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Anim Genet ; 48(5): 600-605, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28736898

RESUMO

Selection affects the patterns of linkage disequilibrium (LD) around the site of a beneficial allele with an increase in LD among the hitchhiking alleles. Comparing the differences in regional LD between pig populations could help to identify putative genomic regions with potential adaptations for economic traits. In this study, using Illumina Porcine SNP60K BeadChip genotyping data from 207 Chinese indigenous, 117 South American village and 408 Large White pigs, we estimated the variation of genome-wide LD between populations using the varld program. The top 0.1% standardized VarLD scores were used as a criterion for all comparisons, and compared with LD blocks, a total of four selection signatures on Sus scrofa chromosome (SSC) 7, 9, 13 and 14 were identified in all populations. These signatures overlapped with quantitative trait loci for linoleic acid content, age at puberty, number of muscle fibers per unit area, hip structure and body weight traits in pigs. Among them, one of the signatures (56.5-56.6 Mb on SSC7) in Large White pigs harbored the ADAMTSL3 gene, which is known to affect body length. The findings of this study seem to point toward recent selection in different pig populations. Further investigations are encouraged to confirm the selection signatures detected by varld in the present study.


Assuntos
Genética Populacional , Desequilíbrio de Ligação , Seleção Genética , Sus scrofa/genética , Alelos , Animais , Cruzamento , China , Genótipo , Haplótipos , Fenótipo , Polimorfismo de Nucleotídeo Único , Análise de Componente Principal , Locos de Características Quantitativas , América do Sul
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