RESUMO
This study was conducted to examine the effects of garlic (G), black cumin (BC) and G+BC within the broiler rations, on performance, relative organ weights, intestinal morphology, serum biochemistry and plasma total oxidant/ antioxidant status. Two hundred broilers chicks (Ross 308) were used and they were divided into 4 groups consisting of 5 subgroups of 10 animals each. The trial was ended on the 35th day. No addition was made to the control group ration. 5g / kg garlic (G), 5g / kg black cumin (BC) and 5g / kg G + 5g / kg BC were added to the experimental group rations, respectively. There was no statistical difference among the trial groups in terms of BWG, FI, FCR and relative organ weights (p>0.05). Serum total protein (p 0.05) and albumin (p 0.001) levels were higher in BC and BC +G groups as compared to G and control group. Serum AST activity were lower in G group as compared to control and other experimental groups (p 0.05). On histological examinations, regarding the duodenal epithelium; there was no difference among the trial groups. Hyperemia was observed, especially in the G group, in macroscopic exams of lamina propria and other viticular areas. The lymph follicles were more wide spread in the G + BC, G and BC groups than in the control. The results of the study showed that the combination of BC and G can have beneficial effects, and different doses of G and BC may be used to see positive or negative effects.(AU)
Assuntos
Animais , Alho/efeitos adversos , Alho/química , Nigella sativa , Reações Bioquímicas/análise , Galinhas/anatomia & histologia , Galinhas/fisiologiaRESUMO
This study was conducted to examine the effects of garlic (G), black cumin (BC) and G+BC within the broiler rations, on performance, relative organ weights, intestinal morphology, serum biochemistry and plasma total oxidant/ antioxidant status. Two hundred broilers chicks (Ross 308) were used and they were divided into 4 groups consisting of 5 subgroups of 10 animals each. The trial was ended on the 35th day. No addition was made to the control group ration. 5g / kg garlic (G), 5g / kg black cumin (BC) and 5g / kg G + 5g / kg BC were added to the experimental group rations, respectively. There was no statistical difference among the trial groups in terms of BWG, FI, FCR and relative organ weights (p>0.05). Serum total protein (p 0.05) and albumin (p 0.001) levels were higher in BC and BC +G groups as compared to G and control group. Serum AST activity were lower in G group as compared to control and other experimental groups (p 0.05). On histological examinations, regarding the duodenal epithelium; there was no difference among the trial groups. Hyperemia was observed, especially in the G group, in macroscopic exams of lamina propria and other viticular areas. The lymph follicles were more wide spread in the G + BC, G and BC groups than in the control. The results of the study showed that the combination of BC and G can have beneficial effects, and different doses of G and BC may be used to see positive or negative effects.
Assuntos
Animais , Alho/efeitos adversos , Alho/química , Galinhas/anatomia & histologia , Galinhas/fisiologia , Nigella sativa , Reações Bioquímicas/análiseRESUMO
PURPOSE: Small cell lung cancer (SCLC) has a high relapse rate despite being very chemosensitive. The efficacy of second-line treatment is dismal. Our aim was to evaluate the outcome of second-line treatment. METHODS: We retrospectively assessed data of 120 SCLC patients who failed first-line treatment and received second-line treatment at three medical oncology centers. RESULTS: Median age of group was 58. 82 % had an ECOG PS of 0-1 at the time of relapse. 39 % were at limited stage (LS) at the time of diagnosis. Patients who progressed more than 3 months after first-line therapy were categorized as having platinum-sensitive disease (PSD) (64 %). The number of patients who received platin-based combination treatment was 33 (27 %). The median OS time starting from the initiation of second-line treatment was 7 months. Multivariate analysis identified PS (p = 0.006), extent of disease at diagnosis (0.014) and PSD (0.001) as the independent prognostic factors for survival. Subgroup analyses of the patients with PSD indicated platin rechallenge yields higher progression-free survival, overall survival and overall response rate. CONCLUSION: Patients with good ECOG PS,who have PSD or initially presenting with LS, have a good prognosis and in patients with PSD, platinum-based therapy would be more appropriate.
Assuntos
Antineoplásicos/uso terapêutico , Neoplasias Pulmonares/tratamento farmacológico , Carcinoma de Pequenas Células do Pulmão/tratamento farmacológico , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carboplatina/uso terapêutico , Feminino , Humanos , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Carcinoma de Pequenas Células do Pulmão/patologia , Taxa de Sobrevida , Resultado do TratamentoRESUMO
Turnip (Brassica rapa var. rapa) is one of the main vegetables consumed by people living in Eastern Anatolia in Turkey. In this region, farmers obtain their own seeds for production, which results in considerable morphological variability. We examined the genetic variation and relationships among 11 turnip genotypes sampled from diverse environments of the Erzurum region located in Eastern Anatolia in Turkey. Thirty-two Operon RAPD primers were screened; among them, 20 gave reproducible and clear DNA fragments after amplification. The average polymorphism ratio was 90.4%. The genetic distance between turnip genotypes were found to range from 0.302 to 0.733, indicating high genetic variability. Eleven genotypes were divided into three main clusters in a dendrogram; ETS2 and ETS8 genotypes were the most distant. We conclude that RAPD analysis would be useful for genotyping turnip genotypes.