RESUMO
Burkitt lymphoma (BL) is the second most common AIDS-related lymphoma. Primary sinonasal BL in HIV patients is extremely rare and treatment data in this subset of patients is almost nonexistent. Recently, a few studies reported promising results treating HIV-associate BL with an intensive chemotherapy regimen. The use of highly active antiretroviral therapy (HAARTHAART) concomitantly with chemotherapy seems to improve patient outcomes, but this topic is still controversial due to potential drug interactions. We report a case of a 29-year old woman diagnosed with AIDS presenting with symptoms of chronic sinusitis. Subsequent investigation by CT scan and endoscopic biopsy discovered a sinonasal BL in an early stage. The patient was treated with intensive chemotherapy and HAARTHAART and achieved a complete remission and long-term immunologic recovery. This case report describes a rare entity whose natural history, treatment and prognosis is infrequently characterized in the medical literature.
Assuntos
Síndrome da Imunodeficiência Adquirida/complicações , Síndrome da Imunodeficiência Adquirida/tratamento farmacológico , Terapia Antirretroviral de Alta Atividade , Linfoma de Burkitt/tratamento farmacológico , Linfoma de Burkitt/etiologia , Neoplasias dos Seios Paranasais/tratamento farmacológico , Neoplasias dos Seios Paranasais/patologia , Adulto , Linfoma de Burkitt/diagnóstico por imagem , Linfoma de Burkitt/patologia , Proliferação de Células , Feminino , Humanos , Neoplasias dos Seios Paranasais/diagnóstico por imagem , Seios Paranasais/diagnóstico por imagem , Seios Paranasais/patologia , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
The concentrations of Cu, Zn, Pb, and Cd were determined in the mussel Mytella falcata from the Bacanga River estuary, in order to evaluate the potential role of domestic effluents released "in natura" on the quality of the estuarine environment with consequences to shellfish resources. Cu concentrations ranged from 5.2 mg.g-1 to 13.1 mg.g-1, while Zn concentrations ranged from 49.1 mg.g-1 to 76.3 mg.g-1. Pb and Cd showed concentrations lower than 2 mg.g-1. The results showed low concentrations of Cu, Pb and Cd in the filter-feeding Mytella falcata in the study area in comparison with the maximum values stablished to foods by the Brazilian Government (Decree Law No 55,871). Finally, Zn presented slightly higher values than the maximum ones stablished by the Brazilian government.