1.
Metallomics
; 7(5): 743-7, 2015 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25860559
RESUMO
Disruptions of biometal-Aß(1-40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg(-1), showing potential as an anti-Alzheimer's drug.