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SUMMARY OBJECTIVE: Noise-induced hearing loss is a preventable form of hearing loss that has serious social and economic impacts. This study aimed to investigate the protective effect of berberine, a potent antioxidant and anti-inflammatory agent, against Noise-induced hearing loss. METHODS: After applying distortion product otoacoustic emission, 28 female Sprague-Dawley rats were randomly divided into four groups. Group 1 was designated as acoustic trauma group, and rats in this group were exposed to white noise for 12 h at an intensity of 4 kHz 110 dB sound pressure level. Group 2 was the control group. Group 3 was designated as the berberine group, and 100 mg/kg of berberine was administered to rats in this group by intragastric lavage for five consecutive days. Group 4 was designated as the acoustic trauma+berberine group. distortion product otoacoustic emission was repeated on the 6th day of the study and cochlear tissues of rats were dissected for histopathological and immunohistochemical analyses after sacrificing rats. RESULTS: The distortion product otoacoustic emission results showed a significant decrease in signal-noise ratio values at higher frequencies in rats of the trauma group compared to those in other groups. Acoustic trauma caused severe histopathological impairment at cochlear structures together with severe 8-hydroxy-2-deoxyguanosine expression. Rats in the acoustic trauma+berberine group showed mild histopathological changes with mild 8-hydroxy-2-deoxyguanosine expression and better signal-noise ratio values. CONCLUSION: The histopathological and audiological findings of this experimental study showed that berberine provides protection in Noise-induced hearing loss and may have the potential for use in acoustic trauma-related hearing losses.

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Hearing loss induced by chemotherapy and acoustic trauma is mainly associated with two factors, free radical formation and apoptosis pathway activation. Despite numerous efforts on reducing the effects of these factors, no definite strategy is still determined to interfere with and control these processes. In recent studies, various protective agents, including antioxidants have been used on animal models, to inhibit the formation of free radicals thus improving hearing loss.In this review article we will discuss the role of traditional herbal medicine in treatment of noise/drug induced hearing loss, focusing on medicinal plants' active substances,as well as their mechanisms of action in reducing or preventing the formation of free radicals thus increasing the rate of survival of cochlea cells. Data have been gathered since year 2000, from scientific publications including the following keywords: deafness, drug toxicity, acute trauma, medicinal herbs and oxidative stress. The study includes all herbs and medicinal plants that have been experimentally used in studies on animal models and clinical trials. The results from these studies indicate the effectiveness of most of these herbs and their active substances through their antioxidative properties. Medicinal plants reported in this review can thus be considered as effective remedies intreating noise/drug induced hearing loss,yet further studies need to be done.

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INTRODUCCIÓN: El uso frecuente de reproductores de archivos de música y la intensidad del volumen son factores de riesgo para el desarrollo de hipoacusia. OBJETIVO: Validar el Cuestionario de Tamizaje Auditivo Escolar (CUTAE) para identificar alteraciones auditivas en adolescentes usuarios de reproductores de archivos música comprimida (RPAMC). MÉTODO: Se estudiaron adolescentes usuarios de RPAMC, sin hipoacusia ni patología de oído medio. Se aplicó el CUTAE y se realizó audiometría. Se determinó reproducibilidad (coeficiente correlación intraclase-CCI), consistencia interna (alfa de Cronbach), validez de apariencia (técnica Delphi), validez concurrente CUTAE-audiometría (correlación de Pearson) y validez predictiva (regresión múltiple) del cuestionario. RESULTADOS: Se evaluaron 59 adolescentes (118 oídos), 66 % del sexo femenino, con edad promedio fue de 13 años; 90 oídos con parámetros normales, 18 con umbral menor de 20 dB con morfología de trauma acústico (TA) en la frecuencia de 6 KHz y 10 con TA. El cuestionario tuvo CCI de 0.788, alfa de Cronbach de 0.807, correlación de Pearson de 0.290 a 0.368 (p < 0.05); las variables predictivas fueron horas de uso del dispositivo, dificultad para escuchar a las personas (p < 0.05) y tipo de zumbido (p = 0.07). CONCLUSIÓN: El CUTAE tiene propiedades clinimétricas para considerarlo una prueba de tamizaje en la detección de alteraciones auditivas en adolescentes usuarios de RPAMC. INTRODUCTION: Frequent use of audio file players and volume intensity are risk factors for the development of hypoacusis. OBJECTIVE: To validate the school-age hearing screening questionnaire (CUTAE, by its Spanish acronym) for hearing disorders detection in teenage users of compressed audio file players (CAFP). METHODS: Adolescent CAFP users without hypoacusis or middle ear pathology were studied. The CUTAE was applied and audiometry was carried out. Reproducibility (intraclass correlation coefficient-ICC), internal consistency (Cronbach's alpha), face validity (Delphi technique), CUTAE-audiometry concurrent validity (Pearson's correlation) and predictive validity (multiple regression) of the questionnaire was assessed. RESULTS: Fifty nine adolescents (118 ears), 66% females, average age of 13 years, were assessed. Ninety ears had normal parameters, 18 showed a threshold decrease < 20 dB, with morphology associated with acoustic trauma (AT) at 6 kHz and 10 with AT. The questionnaire had an ICC of 0.788, a Cronbach alpha-value of 0.807, Pearson's correlation values of 0.290 to 0.368 (p < 0.05); the predictive variables were usage hours, difficulty hearing others (p < 0.05) and type of buzzing (p = 0.07). CONCLUSION: The CUTAE has adequate clinimetric properties to be considered as a screening test in the detection of hearing disorders in adolescent users of CAFP.

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La sociedad del siglo XXI se caracteriza por un gran desarrollo de la ciencia y las tecnologías y, esto entre otras causas, ha generado un uso indiscriminado de dispositivos de audio que a su vez traen consigo contaminación sonora y repercusiones negativas en la salud del hombre. El objetivo general de esta investigación fue determinar la discapacidad auditiva producida por el uso de dispositivos de audio, entre jóvenes y adolescentes. Se realizó estudio observacional, descriptivo y prospectivo de los pacientes con sintomatología audiológica, que asistieron a las consultas de Otocirugía y Audiología del Hospital Faustino Pérez de Matanzas, entre enero del 2014 a febrero del 2015, y que cumplieron los criterios de inclusión, exclusión y salida, además de ajustarse a las consideraciones éticas sobre el tipo de estudio. Se midieron las variables: clínico epidemiológicas, tiempo de uso del dispositivo, grado de lesión, síntomas audiológicos y subjetivos asociados. El grupo más afectado fue el de 20 a 24 años. Los audífonos pequeños generaron mayor daño auditivo, así como la exposición al ruido durante más de 60 min de forma continua y a altas intensidades. Síntomas de la esfera psicoafectiva como la irritabilidad y el insomnio se expresaron con elevada incidencia. Después de ser diagnosticados y tratados, las secuelas audiológicas persistieron necesitando, en algunos casos, la rehabilitación protésica. La educación otoaudiológica es un pilar indispensable en la prevención del trauma acústico inducido por ruidos. Se ofertaron plegables educativos para generalizar los resultados en el nivel primario de atención.

The XXI century society is characterized by a great development of sciences and technologies and this, among other things, has generated an indiscriminate use of audio devices bringing with them a sound contamination and negative repercussion on people´s health. The general aim of this research was determining the hearing disability due to the use of audio devices by young people and teenagers. We carried out a prospective, descriptive, observational study of the patients with audiological symptomatology who assisted the Otosurgery and Audiology consultations of the Hospital Faustino Perez of Matanzas, in the period from january 2014 to february 2015 and fulfilled the inclusion, exclusion and exit criteria, and also adjusted to ethical considerations on the kind of study. The easured variables were: the clinical-epidemiological ones, time of device use, lesion level, associated audiological and subjective symptoms. The most affected age group was the 20-24 years one. The small audiphones are the ones generating more auditory damage, and also the exposition to noise during more than 60 minutes, in a continuous form and at high intensities. There they were appreciated symptoms of the psycho-affective sphere like irritability and insomnia expressed with a high incidence. After being diagnosed and treated, audiological sequels persisted, needing, in some cases, prosthetic rehabilitation. Oto-audiological education is an unavoidable pillar in preventing the noise-induced acoustical trauma. Educative leaflets were given to generalize the outcomes at the primary health care level.

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BACKGROUND: Noise-induced hearing loss has increased due to factors such as industrialization. It is estimated that one third of the world's population suffers from some degree of hearing loss caused by exposure to high-intensity noise. Exposure to noise can cause disease of various ear structures, especially destruction of outer hair cells, causing varying degrees of hearing lossObjective: To describe the audiological findings in a group of subjects who were exposed to a source of fireworks explosion in the state of Tlaxcala Mexico. METHODOLOGY: We carried out an audiometric study in eight patients admitted to CENIAQ-INR who were exposed to a firecracker explosion. In each subject, airway with conventional pure tone audiometry from 125 to 8000 Hz was assessed using a clinical audiometer (model 622, Minimate, Madsen) Clinical case: Hearing loss at all frequencies was found in all eight patients, from mild to severe in both ears. Audiogram showed decreases from 4000 Hz, diagnosing third-degree acoustic trauma in all patients. CONCLUSIONS: The main symptom was reported by patients with tinnitus. Other scenarios in which patients report the presence of tinnitus are acoustic trauma due to use of audio players in symphony orchestra musicians and detonating military firearms. Audiometric assessment is recommended after an explosive accident as an accurate method to determine if there is any hearing impairment.

Antecedentes: la pérdida auditiva inducida por ruido se ha incrementado debido a factores como la industrialización. Se estima que un tercio de la población mundial padece algún grado de hipoacusia causada por exposición a ruidos de alta intensidad. La exposición al ruido puede afectar diferentes estructuras del oído y destruir las células ciliadas externas, que provocan diferentes grados de hipoacusia. Objetivo: describir los hallazgos audiológicos encontrados en un grupo de personas expuestas a una fuente de explosión en el estado de Tlaxcala, México. Metodología: estudio transversal, descriptivo, con muestreo censal efectuado en ocho pacientes ingresados al Centro Nacional de Investigación y Atención de Quemados del Instituto Nacional de Rehabilitación, expuestos a una explosión de pólvora. En cada sujeto se evaluó la vía aérea con audiometría de tonos puros, convencional, de 125 a 8000 Hz. Se utilizó un audiómetro clínico marca Madson, modelo Midimate 622, de dos canales y audífonos THD 39. Casos clínicos: en los 8 pacientes se encontró hipoacusia en todas las frecuencias, de media a severa en ambos oídos. Las audiometrías tuvieron caídas a partir de los 4000 Hz, en todos los pacientes se diagnosticó trauma acústico de tercer grado. Conclusiones: el principal síntoma referido por los pacientes fue el acúfeno, otros estudios donde los pacientes refieren acúfeno son, en el trauma acústico por uso de reproductores de audio, en músicos de orquesta sinfónica y en militares por detonación de arma de fuego. Para determinar de manera certera si existe alguna disfunción auditiva posterior a un accidente explosivo se recomienda la valoración audiométrica.

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The aim of this study was to measure the frequency of hearing loss in a sample of typical public high-school students exposed to recreational noise, and determine associated risk factors. The sample was made up of 214 teenagers from a high-school in Mexico City; subjects were selected randomly per strata. We applied a questionnaire to identify risk factors for hearing loss and performed a battery of audiologic tests consisting of otoscopy, tympanometry, and pure-tone audiometry. The mean age of the sample was 16 ± 1.07 years; 73 percent were male and 27 percent, female. Hearing loss was found in 21 percent of students. The main hearing loss-related risk factor was exposure to recreational noise: frequent attendance at discotheques and pop-music concerts; use of personal stereos; and noise exposure in school workshops. The high frequency of hearing loss in high school students from one Mexico City school (nearly one fifth of the sample) was found to be related to noise exposure mainly during recreational activities.

El objetivo de este estudio fue medir la frecuencia de alteraciones auditivas en una muestra de escolares de educación media superior expuestos a ruido recreativo y determinar algunos factores de riesgo asociados. La muestra estuvo constituida por 214 adolescentes de una escuela de la Ciudad de México. Los sujetos fueron seleccionados al azar por medio de una computadora. Se aplicaron cuestionarios con el objeto de identificar los factores de riesgo para alteraciones auditivas y se les practicaron diversos estudios audiológicos consistentes en: otoscopía, timpanometría y una audiometría a tonos puros. La edad media de la muestra fue de 16 ± 1,07 años, 73 por ciento fueron del sexo masculino y 27 por ciento femenino. Se encontraron alteraciones auditivas en 21 por ciento de los estudiantes. Los principales factores de riesgo asociados a alteraciones auditivas fueron: exposición al ruido recreativo al asistir a discotecas, conciertos de música popular, el uso de equipos de sonido personales y la exposición al ruido en los talleres escolares. Se halló una alta frecuencia (casi una quinta parte) de alteraciones auditivas en alumnos de educación media superior asociada a la presencia de ruido recreativo excesivo.

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Studies carried out by Brainstem Evoked Auditory Potentials (BEAP) in Noise-Induced Hearing Loss (NIHL) workers show different results in relation to neuronal involvement, not involving bus drivers as study object. AIM: to use BEAP in a prospective case/control clinical study to check whether or not there is neural auditory pathway involvement in bus drivers with NIHL. MATERIALS AND METHODS: we selected 50 bus drivers between 27 and 40 years with mild to moderate NIHL, and 20 individuals between 29 and 40 years with normal hearing and without prior history of noise exposure. BEAP tests were carried out and the traces were analyzed. RESULTS: in the NIHL group, the auditory thresholds in 3, 4 and 6 kHz were significantly higher in the left ear. In the NIHL group, potentials PI, PIII and/or PV were not present in a small number of the individuals; we observed a statistically significant increase in PI, PIII and PV absolute latencies, (LIP) LIP I-III interpeak latencies, bilaterally and LIP I-V in the left ear. CONCLUSION: in the NIHL group, besides sensorial injury, changes in BEAP latencies suggest an early functional injury of the first auditory pathway afferent neuron.

Estudos realizados com os Potenciais Auditivos Evocados de Tronco Encefálico (PEATE) em trabalhadores com Perda Auditiva Induzida pelo Ruído (PAIR) apresentam resultados díspares em relação ao comprometimento neuronal, além de não contemplar motoristas de ônibus como objeto de estudo. OBJETIVO: Avaliar pelo PEATE, em estudo clínico de série caso/controle, prospectivo, se há comprometimento das vias auditivas neurais em motoristas de ônibus com PAIR. MATERIAL E MÉTODO: Foram selecionados 50 motoristas de ônibus entre 27 e 40 anos portadores de PAIR leve a moderada; e 20 sujeitos entre 29 e 40 anos com audibilidade normal e sem antecedentes de exposição a ruído. Os PEATEs foram realizados e os traçados analisados. RESULTADOS: No grupo PAIR, os limiares auditivos em 3, 4 e 6 kHz foram significativamente maiores na orelha esquerda. No grupo PAIR, os potenciais PI, PIII e/ou PV foram ausentes em uma pequena parcela; foi observado prolongamento estatisticamente significante das latências absolutas de PI, PIII e PV, das latências interpicos (LIP) LIP I-III, bilateralmente e da LIP I-V na orelha esquerda. CONCLUSÃO: No grupo PAIR, além da lesão sensorial, as modificações das latências do PEATE sugerem lesão funcional do primeiro neurônio aferente da via auditiva, de forma precoce.

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El propósito del presente artículo es describir los niveles de ruido generados en una competencia de resistencia aeróbica y se analizan las posibles implicaciones para la salud de la contaminación por ruido. La danza aeróbica es un modo de ejercicio que se ha extendido por todo el mundo, con el fin de posibilitar la práctica de una actividad física que combina música y movimiento. Al incluir el elemento musical en las clases de danza aeróbica, se expone a las personas que practican esta modalidad, al ruido que provoca un alto volumen. Hay investigadores que se han dedicado a estudiar la incidencia del ruido, a indicar los rangos permitidos en lugares de entretenimiento y los gimnasios e informar sobre el peligro de perder momentánea o permanentemente el sentido auditivo al exponerse continuamente a ambientes ruidosos. La presente investigación se realizó en las instalaciones deportivas de la Universidad de Costa Rica, durante un torneo de resistencia aeróbica. Se utilizó un medidor del nivel de sonido marca RadioShack, cat. No. 33-2055. Se encontró que los niveles de sonido utilizados para esta competencia excedieron los 90dB permitidos, ya que oscilaron entre 101 y 119 dB, durante los 120 minutos de duración de la actividad. Se requiere de mayor investigación en esta área en Costa Rica y ejercer un sistema de vigilancia para la contaminación sónica en los gimnasios.

The purpose of the study was to describe noise levels during an aerobics tournament and the potential health implications of noise contamination. Aerobic dance is a worldwide known exercise mode that allows people to practice a physical activity that combines both, music and movement. When music is used in aerobic dance classes people are constantly exposed to the noise produced by high volume of the music. Researchers have studied the incidence of noise to indicate the range of noise permitted in entertainment facilities and fitness centers, and to inform to the population about the hazards of short- and long-term noise exposure on hearing loss. This study took place at the sport facilities of the University of Costa Rica during an aerobics endurance tournament. A RadioShack® (cat. N° 33-2055) noise meter was used to measure noise levels. We found that sound levels for this competition exceeded the permitted 90dB, since these values ranged from 101 to 119 dB during the 120 min duration of the activity. More research in this area is necessary as well as a surveillance system for noise contamination in fitness facilities.

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