RESUMO
Diabetes mellitus (DM) is a worldwide health concern, and projections state that cases will reach 578 million by 2030. Adjuvant therapies that can help the standard treatment and mitigate DM effects are necessary, especially those using nutritional supplements to improve glycemic control. Previous studies suggest creatine supplementation as a possible adjuvant therapy for DM, but they lack the evaluation of potential morphological parameters alterations and tissue injury caused by this compound. The present study aimed to elucidate clinical, histomorphometric, and histopathological consequences and the cellular oxidative alterations of creatine supplementation in streptozotocin (STZ)-induced type 1 DM rats. We could estimate whether the findings are due to DM or the supplementation from a factorial experimental design. Although creatine supplementation attenuated some biochemical parameters, the morphological analyses of pancreatic and renal tissues made clear that the supplementation did not improve the STZ-induced DM1 injuries. Moreover, creatine-supplemented non-diabetic animals were diagnosed with pancreatitis and showed renal tubular necrosis. Therefore, even in the absence of clinical symptoms and unaltered biochemical parameters, creatine supplementation as adjuvant therapy for DM should be carefully evaluated.
Assuntos
Creatina , Diabetes Mellitus Experimental , Animais , Creatina/farmacologia , Creatina/uso terapêutico , Diabetes Mellitus Experimental/tratamento farmacológico , Diabetes Mellitus Experimental/patologia , Suplementos Nutricionais , Rim/patologia , Pâncreas , Ratos , Ratos Wistar , EstreptozocinaRESUMO
This study aimed to determine the proximate composition and cholesterol content in muscular portion of Pacific white shrimp (Litopenaeus vannamei) collected from a shrimp farm located in the state of Rio Grande do Norte, Brazil. The analysis in the muscular portion were performed after cephalothorax and exoskeleton removal. According to the results, the moisture, protein, ash, lipids and cholesterol had an average value of 74.1g 100 g-1, 21.9 g 100 g-1, 1.5g 100g-1, 0.3g 100g-1 and 26.1mg 100g-1, respectively. Comparing the results found on this research to data reported in the literature for other species, it can be observed that the flesh of the shrimp L. vannamei showed a low content of lipids and cholesterol and higher concentrations of protein, representing a wide nutritional value to the product.
O objetivo deste estudo foi determinar a composição centesimal e o teor de colesterol da carne do camarão branco do Pacífico (Litopenaeus vannamei), oriundo de uma fazenda localizada no estado do Rio Grande do Norte, Brasil. As análises na porção muscular do camarão foram realizadas após a retirada do cefalotórax e exoesqueleto. De acordo com os resultados obtidos, os teores de umidade, proteínas, cinzas, lipídios e colesterol apresentaram valores médios de 74,1g 100g-1, 21,9g 100g-1, 1,5g 100g-1, 0,3g 100 g-1 e 26,1mg 100g-1, respectivamente. Comparando-se os resultados da presente pesquisa com os encontrados na literatura para outras espécies, observou-se que a carne de L. vannamei apresentou baixo teor de lipídeos e colesterol e maiores concentrações de proteínas, representando grande valor nutricional para o produto.
RESUMO
This study aimed to determine the proximate composition and cholesterol content in muscular portion of Pacific white shrimp (Litopenaeus vannamei) collected from a shrimp farm located in the state of Rio Grande do Norte, Brazil. The analysis in the muscular portion were performed after cephalothorax and exoskeleton removal. According to the results, the moisture, protein, ash, lipids and cholesterol had an average value of 74.1g 100 g-1, 21.9 g 100 g-1, 1.5g 100g-1, 0.3g 100g-1 and 26.1mg 100g-1, respectively. Comparing the results found on this research to data reported in the literature for other species, it can be observed that the flesh of the shrimp L. vannamei showed a low content of lipids and cholesterol and higher concentrations of protein, representing a wide nutritional value to the product.
O objetivo deste estudo foi determinar a composição centesimal e o teor de colesterol da carne do camarão branco do Pacífico (Litopenaeus vannamei), oriundo de uma fazenda localizada no estado do Rio Grande do Norte, Brasil. As análises na porção muscular do camarão foram realizadas após a retirada do cefalotórax e exoesqueleto. De acordo com os resultados obtidos, os teores de umidade, proteínas, cinzas, lipídios e colesterol apresentaram valores médios de 74,1g 100g-1, 21,9g 100g-1, 1,5g 100g-1, 0,3g 100 g-1 e 26,1mg 100g-1, respectivamente. Comparando-se os resultados da presente pesquisa com os encontrados na literatura para outras espécies, observou-se que a carne de L. vannamei apresentou baixo teor de lipídeos e colesterol e maiores concentrações de proteínas, representando grande valor nutricional para o produto.
RESUMO
The aim of this study was to compare the nutritional status of zinc and copper in patients with and without diabetes submitted to chronic hemodialysis. Thirty-three patients with type 2 diabetes (DM group), 30 nondiabetic patients (NDM group), and 20 healthy individuals (control group) were studied. Plasma, erythrocyte, and urinary zinc and plasma copper were obtained from atomic absorption spectrophotometry and ceruloplasmin by immunonephelometry. The anthropometric parameters were similar among the groups. Plasma zinc was lower and erythrocyte zinc was higher in the DM and NDM groups in relation to the control group. No difference in urinary zinc was observed comparing the groups. Plasma copper was higher in the DM group when compared to the NDM and control groups. Ceruloplasmin was similar in the three groups. Serum urea was a positive independent determinant of plasma zinc concentrations. The determinants of erythrocyte zinc were MAMC midarm muscle circumference and Kt/V dialysis adequacy. The determinants of plasma copper concentration were serum creatinine and serum glucose. The results of this study demonstrate an alteration in the distribution of zinc in patients with chronic kidney disease (CKD) independently of the presence of DM. Also, the status of copper seems not to be influenced by CKD, but only by the metabolic derangements associated with diabetes.
Assuntos
Cobre/metabolismo , Diabetes Mellitus Tipo 2/metabolismo , Falência Renal Crônica/metabolismo , Zinco/metabolismo , Adulto , Idoso , Glicemia/metabolismo , Ceruloplasmina/metabolismo , Cobre/sangue , Creatinina/sangue , Eritrócitos/metabolismo , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Espectrofotometria Atômica , Zinco/sangueRESUMO
The purpose of this study was to identify the effect of oral zinc supplementation in patients with type 1 diabetes (T1DM) on metabolic control and zinc blood concentrations. The sample consisted of 20 patients with T1DM and a control group (n=17). Metabolic control was evaluated by glycemia at fast, 24 h glycosuria, and HbA1c. Zinc concentrations were measured in plasma and erythrocytes. After the first collection of biological material, oral zinc supplementation was initiated and continued for 4 mo in T1MD patients (T1). Daily dosages were established based on Dietary Recommended Intakes (DRIs), considering zinc intake based on data from other studies previously performed with this population. All analyses were repeated after supplementation (T2). Metabolic control was unsatisfactory, with an HbA1c increase at T2. There was no difference in zinc concentrations in plasma and erythrocytes between patients with T1DM and control. Zinc concentrations in plasma were within the normal range in T1MD before and after supplementation and the control. Zinc concentrations in erythrocyte presented lower than normal values for all groups. A zinc increase in erythrocyte after supplementation was observed in T1DM patients, although without statistical significance. More studies are needed to confirm oral zinc supplementation as nutritional management in diabetes.