipertrofia de tonsila faríngea, bem como uma chance maior de seu diagnóstico (p < 0,0001). Além disso, os diplótipos que transportam o alelo mutante Ugrp2 (c.201delC) foram fortemente associados a um risco aumentado de hipertrofia de tonsila faríngea com asma e com alergias (p = 0,003 e p = 0,0007, respectivamente). Conclusão: Alguns polimorfismos de nucleotídeo único e suas combinações no gene Ugrp2 estão associados a um risco aumentado de desenvolver hipertrofia de tonsila faríngea. Portanto, tentamos enfatizar a importância dos fatores genéticos e fenótipos clínicos associados a essa hipertrofia.
Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Tonsila Faríngea/patologia , Citocinas/genética , Polimorfismo de Nucleotídeo Único/genética , Proteínas Supressoras de Tumor/genética , Fenótipo , Estudos de Casos e Controles , Predisposição Genética para Doença , Frequência do Gene , Genótipo , Hipertrofia/genéticaRESUMO
INTRODUCTION: Adenoid hypertrophy is a condition that presents itself as the chronic enlargement of adenoid tissues; it is frequently observed in the pediatric population. The Ugrp2 gene, a member of the secretoglobin superfamily, encodes a low-molecular weight protein that functions in the differentiation of upper airway epithelial cells. However, little is known about the association of Ugrp2 genetic variations with adenoid hypertrophy. OBJECTIVE: The aim of this study is to investigate the association of single nucleotide polymorphisms in the Ugrp2 gene with adenoid hypertrophy and its related phenotypes. METHODS: A total of 219 children, comprising 114 patients suffering from adenoid hypertrophy and 105 healthy patients without adenoid hypertrophy, were enrolled in this study. Genotypes of the Ugrp2 gene were determined by DNA sequencing. RESULTS: We identified four single nucleotide polymorphisms (IVS1-189G>A, IVS1-89T>G, c.201delC, and IVS2-15G>A) in the Ugrp2 gene. Our genotype analysis showed that the Ugrp2 (IVS1-89T>G) TG and (c.201delC) CdelC genotypes and their minor alleles were associated with a considerable increase in the risk of adenoid hypertrophy compared with the controls (p=0.012, p=0.009, p=0.013, and p=0.037, respectively). Furthermore, Ugrp2 (GTdelCG, GTdelCA) haplotypes were significantly associated with adenoid hypertrophy (four single nucleotide polymorphisms ordered from 5' to 3'; p=0.0001). Polymorfism-Polymorfism interaction analysis indicated a strong interaction between combined genotypes of the Ugrp2 gene contributing to adenoid hypertrophy, as well as an increased chance of its diagnosis (p<0.0001). In addition, diplotypes carrying the mutant Ugrp2 (c.201delC) allele were strongly associated with an increased risk of adenoid hypertrophy with asthma and with allergies (p=0.003 and p=0.0007, respectively). CONCLUSION: Some single nucleotide polymorphisms and their combinations in the Ugrp2 gene are associated with an increased risk of developing adenoid hypertrophy. Therefore, we tried to underline the importance of genetic factors associated with adenoid hypertrophy and its related clinical phenotypes.
Assuntos
Tonsila Faríngea/patologia , Citocinas/genética , Polimorfismo de Nucleotídeo Único/genética , Proteínas Supressoras de Tumor/genética , Estudos de Casos e Controles , Pré-Escolar , Feminino , Frequência do Gene , Predisposição Genética para Doença , Genótipo , Humanos , Hipertrofia/genética , Masculino , FenótipoRESUMO
ABSTRACT INTRODUCTION: Adenoid hypertrophy may play a role in velopharyngeal closure especially in patients with palatal abnormality; adenoidectomy may lead to velopharyngeal insufficiency and hyper nasal speech. Patients with cleft palate even after repair should not undergo adenoidectomy unless absolutely needed, and in such situations, conservative or partial adenoidectomy is performed to avoid the occurrence of velopharyngeal insufficiency. Trans-oral endoscopic adenoidectomy enables the surgeon to inspect the velopharyngeal valve during the procedure. OBJECTIVE: The aim of this study was to assess the effect of transoral endoscopic partial adenoidectomy on the speech of children with repaired cleft palate. METHODS: Twenty children with repaired cleft palate underwent transoral endoscopic partial adenoidectomy to relieve their airway obstruction. The procedure was completely visualized with the use of a 70° 4 mm nasal endoscope; the upper part of the adenoid was removed using adenoid curette and St. Claire Thompson forceps, while the lower part was retained to maintain the velopharyngeal competence. Preoperative and postoperative evaluation of speech was performed, subjectively by auditory perceptual assessment, and objectively by nasometric assessment. RESULTS: Speech was not adversely affected after surgery. The difference between preoperative and postoperative auditory perceptual assessment and nasalance scores for nasal and oral sentences was insignificant (p = 0.231, 0.442, 0.118 respectively). CONCLUSIONS: Transoral endoscopic partial adenoidectomy is a safe method; it does not worsen the speech of repaired cleft palate patients. It enables the surgeon to strictly inspect the velopharyngeal valve during the procedure with better determination of the adenoidal part that may contribute in velopharyngeal closure.
Resumo Introdução: A hipertrofia da adenoide pode desempenhar um papel no fechamento velofaríngeo, especialmente em pacientes com anormalidade palatal; a adenoidectomia pode levar à insuficiência velofaríngea e fala hipernasal. Os pacientes com fenda palatina, mesmo após a correção, não devem ser submetidos a adenoidectomia, exceto quando absolutamente necessário e, em tais situações, a forma conservadora ou parcial é realizada para evitar a ocorrência de insuficiência velofaríngea. A adenoidectomia endoscópica transoral permite ao cirurgião inspecionar a válvula velofaríngea durante o procedimento. Objetivo: O objetivo deste estudo foi avaliar o efeito da adenoidectomia parcial endoscópica transoral na fala de crianças submetidas à correção de fenda palatina. Método: Um total de 20 crianças com fenda palatina previamente corrigida, foi submetida a adenoidectomia parcial endoscópica transoral, para desobstrução das vias aéreas,. O procedimento foi completamente visualizado com o uso de um endoscópio de 4 mm e ângulo de 70º; a parte superior da adenoide foi removida com uma cureta para adenoide e fórceps St. ClaireThompson, enquanto a parte inferior foi conservada para manter a competência velofaríngea. Avaliações da fala foram realizadas nos períodos pré e pós-operatório, de forma subjetiva pelaavaliação perceptivo-auditiva, e objetiva pela avaliação nasométrica. Resultados: A fala não foi prejudicada após a cirurgia. A diferença entre os escores da avaliação perceptivo-auditiva e nasalância para as sentenças nasais e orais nos períodos pré e pós-operatório foi insignificante (p = 0,231, 0,442, 0,118, respectivamente). Conclusões: A adenoidectomia parcial endoscópica transoral é um método seguro, e não piora a fala dos pacientes com fenda palatina operada. Ela permite que o cirurgião inspecione rigorosamente a válvula velofaríngea durante o procedimento, com melhor determinação da parte adenoide que pode contribuir para o fechamento velofaríngeo.
Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Qualidade da Voz , Adenoidectomia/métodos , Fissura Palatina/cirurgia , Tonsila Faríngea/patologia , Resultado do Tratamento , Obstrução das Vias Respiratórias/cirurgia , Contraindicações , Hipertrofia/cirurgiaRESUMO
INTRODUCTION: Adenoid hypertrophy may play a role in velopharyngeal closure especially in patients with palatal abnormality; adenoidectomy may lead to velopharyngeal insufficiency and hyper nasal speech. Patients with cleft palate even after repair should not undergo adenoidectomy unless absolutely needed, and in such situations, conservative or partial adenoidectomy is performed to avoid the occurrence of velopharyngeal insufficiency. Trans-oral endoscopic adenoidectomy enables the surgeon to inspect the velopharyngeal valve during the procedure. OBJECTIVE: The aim of this study was to assess the effect of transoral endoscopic partial adenoidectomy on the speech of children with repaired cleft palate. METHODS: Twenty children with repaired cleft palate underwent transoral endoscopic partial adenoidectomy to relieve their airway obstruction. The procedure was completely visualized with the use of a 70° 4mm nasal endoscope; the upper part of the adenoid was removed using adenoid curette and St. Claire Thompson forceps, while the lower part was retained to maintain the velopharyngeal competence. Preoperative and postoperative evaluation of speech was performed, subjectively by auditory perceptual assessment, and objectively by nasometric assessment. RESULTS: Speech was not adversely affected after surgery. The difference between preoperative and postoperative auditory perceptual assessment and nasalance scores for nasal and oral sentences was insignificant (p=0.231, 0.442, 0.118 respectively). CONCLUSIONS: Transoral endoscopic partial adenoidectomy is a safe method; it does not worsen the speech of repaired cleft palate patients. It enables the surgeon to strictly inspect the velopharyngeal valve during the procedure with better determination of the adenoidal part that may contribute in velopharyngeal closure.
Assuntos
Adenoidectomia/métodos , Obstrução das Vias Respiratórias/cirurgia , Fissura Palatina/cirurgia , Qualidade da Voz , Tonsila Faríngea/patologia , Criança , Pré-Escolar , Contraindicações , Feminino , Humanos , Hipertrofia/cirurgia , Masculino , Resultado do TratamentoRESUMO
OBJECTIVE: To evaluate otolaryngologic findings in obese prepubertal children with sleep-disordered breathing. METHODS: We prospectively evaluated 29 obese children referred by pediatric endocrinologist, complaining of snoring and without a history of nasal surgery or removal of the palatine tonsils and/or adenoids. Patients underwent ear, nose and throat (ENT) examination, endoscopy, measurements of weight, height, calculation of body mass index (BMI), assessment of BMI z-score and polysomnography, from which were divided into two groups: those with obstructive sleep apnea syndrome (nine children) and those with primary snoring (20 children). Then we proceeded to the statistical analysis of the data collected. RESULTS: The groups did not differ in age, gender, weight, height, BMI and BMI z-score. Among the findings of the ENT examination, the adenoid size was the only one that differed between the groups (p = 0.01). CONCLUSION: The evaluation of the adenoid size is an important in obese children with symptoms of sleep-disordered breathing and is related to the presence of obstructive sleep apnea syndrome.
Assuntos
Tonsila Faríngea/patologia , Obesidade/epidemiologia , Síndromes da Apneia do Sono/epidemiologia , Ronco/epidemiologia , Fatores Etários , Índice de Massa Corporal , Brasil , Criança , Estudos de Coortes , Feminino , Humanos , Hipertrofia/epidemiologia , Hipertrofia/patologia , Incidência , Masculino , Obesidade/diagnóstico , Otolaringologia/métodos , Polissonografia/métodos , Prognóstico , Estudos Prospectivos , Medição de Risco , Síndromes da Apneia do Sono/diagnóstico , Ronco/diagnósticoRESUMO
Aim: To evaluate if the constricted airway passage, measured by the nasopharyngeal (NP) and oropharyngeal (OP) width, has a correlation to anterior open bite. Methods: Lateral cephalometric radiographs of 43 patients with anterior open bite (26 with mixed dentition and 17 with permanent dentition) and 30 patients with overbite (15 with mixed dentition and 15 with permanent dentition) were obtained from de Department of Pediatric Dentistry and Orthodontics of the Federal University of Rio de Janeiro for examination. Eight patients with syndromes were excluded from study. Cephalometric measurements were carried out using Dolphin Imaging & Management SolutionsTM software (Chatsworth, CA, USA). Measures of NP and OP were evaluated according to the McNamaras soft tissue analysis and were correlated with the presence of open bite or overbite. Students t test and chi-square were used to assess statistical differences in continuous and dichotomic variables, respectively. Kruskal-Wallis test was employed to compare multiple variables. Results: Open bite patients showed significant decreased mean NP and OP values compared to overbite patients. Lack of labial seal was observed in all open bite patients. When patients with mixed and permanent dentitions were analyzed separately, the mean NP value was still significantly smaller in the open bite group. However, the mean OP values were smaller in the open bite group in both dentitions analysis, but were not statistically different. Conclusions: All patients with anterior open bite had reduced NP and OP measures compared to overbite patients, in spite of dentition.
Assuntos
Nasofaringe , Mordida Aberta , OrofaringeRESUMO
La adenoidectomía con técnica de electrocoagulación-succión bajo control visual es un procedimiento cada vez más utilizado para el tratamiento de hipertrofia obstructiva de las adenoides, dada su comprobada efectividad en cuanto a la precisión y extensión completa en la remoción del tejidoadenoideo, su baja complejidad técnica, rapidez y seguridad al minimizar riesgos. En este estudio se evalúan diferentes aspectos de esta técnica tales como: el tiempo quirúrgico del procedimiento, el sangrado transoperatorio y la incidencia de complicaciones en las primeras semanas del postoperatorio. Esta técnica quirúrgica es la que utilizamos en la actualidad en el Servicio deOtorrinolaringología del Hospital Universitario San Ignacio en Bogotá.
Visually controlled suction-cautery adenoidectomy is the most common technique to perform adenoidectomy in developed countries, due to its proven effectiveness in removing enlarged adenoid tissue, its low technical complexity, and decrease in operating time, trans-operative bleeding and higher safety rate. The present prospective study evaluates different outcomes when using this surgical technique, such as duration of the procedure, intra-operative bleeding and incidence of complications. This technique is the one currently used by the authors at San Ignacio University Hospital in Bogota.