Assuntos
Líquido Amniótico/química , Ruptura Prematura de Membranas Fetais , Doenças do Prematuro/diagnóstico , Fosfatidilgliceróis/análise , Diagnóstico Pré-Natal/métodos , Síndrome do Desconforto Respiratório do Recém-Nascido/diagnóstico , Feminino , Humanos , Doença da Membrana Hialina/diagnóstico , Recém-Nascido , Gravidez , Segundo Trimestre da Gravidez , Terceiro Trimestre da Gravidez , Estudos Prospectivos , VaginaAssuntos
Amebíase , Doenças dos Genitais Femininos , Adolescente , Adulto , Feminino , Humanos , Pessoa de Meia-Idade , GravidezRESUMO
PIP: Prior to scheduled hysterectomies, 5 women ranging in age from 38 to 49 were injected with Tritium labeled D-norgestrel in an effort to discover the take-up site or sites of the compound. Efforts were then made to correlate the data with blood levels, urinary excretion, and menstrual cycle phase. In all cases it was found that the drug showed an initial preference for the endometrium, regardless of cycle phase. Nevertheless, in all the genetal tissues, deposits were quantitatively larger during the estrogen phases than during the progesterone phase. In the fatty tissues, however, the deposits seemed to increase during the 2nd phase of the cycle. 8 hours after the injection most radioactivity was found in blood corresponding to free steroids. In contrast after 128 hours most was present in congenital steroids. Urinary excretion was faster during the estrogen phase of the cycle, at which time 46.5% of the injected doses was eliminated in the 1st 80 hours; in the progesterone phase 35.12% was eliminated in 80 hours. The largest deposits of D-norgestrel in the genital tissues during the proliferative phases might have been due to the increased number of receptive sites present at that time. The breakup of the deposits during the luteal phase could possibly have been due to the subsequent occupation of the sites by endogenous progesterone. The contraceptive effect of continuous microdoses of the drug could be due to its selective take-up in the endometrium. Such take-up was not observed in similar studies done with progesterone and chlormadinone.^ieng