RESUMO

The SO2 capture performance of MIL-53(Al)-TDC was optimised by confining a small amount of MeOH within its pores (MeOH@MIL-53(Al)-TDC). In comparison with fully activated MIL-53(Al)-TDC, MeOH@MIL-53(Al)-TDC shows a 39% higher SO2 capture capacity. Monte Carlo simulations revealed that such an enhancement is associated with an increase in the degree of confinement via the SO2 molecules resulting from the formation of a lump (MeOH molecules) in the vicinity of the µ-OH groups.

RESUMO

Metal-organic frameworks MIL-53(Al)-TDC and MIL-53(Al)-BDC were explored in the SO2 adsorption process. MIL-53(Al)-TDC was shown to behave as a rigid-like material upon SO2 adsorption. On the other hand, MIL-53(Al)-BDC exhibits guest-induced flexibility of the framework with the presence of multiple steps in the SO2 adsorption isotherm that was related through molecular simulations to the existence of three different pore opening phases narrow pore, intermediate pore, and large pore. Both materials proved to be exceptional candidates for SO2 capture, even under wet conditions, with excellent SO2 adsorption, good cycling, chemical stability, and easy regeneration. Further, we propose MIL-53(Al)-TDC and MIL-53(A)-BDC of potential interest for SO2 sensing and SO2 storage/transportation, respectively.

RESUMO

The adsorption of sulphur dioxide (SO2) in CAU-10 is obtained with the use of advanced experimental and computational tools to gain insight into the molecular mechanisms responsible for the adsorption of SO2. It is shown that the adsorption by CAU-10 is highly energy efficient and that van der Waals interactions are the driving force that controls adsorption in this system.

RESUMO

The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way toward the extended use of Sc(III)-based MOFs as drug delivery systems (DDSs).

RESUMO

The MOF-type MIL-53(Al)-TDC was demonstrated to be an optimal adsorbent for H2S capture combining an unprecedented uptake at room temperature, excellent cyclability and low-temperature regeneration.

RESUMO

A six-month-old female cat suffered aspiration of an abundant amount of barium sulfate during a radiographic procedure for the diagnosis of megaesophagus. Latero-lateral contrast radiography revealed severe dilation of the thoracic esophagus cranial to the base of the heart. Persistence of the right aortic arch was suspected and later confirmed during corrective surgery. Accumulation of barium sulfate, used as a contrast agent, was clearly observed in the lumen of the bronchi, bronchioles, and alveoli in the radiographic image. Days after the surgery, the animal developed severe respiratory distress, which resulted in death. Cytology results and histology analysis using polarized light demonstrated that the lumen of bronchi, bronchioles, and alveoli exhibited evident histiocytic infiltration with cytoplasm filled by abundant amorphous refractive granular material consistent with barium sulfate. In this report, we describe the anatomical, cytological, histopathological (using polarized light), and x-ray findings of a case of barium sulfate aspiration pneumonia in a cat resulting from the use of this contrast medium for the diagnosis of megaesophagus secondary to persistent right aortic arch.(AU)

Uma gata de seis meses aspirou grande quantidade de sulfato de bário durante procedimento radiográfico para diagnóstico de megaesôfago. Contraste radiográfico látero-lateral revelou dilatação de esôfago torácico até a base do coração. Persistência do arco aórtico direito foi confirmada durante cirurgia corretiva. Acúmulo de sulfato de bário, utilizado como agente de contraste, foi observado no lúmen de brônquios, bronquíolos e alvéolos à imagem radiográfica. Dias após a cirurgia o animal desenvolveu insuficiência respiratória grave e evoluiu para óbito. Resultado de citologia e histologia utilizado luz polarizada demonstrou que lúmen de brônquios, bronquíolos e alvéolos mostraram infiltração histológica com citoplasma cheio de material refratário granular amorfo compatível com sulfato de bário. Nesse relatório, descrevemos achados anatômicos, citológicos, histopatológicos e radiográficos de um caso de pneumonia aspirativa em gata resultante do uso desse meio de contraste para diagnóstico de megaesôfago secundário a persistência do arco aórtico direito.(AU)

Assuntos

RESUMO

A six-month-old female cat suffered aspiration of an abundant amount of barium sulfate during a radiographic procedure for the diagnosis of megaesophagus. Latero-lateral contrast radiography revealed severe dilation of the thoracic esophagus cranial to the base of the heart. Persistence of the right aortic arch was suspected and later confirmed during corrective surgery. Accumulation of barium sulfate, used as a contrast agent, was clearly observed in the lumen of the bronchi, bronchioles, and alveoli in the radiographic image. Days after the surgery, the animal developed severe respiratory distress, which resulted in death. Cytology results and histology analysis using polarized light demonstrated that the lumen of bronchi, bronchioles, and alveoli exhibited evident histiocytic infiltration with cytoplasm filled by abundant amorphous refractive granular material consistent with barium sulfate. In this report, we describe the anatomical, cytological, histopathological (using polarized light), and x-ray findings of a case of barium sulfate aspiration pneumonia in a cat resulting from the use of this contrast medium for the diagnosis of megaesophagus secondary to persistent right aortic arch.(AU)

Uma gata de seis meses aspirou grande quantidade de sulfato de bário durante procedimento radiográfico para diagnóstico de megaesôfago. Contraste radiográfico látero-lateral revelou dilatação de esôfago torácico até a base do coração. Persistência do arco aórtico direito foi confirmada durante cirurgia corretiva. Acúmulo de sulfato de bário, utilizado como agente de contraste, foi observado no lúmen de brônquios, bronquíolos e alvéolos à imagem radiográfica. Dias após a cirurgia o animal desenvolveu insuficiência respiratória grave e evoluiu para óbito. Resultado de citologia e histologia utilizado luz polarizada demonstrou que lúmen de brônquios, bronquíolos e alvéolos mostraram infiltração histológica com citoplasma cheio de material refratário granular amorfo compatível com sulfato de bário. Nesse relatório, descrevemos achados anatômicos, citológicos, histopatológicos e radiográficos de um caso de pneumonia aspirativa em gata resultante do uso desse meio de contraste para diagnóstico de megaesôfago secundário a persistência do arco aórtico direito.(AU)

Assuntos

RESUMO

CO2 capture of InOF-1 was enhanced 3.6-fold, at 1 bar and 30 °C, by confining EtOH within its pores. Direct visualisation by single crystal X-ray diffraction revealed that EtOH divides InOF-1 channels in wide sections separated by "bottlenecks" caused by EtOH molecules bonded to the µ2-OH functional groups of InOF-1.

RESUMO

We assessed the prevalence of infection with Trypanosoma cruzi, parasite genotypes (discrete typing units, DTUs), and the host-feeding sources of domestic and peridomestic Triatoma infestans Klug and Triatoma eratyrusiformis Del Ponte in eight rural communities of the subandean Calchaqui valleys in northwestern Argentina. We sought to analyze their epidemiological role in the context of routine vector surveillance and control actions. Infection with T. cruzi was determined by optic microscopy or polymerase chain reaction (PCR) amplification of the hypervariable region of kinetoplast DNA minicircles. Parasite genotypes were identified through a multi PCR-based strategy. Bloodmeal contents were tested with a direct ELISA assay against nine antisera. Human sleeping quarters (domiciles) and peridomestic dry-shrub fences concentrated most of the T. infestans and T. eratyrusiformis infected with T. cruzi, respectively. The most frequent host-feeding sources of T. infestans were chickens (73.1%) in peridomiciles and humans (73.3%) in domiciles, whereas T. eratyrusiformis fed more often on cavid rodents (92.6%), which thrived in the dry-shrub fences. The main T. cruzi DTU identified in both vectors was T. cruzi I (TcI). Triatoma eratyrusiformis was implicated in the local circulation of TcI among cavies and perhaps mice, but infection with other typically domestic DTUs (TcVI and TcII/TcV/TcVI) indicated overlap between (peri)domestic transmission cycles in both vector species. Because dry-shrub fences were not targeted for routine insecticide spraying, they may act as sources of (peri)domestic reinfestation. Triatoma eratyrusiformis is an emergent secondary vector of T. cruzi and plays a significant role in the local transmission of T. cruzi.

Assuntos

RESUMO

La anemia es la concentración de la hemoglobina por debajo de los valores límites establecidos. Las comunidades indígenas de la etnia Nivaclé que habitan el Chaco paraguayo viven bajo condiciones de extrema pobreza, careciendo de asistencia sanitaria y de programas de control de enfermedades. Este estudio descriptivo de corte transversal realizado de junio de 2001 a marzo de 2002, tuvo como objetivo establecer la prevalencia y distribución de anemia en hombres y mujeres de 15 a 65 años, de la etnia Nivaclé que habitan en el Chaco paraguayo. Se incluyó a todos los indígenas voluntarios sanos presentes en el momento del estudio que aceptaron participar, previo consentimiento informado. La concentración de hemoglobina se determinó en 379 indígenas Nivaclé. La OMS considera que existe anemia en los adultos (a partir de 15 años), cuando la concentración de hemoglobina es inferior a 130 g/L para el sexo masculino y menor a 120 g/l para el femenino. La prevalencia de anemia en mujeres n= 217 fue de 49,8 % (con media hemoglobina de 117,67 ± 12,16 g/L); y en los hombres n= 162 resultó de 33,3 % (promedio de hemoglobina de 132,62 ± 11,65 g/L). La elevada prevalencia de anemia observada, especialmente en mujeres, se debería a una pobre nutrición, lo que conlleva a una mala salud que justifica la incorporación de estrategias de atención primaria de salud que se adapten a la cultura y a las condiciones de estas comunidades.

Assuntos

RESUMO

PURPOSE/METHODS: To report a rare case of a tumor in a conjunctival location, a giant cell collagenoma. Tissue was stained with hematoxylin-eosin, periodic acid-Schiff, and Masson's trichromic stain and studied by immunohistochemistry. RESULTS/CONCLUSION: The clinical and histopathologic features of conjunctival giant cell collagenoma are similar to characteristics of the same tumor occurring in other parts of the body. This is the first report of this tumor in the eye.

Assuntos

RESUMO

PURPOSE/METHODS: To report a rare case of melanocytoma in a choroidal location. The clinical and echographic characteristics were similar to those of a melanoma. The treatment selected in our case was a choroidectomy. Tissue was stained with hematoxylin-eosin, periodic acid-Schiff, Masson's trichromic and immunohistochemistry was performed. RESULTS/CONCLUSIONS: The clinical and histopathologic features of choroidal melanocytoma are similar to the characteristics of a melanocytoma located in other parts of the eye. The differential diagnosis between choroidal melanoma and melanocytoma is very difficult without histopathologic correlation.

Assuntos

RESUMO

Debido a la importancia de la hemoglobina como indicador nutricional, así como su papel en la oxigenación de los tejidos, fue realizado este estudio con el objetivo de observar la existencia o no de alteraciones en los niveles de hemoglobina de individuos fumadores donantes de sangre, de tal manera que dichas alteraciones causadas por el cigarrillo sean consideradas, al evaluar el estado de salud de un individuo fumador, así como en el diagnóstico de las patologías asociadas. Fueron seleccionados 121 varones, aparentemente sanos, fumadores y no fumadores, entre 20 y 60 años de edad, donantes de cinco bancos de sangre de Asunción, Paraguay. Los niveles promedios de hemoglobina en fumadores fueron 150 ± 8 g/L y en los no fumadores 148 ± 9 g/L, no siendo la diferencia significativa (p>0.05); sin embargo dentro del grupo de fumadores, la diferencia fue significativamente mayor en aquellos que fumaban de 11 a 20 cigarrillos /día (152 ± 9 g/L) que en aquellos que fumaban de 1 a 10 cigarrillos /día (148 ± 7 g/L) (p<0.05). Por lo tanto, el nivel medio de hemoglobina se incrementa con el número de cigarrillos consumidos por día. El coeficiente de correlación hallado fue de 0,38 con un nivel de confianza del 95%. Debemos seguir investigando, en nuestra población, la influencia del cigarrillo sobre los parámetros hematológicos, y el efecto que producen dichas alteraciones en el estado de salud de los fumadores.

Due to the important role haemoglobin plays as nutritional marker and in tissue oxygenation, this study was carried out to determine if there are alterations in haemoglobin levels of smoking blood donors. In this way, these alterations caused by cigarettes should be considered when the health status of smoking men is evaluated, as well as in the diagnosis of associated pathologies. One hundred and twenty one male individuals were selected for this study. They were apparently healthy, smoking and non­smoking men, between 20 and 60 years old, blood donors from five blood banks in Asunción, Paraguay. The mean haemoglobin level in smokers was 150 ± 8 g/L and in non­smokers 148 ± 9 g/L. The difference was not significant (p>0.05) but the difference was statistically greater in individuals smoking 11 to 20 cigarettes /day (152 ± 9 g/L) than in those who smoked 1 to 10 cigarettes /day (148 ± 7 g/L) (p<0.05). Thus, the mean value of haemoglobin increases with the number of cigarettes smoked per day. The correlation coefficient was 0.38 with a confidence interval of 95%. Further studies about the influence of cigarettes, the haematological parameters and the effect produced by alterations on the health status of smokers are necessary in this population.

Assuntos

RESUMO

The antipsychotic drugs (APDs) are fundamental tools in current psychiatric practice. A new generation of agents, the atypical APDs, represents an important progress in the treatment of psychotic disorders. Unfortunately, some of them induce excessive body weight gain (BWG), obesity, hyperglycemia and dyslipidemia in the following order: clozapine approximately equal to olanzapine > quetiapine > risperidone > ziprasidone = aripiprazole. Appetite stimulation is probably the main mechanism of BWG and this is strongly correlated with the APD affinity for H1 (histaminergic) and alpha1 (adrenergic) receptors. A composed ratio of the APD affinity for diverse neurotransmitters involved in food intake (FI) regulation correlates with BWG as well. Endocrine/metabolic mechanisms, such as the activation of the hypothalamus-pituitary-adrenal axis, changes in insulin sensitivity (by conventional and atypical agents), hyperprolactinemia and gonadal dysfunction (by conventional APDs and risperidone) may also be involved. Importantly, patients with schizophrenia may have a genetically-based predisposition to appetite dysregulation, insulin resistance and endocrine imbalance involving gonadal steroids. Excessive BWG must be prevented or attenuated by proper drug selection, combining or switching agents, nutritional assistance and physical exercise. Amantadine. metformin and reboxetine proved to significantly lessen APD-induced BWG. Notwithstanding this, novel strategies are necessary to treat this side effect in a clinical population particularly prone to poor compliance and under a high risk of negative drug interaction.

Assuntos

RESUMO

We report a case of endogenous nocardial endophthalmitis in a 32-year-old man with systemic lupus erythematosus. The patient developed pulmonary and ocular disease while on systemic corticosteroid and cyclophosphamide treatment. The intraocular infection progressed to a scleral fistula, and was treated with pars plana vitrectomy, lensectomy, intravitreous and intravenous antibacterial therapy. The diagnosis of Nocardia asteroides was made by isolation and growth of colonies from samples of a vitreous specimen and bronchioloalveolar aspirates. The eye became phthisical, it was eviscerated, and histopathogical examination was carried out.

Se describe un caso de endoftalmitis endógena por nocardia en un varón de 32 años con diagnóstico de lupus eritematoso sistémico. El paciente desarrolló compromiso pulmonar y ocular luego de meses de tratamiento con corticoides y ciclofosfamida. La infección intraocular, de rápida evolución a fístula escleral, recibió tratamiento con vitrectomía, lensectomía y terapia antibacteriana intravítrea y endovenosa. Se aislaroncolonias de Nocardia asteroides a partir de material vítreo y aspirado bronquioloalveolar. El ojo afectado evolucionó a ptisis bulbi y fue posteriormente eviscerado, y se realizó el estudio histopatológico.

Assuntos

RESUMO

We report a case of endogenous nocardial endophthalmitis in a 32-year-old man with systemic lupus erythematosus. The patient developed pulmonary and ocular disease while on systemic corticosteroid and cyclophosphamide treatment. The intraocular infection progressed to a scleral fistula, and was treated with pars plana vitrectomy, lensectomy, intravitreous and intravenous antibacterial therapy. The diagnosis of Nocardia asteroides was made by isolation and growth of colonies from samples of a vitreous specimen and bronchioloalveolar aspirates. The eye became phthisical, it was eviscerated, and histopathogical examination was carried out.(AU)

Se describe un caso de endoftalmitis endógena por nocardia en un varón de 32 años con diagnóstico de lupus eritematoso sistémico. El paciente desarrolló compromiso pulmonar y ocular luego de meses de tratamiento con corticoides y ciclofosfamida. La infección intraocular, de rápida evolución a fístula escleral, recibió tratamiento con vitrectomía, lensectomía y terapia antibacteriana intravítrea y endovenosa. Se aislaroncolonias de Nocardia asteroides a partir de material vítreo y aspirado bronquioloalveolar. El ojo afectado evolucionó a ptisis bulbi y fue posteriormente eviscerado, y se realizó el estudio histopatológico.(AU)

Assuntos

RESUMO

INTRODUCTION: Multiple sclerosis (MS) is considered to be a low prevalence disease in Mexico; its characteristics have been described in isolated studies in small populations concentrated in a single region of the country and using heterogeneous methodological tools. AIMS. In this study, our aim was define the clinical profile and some socio demographic aspects of MS in Mexico using validated homogeneous criteria and tools. PATIENTS AND METHODS: Eight hospitals representing the five most densely populated regions of the country, the north, centre and south of Mexico, took part in the study. Data were obtained through a survey created, validated and published in Spanish (k interobserver 0.73 and k intraobserver 0.76), which consisted of 142 questions arranged in 10 sections and which was applied by 12 neurologists. The procedure was verified with 50 randomly selected surveys. A total of 337 surveys were applied, which were analysed by descriptive statistics using the EPI INFO, version 6.04b, software application. All the patients presented MS that had been clinically defined with the help of paraclinical studies according to Schumaher and Poser's criteria. RESULTS: A sample of 337 patients was studied; 99.1% were mestizos, with an average age of 37 9 years, 69.7% were females and 30.3% males. 95% had access to the Social Security system and 96% had been born in Mexico to Mexican parents. No cases were found among native Mexicans. The clinical profile of the disease did not differ to that reported in other countries; the pattern observed corresponded to that found in northern latitudes. CONCLUSION: This is the first multicentre study carried out in Mexico with a population that is highly representative of the whole country and with a homogeneous methodology.

Assuntos

RESUMO

PURPOSE/METHODS: To report the pathological findings in a case of intravitreous cilia with macular pucker. We considered clinical factors to establish treatment. A pars plana vitrectomy and premacular membrane peeling were performed. Surgical samples were removed and studied with PAS, hematoxylin-eosin, Masson's Trichromic and immunohistochemistry. RESULTS/CONCLUSION: The histopathological examination disclosed the presence of cilia partially surrounded by a cuticle layer and internal limiting membrane with a celullarity increase. Surgical extraction is indicated in those cases in which the intraocular cilia are associated with any surgically treatable process or when it produces ocular inflammation or visual disturbance.

Assuntos

RESUMO

Tratamos 132 mujeres con miomas uterinos durante los últimos 40 meses. Evaluando escala de dolor pélvico, dismenorrea, sangrado anormal, dispareunia y síntomas compresivos. Cuantificamos el volumen inicial del útero. En todas se realizó angiografía hipogástrica y de arterias uterinas (130 bilateral, 2 izquierda), embolización con PVA de 500 micras. Seguimiento clínico y ecográfico mensual los primeros 6 meses y luego cada 3 meses. Se descartó neoplasia cervical e infección silente antes de la embolización. La intervención fue ambulatoria. RESULTADOS. Rango de edades entre 23 y 45 años, paridad promedio 1,6 hijos, 29 por ciento nuliparas, 84 por ciento sufrían algún grado de dolor pélvico crónico, 81 por ciento dismenorrea, 56 por ciento hemorragias anormales, 43 por ciento síntomas compresivos. Después de la embolización mejoró el dolor pélvico en 91 por ciento los primeros 60 días, también mejoría del sangrado anormal den 88 por ciento y de los síntomas compresivos en 95 por ciento los primeros 6 meses. Tres presentaron infección uterina tardía, hasta 4 meses postembolización, una de ellas histerectomizada en otra institución, las otras tratadas por nuestro grupo conservando el útero. 5 pacientes abortaron miomas. Estancia ambulatoria promedio de 4 horas, ninguna permaneció más de 1 día. En 35 por ciento hubo miomectomías previas. Registramos disminución del volumen uterino en 53 por ciento a los 6 meses y 66 por ciento a los 12 meses. CONCLUSIONES. La embolización de miomas uterinos es efectiva y bien tolerada, con baja tasa de complicaciones . Útil para controlar el dolor crónico, hemorragia y dismenorrea

Assuntos

RESUMO

The present review is focused on chronic RV pressure overload or Cor Pulmonale as it may occur in the setting of two distinct disorders: those associated with abnormal pulmonary gas exchange (hypoxemia and/or hypercapnia) where chronic obstructive pulmonary disease (COPD) is the leading cause, and those associated with pulmonary vascular obstruction where primary pulmonary hypertension (PDDH) is the representative example. The clinical curse, prognostic, implications, and therapeutic strategies differ considerably in these two clinical entities. Right ventricular failure (RVF) may adversely influence the natural history and prognosis of patients with diverse cardiopulmonary disorders. It has been long established that right ventricular (RV) ischemia, RV overload, and RV pressure overload, alone or in combination, are the main factors involved in the pathogenesis of RVF. From the pathophysiologic point of view, RVF of COPD is more a congestive type of failure, in which activation of renin-angiotensin system is involved. In PPH, a low cardiac output state is predominant and the precise mechanism of RVF remains unknown. Current evidence in favor of the pathogenetic role of ischemia, adrenergic overdrive, and genetic determination are all reviewed during the course.

Assuntos