RESUMO

A series hydroxycinnamic and gallic acids and their derivatives were studied with the aim of evaluating their in vitro antioxidant properties both in homogeneous and in cellular systems. It was concluded from the oxygen radical absorbance capacity-fluorescein (ORAC-FL), 1,1-diphenyl-2-picrylhydrazyl (DPPH), and cyclic voltammetry data that some compounds exhibit remarkable antioxidant properties. In general, in homogeneous media (DPPH assay), galloyl-based cinnamic and benzoic systems (compounds 7-11) were the most active, exhibiting the lowest oxidation potentials in both dimethyl sulfoxide (DMSO) and phosphate buffer. Yet, p-coumaric acid and its derivatives (compounds 1-3) disclosed the highest scavenging activity toward peroxyl radicals (ORAC-FL assay). Interesting structure-property- activity relationships between ORAC-FL, or DPPH radical, and redox potentials have been attained, showing that the latter parameter can be a valuable antioxidant measure. It was evidenced that redox potentials are related to the structural features of cinnamic and benzoic systems and that their activities are also dependent on the radical generated in the assay. Electron spin resonance data of the phenoxyl radicals generated both in DMSO and phosphate buffer support the assumption that radical stability is related to the type of phenolic system. Galloyl-based cinnamic and benzoic ester-type systems (compounds 9 and 11) were the most active and effective compounds in cell-based assays (51.13 ± 1.27% and 54.90 ± 3.65%, respectively). In cellular systems, hydroxycinnamic and hydroxybenzoic systems operate based on their intrinsic antioxidant outline and lipophilic properties, so the balance between these two properties is considered of the utmost importance to ensure their performance in the prevention or minimization of the effects due to free radical overproduction.

Assuntos

RESUMO

BACKGROUND: Type II diabetes mellitus causes metabolic changes that may lead to early menopause and worsen climacteric symptoms. OBJECTIVES: To determine the risk factors for type II diabetes mellitus and assess the impact of this disease on the age of menopause and on climacteric symptoms. METHODS: A total of 6079 women aged between 40 and 59 years from 11 Latin American countries were requested to answer the Menopause Rating Scale and Goldberg Anxiety-Depression Scale. RESULTS: The prevalence of diabetes was 6.7%. Diabetes mellitus was associated with arterial hypertension (odds ratio (OR) 4.49; 95% confidence interval (CI) 3.47-5.31), the use of psychotropic drugs (OR 1.54; 95% CI 1.22-1.94), hormonal therapy (OR 1.46; 95% CI 1.11-1.92), ≥ 50 years of age (OR 1.48; 95% CI 1.17-1.86), overweight or obese (OR 1.47; 95% CI 1.15-1.89), and waist circumference ≥ 88 cm (OR 1.32; 95% CI 1.06-1.65). Factors associated with lower risk of diabetes were the use of hormonal contraceptives (OR 0.55; 95% CI 0.35-0.87), alcohol (OR 0.73; 95% CI 0.54-0.98) and living in cities > 2500 meters above sea level (OR 0.70; 95% CI 0.53-0.91) or with high temperatures (OR 0.67; 95% CI 0.51-0.88). In turn, diabetes tripled the risk of menopause in women under 45 years of age. Diabetes did not increase the risk of deterioration of quality of life due to climacteric symptoms. CONCLUSION: Menopause does not increase the risk of type II diabetes mellitus. Diabetes is associated with early menopause in women under 45 years of age.

Assuntos

RESUMO

Eighty two patients from two public rural outpatient clinics were interviewed about referrals requested during June 1991, the unresolved proportion after six months, the alternative ways used to solve the health problems and their perception about this issue. A total of 95 referrals were requested in June in these clinics (4 every 100 consultations) and information about 85 was obtained. The frequency varies from 10% in the women's program, most of the referrals are directed to surgery, respiratory diseases and dermatology, in the adult's program, to radiology, gastroenterology and a wide variety of specialties. Six months later almost all the referrals had an appointment at the reference hospital. In spite of this, 20 patients did not receive the information and five sought a solution with private physicians. Of the 65 remaining patients, 12.3% lost their appointment due to diverse reasons such as preferring private physicians, oblivion or lack of money. Fifty seven patients went to the reference hospital. Thirty eight percent of these felt that their health problem had not been solved at the moment of the study, because they were still in treatment, were waiting a bed in surgery, the results of some laboratory tests were delayed or they perceived bad treatment. It is concluded that only half of the patients referred to specialists, felt that their health problem had been solved six months later.

Assuntos

RESUMO

A sample of 823 adult morbidity consultations in four rural medical centers in the VI Region in Chile were studied according to age and group of diagnosis. There was a reduction in the number of consultations with age. The following were the most frequent diagnoses: respiratory disorders 17.3%, infections and parasitic infestation 10.2%, circulatory diseases 10.6%, gastrointestinal diseases 9.8%, genitourinary diseases 8.9%, musculoskeletal disorders 8.6% and mental illnesses 8.0%. No differences were found between this pattern of morbidity and that found in similar studies in urban areas. Important differences were found between the rural centres included in the study and these should be analysed in more detail, as they may reveal different risk factors for these populations.

Assuntos

Assuntos