RESUMO
We have theoretically studied new potential candidates of acetylcholinesterase (AChE) inhibitors designed from cardanol, a non-isoprenoid phenolic lipid of cashew Anacardium occidentale nut-shell liquid. The electronic structure calculations of fifteen molecule derivatives from cardanol were performed using B3LYP level with 6-31G, 6-31G(d), and 6-311+G(2d,p) basis functions. For this study we used the following groups: methyl, acetyl, N,N-dimethylcarbamoyl, N,N-dimethylamine, N,N-diethylamine, piperidine, pyrrolidine, and N,N-methylbenzylamine. Among the proposed compounds we identified that the structures with substitution by N,N-dimethycarbamoyl, N,N-dimethylamine, and pyrrolidine groups were better correlated to rivastigmine, and represent possible AChE inhibitors against Alzheimer disease.
Assuntos
Acetilcolinesterase/metabolismo , Inibidores da Colinesterase/química , Inibidores da Colinesterase/farmacologia , Fenóis/química , Fenóis/farmacologia , Doença de Alzheimer/tratamento farmacológico , Anacardium/química , Animais , Elétrons , Electrophorus/metabolismo , Humanos , Modelos Moleculares , Análise de Componente Principal , Relação Estrutura-AtividadeRESUMO
PURPOSE: We evaluated the influence of koilocytosis, and other clinical and pathological variables in the risk of groin metastasis and death in penile cancer patients. MATERIALS AND METHODS: From January 1994 to January 2004, 172 patients with squamous cell carcinoma of the penis were treated at a single cancer center. Of these patients 144 were retrospectively studied to analyze prognostic factors and establish the role of koilocytosis in penile cancer. Univariate and multivariate analyses were performed, and Kaplan-Meier survival curves were generated. RESULTS: A total of 102 patients (71%) underwent groin dissection, of whom 84 (58.3%) had inguinal metastasis. Koilocytosis was present in 91 patients (63.1%) and it was associated with low and moderate primary tumor grade on univariate analysis (p = 0.0005). Although koilocytosis statistically correlated with Jackson stage (p = 0.017) and tumor grade (p = 0.002), it had no impact on disease specific survival (p = 0.912). Metastatic inguinal disease correlated with patient age, Jackson and disease specific survival. Only Jackson stage and inguinal relapse after groin dissection influenced overall survival on multivariate analysis (each p = 0.001). CONCLUSIONS: According to all studied variables only patient age and Jackson stage correlated with an increased risk of groin disease. Koilocytosis was rarely found in high grade penile tumors and it did not correlate with a high risk of metastatic groin disease or death.
Assuntos
Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/secundário , Neoplasias Penianas/mortalidade , Neoplasias Penianas/patologia , Carcinoma de Células Escamosas/patologia , Estudos de Coortes , Virilha , Humanos , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Taxa de Sobrevida , Vacúolos/patologiaRESUMO
This study aims at presenting the analysis of an interaction between a nurse and a patient's family member in which impaired communication was observed. The interpersonal-relationship theoretical framework was used. The patient was young, 20 years old, bore a dead fetus and presented various complications. The interaction took place with her aunt (stepmother) and as to the structure, it was diagnostic, therapeutic and made it possible to establish a proposal of continuous assistance. As to content, it was possible to find the points of support given by family members and identify new facts so that the nursing team could improve the assistance given to the patient.
Assuntos
Barreiras de Comunicação , Enfermagem Familiar , Relações Enfermeiro-Paciente , Relações Profissional-Família , HumanosRESUMO
The aim of this study was to compare information on perioperative Nursing regarding audiovisual (video) and oral resources. 104 patients were registered as subjects and divided in two groups, 54 of them in the oral group and 50 in the video group. Authors concluded that the groups were homogeneous and that there was no significant difference between the two resources used. Independent from the resource used, the responses were qualitatively better. However, regarding perioperative informations, authors spent 10 minutes using the video while oral information lasted 45 minutes. The video unabled verbalization that is characterized by the exposition of methods and reduces the time spent with information.