1.
Org Biomol Chem
; 21(46): 9128-9132, 2023 Nov 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37966723
RESUMO
The remarkable biological activities of γ-lactams have stimulated the search for efficient synthetic methods to achieve these scaffolds. In this work, we have developed a simple one-pot diastereoselective synthesis of new γ-lactams from ketoaziridines with moderate to good yields via the Horner-Wadsworth-Emmons reaction, followed by an intramolecular ester-aziridine cyclization and its opening in situ. Preliminary efforts towards an enantioselective version of this method are also reported.