RESUMO
Preliminary results of active immunotherapy ,both in vitro and in vivo, about ascitical Ehrlich carcinoma transplanted in albinic swiss mice are presented. In the in vitro experiment, tumor cells were marked with the immunoglobulin, anti-tumor-associated antigens (TAA) and were coupled to a dinitrophenyl radical (Ig DNP anti-TAA). These cells were meaningfully hindered from migration in presence of swiss albinic mice's splenic cells. These mice were sensibilized to the tumor cells marked with Ig-DNP. The injection of a Ig-DNP anti-TAA 0,3 ml, every third days, intraperitoneal way, in a span of 21 days, in albinical swiss mice with a transplant of 3 X 10(5) Ehrlich carcinoma cells (group A) 24 hours before, constituted the in vivo test. The growth ought to be compared to an Ig-DNP tolerant group (group B), which received equal quantities of tumor cells and followed the same plan of treatment, as well as to another control group transplanted under the same conditions, but with no treatment (group C). Eight days from the experiment, there was a clear difference between group A and groups B and C. The last two groups died from 13th to the 26th day after the transplant. On the contrary, the whore group A continued alive and with no sign of ascitical tumor. Nevertheless, an animal of group A died after the 28th day, due to a solid tumor in the abdominal wall.
Assuntos
Carcinoma de Ehrlich/terapia , Dinitrobenzenos/uso terapêutico , Neoplasias Experimentais/terapia , Nitrobenzenos/uso terapêutico , Animais , Antígenos de Neoplasias/administração & dosagem , Dinitrobenzenos/administração & dosagem , Imunoterapia , Técnicas In Vitro , Injeções Intraperitoneais , Camundongos , Transplante de NeoplasiasRESUMO
Eleven cases of patients bearing basic cellular carcinoma, and one case of patient bearing Kaposi's sarcomatosis, all treated with antibiotics isolated by Goncalves de Lima and Co-workers at the Instituto de Antibióticos, are presented by the authors. Primin, an antibiotic extracted from a vegetal named Miconia sp. (Herb. I.A.-1903) with a 2-metoxi-6-n-pentil-p benzoquinone structure, presented a strong antineoplastic action in the cases treated. Plumbagin isolated from Plumbago scandens in local use, was responsible for a complete healing of the injuries treated. Maytenin extracted from Maytenus sp. (Herb. I.A.-1750) showed less activity than the two previous mentioned, but with a low irritant action and late antineoplastic properties. The authors are going on these experiments. They believe that these antibodies, in local use, may advantageously substitute the surgery and the radiotherapy, meanly in those external ear tumidities and back of the nose, owing to a hurtful action in cartilage, provoked by radiotherapy.