1.
Neuroradiology
; 66(7): 1199-1202, 2024 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38668802
RESUMO
Some studies have suggested an inflammatory role of the choroid plexus (CP) in the pathophysiology of multiple sclerosis (MS), but mainly in adult patients. We aimed to evaluate clinical and MRI parameters in patients with pediatric-onset multiple sclerosis (POMS). We included 10 patients with POMS and 16 healthy controls (HC), evaluating clinical and neuroimaging variables (cerebral cortex, CP, deep gray matter structures, and demyelinating lesions). Most patients were girls (80%), with a mean age of 15.3 years. POMS individuals had a higher CP volume (p = 0.012) and lower thalamic volume (p = 0.038) compared to HC. This study shows an enlargement of the CP and lower thalamic volume in POMS patients compared to HC.
Assuntos
Plexo Corióideo , Imageamento por Ressonância Magnética , Esclerose Múltipla , Humanos , Feminino , Masculino , Plexo Corióideo/diagnóstico por imagem , Plexo Corióideo/patologia , Adolescente , Imageamento por Ressonância Magnética/métodos , Esclerose Múltipla/diagnóstico por imagem , Esclerose Múltipla/patologia , Estudos de Casos e Controles , Criança
2.
Neurol Sci
; 44(10): 3731-3734, 2023 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37209286