RESUMO
Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.
Assuntos
Analgésicos/farmacologia , Anti-Inflamatórios/farmacologia , Dioxóis/farmacologia , Lignanas/farmacologia , Óleo de Gergelim/farmacologia , Ácido Acético/administração & dosagem , Ácido Acético/efeitos adversos , Animais , Carragenina/administração & dosagem , Carragenina/efeitos adversos , Edema/induzido quimicamente , Edema/tratamento farmacológico , Formaldeído/administração & dosagem , Formaldeído/efeitos adversos , Inflamação/tratamento farmacológico , Masculino , Camundongos , Nociceptividade/efeitos dos fármacos , Dor/tratamento farmacológico , Pleurisia/induzido quimicamente , Pleurisia/tratamento farmacológico , Ratos , Ratos Wistar , Testes de Toxicidade AgudaRESUMO
This paper presents a review and analysis of Pharmacist Care as an integrated part of the Primary Health Care System, in which quality use of medicines is directly related to quality health service and to elements for its evaluation. In our country the Basic Health Units represent the main entrance to the public health care system. The pharmaceutical services however are still linked to the care model centered in medical consultation and emergency care, with the pharmacy just satisfying their needs. Provide orientation to the users of a Basic Unit pharmacy is almost impossible because nearly all sore spots of the health system end up at the pharmacy as the final step in the care process. The solution of the problem will not be easy if the present structure of the service is maintained. Great part of the pressure resulting from the demand does not depend on the health service itself but on inclusive social policies with direct impact on the health conditions of the population. Rational use of medicines from the prescriber to the user is fundamental in this specific environment.