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Environ Sci Pollut Res Int ; 24(7): 6252-6260, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28063087

RESUMO

Lomefloxacin (LOM) is a synthetic antimicrobial from the fluoroquinolone family (FQ) used as a veterinary and human drug. Once in the environment, LOM may pose a risk to aquatic and terrestrial microorganisms due to its antimicrobial activity. This study evaluated the effect of ozonation of LOM (500 µg L-1), the residual antimicrobial activity against Escherichia coli and acute toxicity against Vibrio fischeri. In addition, degradation products were investigated by UHPLC-MS/MS and proposed. Ozonation was carried out varying the applied ozone dose from 0 to 54.0 mg L-1 O3 and pH values of 3, 7, and 11. Ozonation was most efficient at pH 11 and led to 92.8% abatement of LOM in a 9-min reaction time (54.0 mg L-1 O3 applied ozone dose). Ozonation at pH 3 was able to degrade 80.4% of LOM. At pH 7, 74.3% of LOM was degraded. Although the LOM concentration and the antimicrobial activity of the solution dropped as ozone dose increased (antimicrobial activity reduction of 95% at pH 11), toxicity to V. fischeri increased for pH 7 and 11 (i.e., 65% at pH 7 and 75% at pH 11). The reduction in antimicrobial activity may be related to the oxidation of piperazinyl and the quinolone moiety. The formation of intermediates depended on the oxidant (hydroxyl radicals or/and molecular O3) that acted the most in the process.


Assuntos
Fluoroquinolonas/farmacologia , Fluoroquinolonas/toxicidade , Ozônio/química , Poluentes Químicos da Água/farmacologia , Poluentes Químicos da Água/toxicidade , Aliivibrio fischeri/efeitos dos fármacos , Antibacterianos/química , Antibacterianos/farmacologia , Antibacterianos/toxicidade , Fluoroquinolonas/química , Concentração de Íons de Hidrogênio , Radical Hidroxila/química , Oxirredução , Soluções , Poluentes Químicos da Água/química
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