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Neuropharmacology ; 62(1): 518-26, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21945413

RESUMO

Epidemiological data indicate that early stress increases vulnerability to psychiatric disorders, including anxiety and depression. In the present study we sought to investigate the long-term behavioral and neurochemical consequences of increased and sustained corticosterone levels induced by a 24 h bout of maternal deprivation (DEP) imposed on postnatal day 11 (DEP11). As adults, animals were exposed to the elevated plus maze for assessment of anxiety-like behavior and corticosterone response to this challenge, or decapitated for determination of monoamines and amino acid neurotransmitters content in the hippocampus by HPLC method. The results showed that DEP11 male and female rats displayed increased time in the central hub of the maze and more risk assessment behavior, reflecting increased anxiety-like behavior; in addition, these animals continuously secreted corticosterone in response to the behavioral test until the latest time-point, e.g., 60 min post-stress. In males, maternal deprivation increased aspartate and glutamate levels and reduced taurine levels compared to non-deprived (NDEP) rats. DEP11 females displayed reduced noradrenaline, aspartate and GABA levels compared to NDEP counterparts. These results indicate that maternal deprivation at 11 days of age produced changes in hippocampal neurotransmission that may mediate the increased anxiety-like behavior observed in male and female deprived rats. This article is part of a Special Issue entitled 'Anxiety and Depression'.


Assuntos
Ansiedade/etiologia , Hipocampo/crescimento & desenvolvimento , Hipocampo/fisiopatologia , Estresse Psicológico/complicações , Estresse Psicológico/patologia , Transmissão Sináptica/fisiologia , Fatores Etários , Animais , Animais Recém-Nascidos , Ansiedade/sangue , Monoaminas Biogênicas/metabolismo , Cromatografia Líquida de Alta Pressão , Corticosterona/sangue , Modelos Animais de Doenças , Eletroquímica , Feminino , Hipocampo/metabolismo , Masculino , Privação Materna , Aprendizagem em Labirinto , Neurotransmissores/metabolismo , Ratos , Ratos Wistar , Fatores Sexuais , Estatísticas não Paramétricas , Estresse Psicológico/sangue , Estresse Psicológico/etiologia
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