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Mater Sci Eng C Mater Biol Appl ; 115: 111057, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32600687

RESUMO

Ethyl ferulate, a phenylpropanoid derived from rice hulls has aroused interest because of its antioxidant, anti-inflammatory and neuroprotective properties. However, it has low solubility in water which compromises the absorption in the gastrointestinal tract, decreases the bioavailability and compromises the reproducibility of the effects in vivo. To increase the solubility of ethyl ferulate, inclusion complexes were obtained by physical mixing, malaxing, lyophilization and spray drying and characterized using thermal analysis, XRD and FTIR. The complexes obtained were evaluated for ethyl ferulate content, stability, dissolution profile and evaluation of anti-inflammatory activity in vivo through carrageenan-induced paw edema model in rats. The inclusion complexes obtained resulted in increased solubility and stability compared to the isolated ethyl ferulate. In addition, the complexes obtained by malaxage, lyophilization and spray drying showed greater inhibition of the edema formation induced by carrageenan compared to ethyl ferulate 100 mg/kg v.o. The inclusion of ethyl ferulate in B-cyclodextrin resulted in the formation of stable inclusion complexes with potent antidematogenic activity possibly attributed to the increased solubility, dissolution profile of the active.


Assuntos
Ácidos Cafeicos/administração & dosagem , Edema/tratamento farmacológico , beta-Ciclodextrinas/química , Animais , Disponibilidade Biológica , Ácidos Cafeicos/química , Ácidos Cafeicos/farmacocinética , Carragenina/efeitos adversos , Modelos Animais de Doenças , Estabilidade de Medicamentos , Edema/induzido quimicamente , Ratos , Solubilidade , Espectroscopia de Infravermelho com Transformada de Fourier , Resultado do Tratamento
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