RESUMO

Bioactivity-guided fractionation of a CH2Cl2 extract from leaves of Piper hispidum (Piperaceae) yielded a new pyrrolidine amide, N-[7-(3',4'-methylenedioxyphenyl)-2(Z),4(Z)-heptadienoyl] pyrrolidine 1, in addition to two known amides N-[5-(3', 4'-methylenedioxyphenyl)-2(E)-pentadienoyl] pyrrolidine and N-[2-(3', 4'-methylenedioxy-6'-methoxyphenyl)-2(Z)-propenoyl]pyrrolidine. The structure of compound 1 was elucidated by interpretation of spectral data, including ES-MS. Compound 1 showed antifungal activity against Cladosporium sphaerospermum.

Assuntos

Antifúngicos/isolamento & purificação , Plantas/química , Pirrolidinas/isolamento & purificação , Antifúngicos/química , Antifúngicos/farmacologia , Cladosporium/efeitos dos fármacos , Folhas de Planta/química , Pirrolidinas/química , Pirrolidinas/farmacologia , Análise Espectral