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1.
Eur J Nutr ; 56(8): 2541-2556, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27535559

RESUMO

PURPOSE: Yerba maté is widely consumed in South America as different beverages, such as maté tea (roasted leaves) and chimarrão (green dried leaves), and linked to health benefits, mainly attributed to chlorogenic acids (CGAs). Health effects of CGAs depend on their bioavailability, but such data are scarce. The aim of this study was to investigate the distribution of CGAs and metabolites in tissues, hepatic and plasmatic kinetic profile and urinary excretion after ingestion of maté tea or 5-caffeoylquinic acid (5-CQA). METHODS: Wistar rats ingested maté tea (MT) or 5-CQA (ST) and were killed after 1.5 h for tissue distribution analysis (pilot study) or at 0.5, 1, 2, 4 and 8 h for liver and plasma kinetics (main experiment). Urine was collected in metabolic cages. Biological samples were analyzed by UPLC-DAD-MS with and without incubation with ß-glucuronidase and sulfatase. RESULTS: CGAs and metabolites were detected in all tissues. Caffeic acid was the main compound in plasma up to 2 h after ingestion of maté tea, while 5-CQA predominated in ST group. Concentration of microbial metabolites increased 4 h after gavage and reached higher amounts in MT plasma and liver, when compared to ST group. Approximately 4.0 % of compounds ingested by MT and 3.3 % by ST were recovered in urine up to 8 h after the gavage. CONCLUSION: The study confirms that not only absorption, but also metabolization of CGAs begins in stomach. There were differences in compounds formed from maté tea or isolated 5-CQA, showing that CGAs profile in food may influence qualitatively and quantitatively the metabolites formed in the body.


Assuntos
Ácido Clorogênico/farmacocinética , Ilex paraguariensis/química , Ácido Quínico/análogos & derivados , Chás de Ervas , Animais , Disponibilidade Biológica , Ácidos Cafeicos/sangue , Ácido Clorogênico/administração & dosagem , Extratos Vegetais/administração & dosagem , Extratos Vegetais/farmacocinética , Folhas de Planta/química , Polifenóis/administração & dosagem , Polifenóis/farmacocinética , Polifenóis/urina , Ácido Quínico/administração & dosagem , Ácido Quínico/farmacocinética , Ratos , Ratos Wistar , América do Sul
2.
Int J Food Sci Nutr ; 65(8): 967-76, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25088791

RESUMO

To investigate the effect of Yerba Mate (YM) aqueous extract intake on the NF-kB pathway and AKT expression in the liver, muscle, and adipose tissue of rats submitted to a high-fat diet (HFD). Male Wistar rats were fed a control (CON) (n = 24) or a HFD (n = 24) for 12 weeks. Afterwards, rats received YM daily (1 g/kg body weight) for 4 weeks. Intake of YM aqueous extract reduced body weight gain (p < 0.05) and total blood cholesterol (p < 0.05) in the HFD group in comparison to the non-treated HFD group. HFD group demonstrated an increased glycemic response at 5 and 10 min after insulin injection. YM decreased the ratio between phosphorylated and total kinase inhibitor of κB (IKK), increased the ratio of phosphorylated to total form of protein kinase B (AKT) and reduced NF-κB phosphorylation in the liver of the HFD group. Our data suggest a beneficial role of YM in improving metabolic dysfunctions induced by HFD.


Assuntos
Dieta Hiperlipídica/efeitos adversos , Ilex paraguariensis , Resistência à Insulina , Fígado/efeitos dos fármacos , NF-kappa B/metabolismo , Extratos Vegetais/farmacologia , Proteínas Proto-Oncogênicas c-akt/metabolismo , Tecido Adiposo/metabolismo , Animais , Glicemia/metabolismo , Colesterol/sangue , Inflamação/etiologia , Inflamação/metabolismo , Inflamação/prevenção & controle , Insulina/metabolismo , Insulina/farmacologia , Fígado/metabolismo , Masculino , Músculos/metabolismo , Obesidade/complicações , Fosforilação , Fitoterapia , Extratos Vegetais/uso terapêutico , Ratos Wistar , Aumento de Peso/efeitos dos fármacos
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