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1.
Auton Autacoid Pharmacol ; 27(4): 167-71, 2007 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-18076477

RESUMO

1 To evaluate the effect of high spinal cord transection (SCT), between T4 and T5, on the mean arterial pressure (MAP) and heart rate in animals anaesthetized with different anaesthetic agents: ether (n = 12), 20% urethane, 1.2 g kg(-1) (n = 12), 2% tri-bromide-ethanol, 200 mg kg(-1) (n = 12); chloral hydrate and urethane, 75 and 525 mg kg(-1) respectively (n = 12). 2 In the animals anaesthetized with ether or urethane, SCT caused an immediate major drop in MAP, with hypotension and bradycardia throughout the next 10 min. In the animals anaesthetized with urethane + chloralose or tri-bromide-ethanol, SCT transiently increased MAP with subsequent hypotension and bradycardia. 3 In summary, the haemodynamic changes after complete, high SCT are anaesthetic agent dependent. Further research about the exact mechanisms responsible for these diverse autonomic changes is warranted.


Assuntos
Anestésicos/farmacologia , Pressão Sanguínea/efeitos dos fármacos , Frequência Cardíaca/efeitos dos fármacos , Traumatismos da Medula Espinal/fisiopatologia , Animais , Pressão Sanguínea/fisiologia , Frequência Cardíaca/fisiologia , Masculino , Ratos , Ratos Wistar , Vértebras Torácicas
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