Assuntos

RESUMO

No envelhecimento da pele, as alterações intrínsecas, secundárias à perda da regeneração celular, e extrínsecas, causadas pela exposição à radiação ultravioleta, podem ser observadas e alteram a arquitetura tecidual e as propriedades fisiológicas da pele. Tratamentos que restauram a produção de colágeno e estimulam os fibroblastos a sintetizar e organizar a matriz extracelular são críticos para a morfogênese, angiogênese e cicatrização. Potencial utilização de produtos que estimulam a produção de colágeno, que desempenha papel fundamental na matriz extracelular, representa perspectiva promissora para a melhoria da qualidade da pele e das propriedades mecânicas, introduzindo um novo conceito de abordagem terapêutica no tratamento de alterações causadas pelo envelhecimento da pele

In the skin aging process, both intrinsic alterations, secondary to cell regeneration capacity loss resulting from chronological action, and extrinsic alterations, caused by to ultraviolet radiation exposure, can be observed. Treatments that restore collagen production and stimulate fibroblasts to synthesize and organize extracellular matrix are critical for morphogenesis, angiogenesis, and skin healing. Potential uses of products that stimulate collagen production, a component that plays a fundamental role in the extracellular matrix, represents a promising perspective for improving skin quality and its mechanical properties by introducing a new concept of therapeutic approach when treating changes caused by skin aging

RESUMO

A qualidade e a função da pele reduzem-se drasticamente com a idade devido ao envelhecimento cronológico, ao fotoenvelhecimento, aos fatores ambientais e às deficiências hormonais. O declínio dos níveis de estrógeno na menopausa tem papel importante na atrofia cutânea, redução do colágeno, perda de elasticidade e deficiência da cicatrização de feridas. Pesquisas têm demonstrado os efeitos benéficos do estrogênio tópico, que teria ação mais localizada na pele sem efeitos colaterais sistêmicos. O objetivo deste estudo foi revisar a literatura pertinente ao assunto, demonstrando que o uso do estrogênio tópico pode ser uma alternativa segura e eficaz para o tratamento da pele de mulheres na perimenopausa.

Skin quality and function drastically reduces with age due to chronological aging, photoaging, environmental factors and hormonal deficiencies. Decreased menopausal estrogen levels play a role in cutaneous atrophy, collagen and water content, loss of elasticity, skin wrinkling and deficiency of wound healing. Much research has been done to elucidate the beneficial effects of topical estrogen, which would have a more localized action on the skin without systemic side effects. The objective of this study was to review the relevant literature, demonstrating that this may be a safe and effective alternative for the treatment of women's skin in perimenopause

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RESUMO

Color differences in skin are due to the amount and distribution of epidermal melanin. The number of melanocytes is almost the same in all skin types, but higher phototypes exhibit more melanocytes, which produce more melanin and melanosomes that are individually distributed throughout the keratinocyte layers. This characteristic ensures a natural, significant photoprotection in darker skins. Asians are a population with various skin phototypes, ranging from type III to IV Fitzpatrick's classification in Chinese and Japanese to type IV and V in Indian and Pakistani people. Asian skin tends to present postinflammatory hyperpigmentation, melasma, lentigines and freckles, nevus of Ota, and Hori nevus. The main skin diseases reported in Asians are acne, atopic dermatitis, and viral infections. Wrinkles and skin thickness, early signs of aging in Caucasians, are less evident in Asian skin. However, pigmentary changes occur earlier. Additionally, this ethnic population is increasing worldwide. The aim of this study is to show the importance of studying the characteristics of Asian skin for the better management of skin diseases in this population, which are being increasingly observed in doctor's offices. Based on a broad review of the medical literature, we report the characteristics of Asian skin, as well as some dyschromias and common skin disorders in this ethnic group. The objective of the article is to study the characteristics of Asian skin and differences in relation to other ethnic groups to achieve improved clinical and cosmetic management of diseases and other skin disorders. This article will discuss the concept of beauty in different ethnic groups, treatments with lasers and other light sources, and cosmiatric treatments in Asian skin. An extensive review of the literature was performed using the databases Scielo and Bireme, from Medline and Lilacs sources, over the last 50 years. The keywords used were as follows: Asian skin, ethnic skin, melanin. Due to the peculiarities of each ethnic group, this article demonstrates the importance of studying the characteristics of Asian skin to elucidate improved cosmiatric approaches for these patients.

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RESUMO

OBJECTIVE: The aim of this study was to establish the lipid profile of female patients with acne in the Acne-in-Adult-Women Ambulatory Care Clinic in order to observe the prevalence of dyslipidemia in those patients. METHODS: This is a retrospective transversal study that evaluated the medical records of 416 patients who attended at the Acne-in-Adult-Women Ambulatory Care Clinic, at the Dermatology Department, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil, in the year 2012. Relevant data included age and clinical classification of acne. The lipid profile was analyzed according to the results of laboratory tests ordered during outpatient visits, which included total and fractionated cholesterol levels and triglycerides. RESULTS: The epidemiological study sample was of 219 patients, with ages ranging from 21 to 61 years (mean of 32.23 years). The predominant clinical grade was papule-pustule acne (grade II) with 156 patients (71%). Regarding the lipid profile of the patients, there was a high increase in total cholesterol levels in 17.35% of the cases. High-density lipoprotein levels were low in 11.42% of the patients, with normal prevalence in 194 subjects. Low-density lipoprotein levels were normal in most patients (60.27%). Very-low-density lipoprotein values were normal in almost all patients (94.06%) and increased in only 13 patients (5.94%). Only 18 patients presented high levels of triglycerides (8.22%). CONCLUSION: The conclusion was that patients with grades II and III acne are more likely to have total cholesterol and low-density lipoprotein altered. A correct and early diagnosis can be an important measure for the prevention of the metabolic syndrome in these patients.

RESUMO

Acne in adult women is a hard-to-manage frequent disease with many relapse cases. It mostly interferes with quality of life and causes major social and metabolic losses for patients. This is a transversal retrospective study and the aim was to standardize the research on circulating androgenic hormone levels and to detect hyperandrogenic states early, showing the frequency and the pattern of the altered hormones, useful resources to correctly evaluate each patient. In this study 835 women above 15 years of age, with acne or aggravation cases, were analyzed. The aim was to verify the percentage of androgen examinations with levels above normal. The levels of the hormones dehydroepiandrosterone sulfate, dehydroepiandrosterone (DHEA), dehydrotestosterone, androstenedione and total testosterone were measured in all patients. The evaluation of the hormone profile showed that 54.56% of the patients had hyperandrogenism, and the levels of DHEA were most frequently elevated. Therefore, in the face of the importance of hyperandrogenism in the pathogenesis of acne, standardizing the research of the hormone profile is paramount for the treatment and control of relapses in case of a surge of acne breakouts during a woman's adult life.

Assuntos