Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
Pharmacol Biochem Behav ; 180: 83-91, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30910666

RESUMO

Administering clomipramine during the early days of life induced several behavioral and neurochemical alterations in adult male rats, which resemble major depression disorder. The alterations included poor sexual performance, which is considered a reward-seeking behavior regulated by dopaminergic system. Given that estrogen receptors are expressed in different areas of the brain involved in regulating reproductive behavior, motivation and mood. The objective of this study was to analyze the effect of a non-selective dopamine agonist (apomorphine) on sexual incentive motivation in rats exposed to clomipramine (CMI) in the neonatal period. In addition, we evaluated the expression of mRNA ERα and ERß in nucleus accumbens (NAcc) and septum of CMI rats. We found that only a few rats subjected to neonatal CMI treatment performed mounts, intromissions and ejaculations. Also, those rats spent less time exploring the sexual incentive zone and had lower preference scores; this effect was reverted by administering 0.1 mg/kg of apomorphine. Finally, the CMI rats presented higher levels of mRNA ERα and ERß, only in septum area. These data indicate that neonatal treatment with CMI altered the expression of mRNA ERα and ERß in the septum, which participates in regulating the motivational component of sexual behavior.


Assuntos
Apomorfina/farmacologia , Clomipramina/farmacologia , Copulação/efeitos dos fármacos , Agonistas de Dopamina/farmacologia , Receptor alfa de Estrogênio/genética , Receptor beta de Estrogênio/genética , Inibidores Seletivos de Recaptação de Serotonina/farmacologia , Septo do Cérebro/efeitos dos fármacos , Animais , Animais Recém-Nascidos , Apomorfina/administração & dosagem , Clomipramina/administração & dosagem , Agonistas de Dopamina/administração & dosagem , Feminino , Masculino , Motivação/efeitos dos fármacos , Núcleo Accumbens/efeitos dos fármacos , Núcleo Accumbens/metabolismo , RNA Mensageiro/genética , Ratos , Ratos Wistar , Recompensa , Septo do Cérebro/metabolismo , Inibidores Seletivos de Recaptação de Serotonina/administração & dosagem , Transdução de Sinais/efeitos dos fármacos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA