RESUMO
Participaron del estudio 76 mujeres futbolistas de la región de Valparaíso, las edades fluctuaron entre los 18 y 30 años. Fueron evaluados los equipos femeninos profesionales de los clubes Everton, Santiago Wanderers y San Luis de Quillota, las selecciones de la universidades de Valparaíso, Técnica Federico Santa María y Universidad Viña del Mar. Las posiciones de juego fueron distribuidas en arqueras (n= 8), defensas (n= 25), volantes (n= 24) y delanteras (n= 18). Para la evaluación de la composición corporal se utilizó el protocolo establecido por la International Society for the Advancement of Kinanthropometry. Para determinar el somatotipo de las futbolistas fue utilizado el modelo de Heath & Carter. Se fraccionó el peso corporal total a través del método pentacompartimental diseñado por Kerr. Los resultados demuestran un somatotipo promedio mesomorfo endomorfo, la distribución por equipos evidencia diferencias significativas en el mesomorfismo entre los equipos Everton y Universidad Viña del Mar (p<0,014). Entre las posiciones arquera y delantera existieron diferencias significativas en las variables peso (p<0,030) y endomorfia (p<0,050). No existieron diferencias en el porcentaje de tejido adiposo, tejido muscular, sumatoria de pliegues y estatura por posición de juego. En lo que respecta a la distribución por posición de juego, se evidencia un somatotipo meso endomorfo en las posiciones arquera y defensa, en las posiciones volantes y delanteras se aprecia un somatotipo mesomorfo endomorfo, esto demuestra una diferenciación del somatotipo entre posiciones de juego defensivas y ofensivas encontrando un mayor predominio de la endomorfia en las posiciones defensivas en comparación con las de ataque. Según el método SANOVA se concluye que las futbolistas evaluadas en este estudio presentaron características antropométricas similares, no habiendo diferencias significativas entre equipos universitarios y profesionales, ni por posición de juego.
Seventy-six female football players from the Valparaiso Region. Players´ age fluctuated between 18 and 30 years participated in this research. Female professional teams from Everton, Santiago Wanderers and San Luis de Quillota clubs, as well as the teams from Federico Santa María Technical University and Viña del Mar University were evaluated. Playing positions were: goalkeepers (n= 8), defenders (n= 25), attacking midfielders (n= 24) and strikers (n= 18). To measure body composition the protocol established by the International Society for the Advancement of Kinanthropometry was used, according to the restricted profile described by Drinkwater and Norton & Olds. The Heath and Carter method was used to determine the somatotype of the female football players. Total body mass was divided using Kerr´s Five-Way Fractionation method. Results show an average somatotype of mesomorph and endomorph. In the distribution by teams, the results showed significant differences of mesomorph between the Everton Club and the Viña del Mar University (p<0.014). Between the goalkeepers and the strikers there were significant differences regarding weight (p<0.030) and endomorph (p<0.050). No differences in the percentage of adipose tissue, muscle tissue, the sum of folds and height in relation to playing position were found. Regarding the distribution by playing position, the results showed a meso-endomorph somatotype for the goalkeepers and defenders, and a mesomorph endomorph somatotype for the attacking midfielders and strikers. This reveals a differentiation of somatotypes between offensive and defensive playing positions, finding a higher prevalence of the endomorph somatotype in defensive playing positions compared to the attack positions. Using the SANOVA method, the study concludes that the anthropometric attributes of the female football players evaluated are similar, with no significant differences between university teams and professional teams or by playing position.
Assuntos
Humanos , Feminino , Adolescente , Adulto , Adulto Jovem , Antropometria , Futebol , Somatotipos , ChileRESUMO
El objetivo fundamental de la presente investigación fue determinar el perfil antropométrico y su relación con la capacidad de salto en jugadores de balonmano varones de la región de Valparaíso y de la Selección Chilena, esto en relación a su posición en el campo de juego. Se valoraron 74 jugadores de la categoría cadetes, cuyas edades fluctuaron entre los 14 y los 16 años, pertenecientes a los equipos: Club Italiano Villa Alemana, Club Italiano Quillota, Club Luterano, Club Viña del Mar, Club San José y Selección Chilena. Los resultados arrojaron que en cuanto a las variables antropométricas, la Selección Chilena y el Club Italiano Villa Alemana, son los que poseen los parámetros que más se asemejan a los requeridos a nivel competitivo dentro de esta categoría. Al hacer referencia a las variables antropométricas se estimó que, en todos los grupos estudiados, la masa adiposa se relacionó negativamente con la altura de salto alcanzada. Mientras que la masa muscular presentó una alta correlación con el rendimiento en salto en la mayoría de los equipos. Los índices de correlación evidenciaron que un menor porcentaje de masa grasa y mayor porcentaje de masa muscular favorecen la altura de salto alcanzada en todas las posiciones de juego. Queda de manifiesto que la relación masa adiposa y masa muscular es un indicador importante a la hora de determinar el rendimiento en la capacidad de salto en deportistas con características similares a las de este estudio.
The primary purpose of this research was to determine the relationship between the anthropometric profile and jump capacity of male handball players from the Fifth Region of Chile and the National Handball Team and their specific position in the playing field. In the evaluation 74 handball players participated from the following teams: Club Italiano Villa Alemana, Club Italiano Quillota, Club Luterano, Club Viña del Mar, Club San José and the National Handball Team. Participants were in the cadet category aged 14 16. The results showed that within anthropometric variables, players from the Chilean Handball Team and the Club Italiano Villa Alemana are the closest to fulfilling all the criteria required to reach high competitive levels in this category. In reference to anthropometric variables, fat mass proved to be negatively related to jump height reached in all groups tested, while muscle mass presented significant correlation with the jump capacity in most of the teams. Regarding the somatotype, results obtained agree with the theoretical referents. These establish that handball player's somatotype is more likely to be mesomorph. The correlation indexes demonstrate that a lower fat mass percentage and a higher muscle mass percentage enhance the jump capacity in all playing positions. It is clear now that fat mass and muscle mass are important indicators when determining the jump capacity performance in players with similar characteristics of the ones in this study. This research is important in setting comparative parameters in the selection process and sport specialization regarding anthropometric characteristics and jump capacity according to specific position of handball players in the cadet category.
Assuntos
Humanos , Masculino , Adolescente , Antropometria , Composição Corporal , Somatotipos , Esportes , Desempenho Atlético , Chile , Esportes/fisiologiaRESUMO
El presente artículo es un ensayo desarrollado por cuatro terapeutas ocupacionales que en la actualidad desempeñan sus labores en dos universidades chilenas. Durante una mesa redonda realizada en el III Encuentro de Estudiantes de Terapia Ocupacional en Chile en el año 2014, y desde sus propios desarrollos teóricos, se reúnen para asumir el desafío de explicar por qué es tan difícil definir qué es la Terapia Ocupacional. Así, la discusión comienza con las propuestas realizadas por las mujeres pragmatistas, de principios del siglo XX, y los aportes para comprender los procesos de salud y enfermedad desde una perspectiva holística en contraposición a la visión dicotómica y reduccionista instalada por la ciencia neopositivista. Se prosigue con la propuesta ontológica de Heidegger sobre el Ser y Tiempo para la explicación de la ocupación y la Terapia Ocupacional, asumiendo un vacío ontológico en la historia de la profesión. Posteriormente se presentan los aportes que, desde la Teoría del Actor-red, ayudarían a responder la pregunta inicial, asumiendo que la dificultad estaría en la incapacidad de traducir y enrolar los propios desarrollos teóricos a otros actores. Finalmente se entrega una propuesta de posicionamiento epistemológico desarrollado inicialmente por Humberto Maturana y Francisco Varela, el que deriva hasta el paradigma de la complejidad, definido por Edgar Morin.
This article is the result of an essay developed by four occupational therapists that currently perform as academic at two Chilean universities. During a round table discussion, at the Third Chilean Meeting of Student Occupational Therapy in 2014, and from their own theoretical developments, they meet to take the challenge of explaining why it is so difficult to define what occupational therapy is. Thus, the discussion begins with the pragmatists womens theorist of the early twentieth century and her contributions to understand the processes of health and disease from a holistic perspective as opposed to the dichotomous and reductionist point of view installed by neopositivism science. It continues with Heideggers ontological proposal of Being and Time for explanation of occupation and occupational therapy, assuming an ontological gap in the history of the profession. Then, it presents the contributions from the Actor-Network Theory and how helps to answer the initial question, assuming that the difficulty would be the inability to translate and enroll themselves theoretical developments to other actors. Finally a proposal of epistemological positioning initially developed by Humberto Maturana and Francisco Varela, which derives to the paradigm of complexity, defined by Edgar Morin, is handed in.
Assuntos
Conhecimento , Terapia Ocupacional/históriaRESUMO
Changes in digestive enzyme activity and histology were studied in Atractosteus tropicus embryos, larvae and juvenile periods. Alkaline protease, chymotrypsin, carboxypeptidase A, lipase and α-amylase were detected in all periods and gradually increased until reaching the maximum peak in juveniles; meanwhile, acid protease was first detected at 5 days after hatching (dah) when first feeding started and trypsin and leucine aminopeptidase activities were detected from 19 dah, their values being increased gradually until reaching a maximum value at 31 dah. Acid and alkaline phosphatase activities increased from yolk-sac absorption (3 dah) until day 31 after hatching. Zymogram for acid protease showed two bands in active forms (0.4 and 0.5 Rfs) from day 5 after hatching and a third protease form (0.3 Rf) that appears at 31 dah. Two active forms (26.3 and 24.9 kDa) were detected using SDS-PAGE alkaline proteases zymogram at 5 dah, and an additional active form (44.1 kDa) was detected at 7 dah. Regarding the histological development of the digestive system, the exocrine pancreas containing zymogen granules was already visible at 3 dah, whereas at 5 dah first gastric glands were already detected in the stomach. Between 7 and 9 dah, the digestive tract of A. tropicus resembled that of a juvenile specimen with a well-developed and short oesophagus, stomach divided into a glandular and non-glandular (pyloric) stomach, folded intestine with pyloric caeca and a well-developed spiral valve (posterior intestine). Considering this, larvae of A. tropicus are capable of digesting several foods from yolk absorption (3 dah), maximizing its activities at 15 dah, age at which the organisms maximize its capability to absorb nutrients from diets provided.
Assuntos
Peixes/embriologia , Trato Gastrointestinal/embriologia , Trato Gastrointestinal/metabolismo , Animais , Regulação da Expressão Gênica no Desenvolvimento/fisiologia , Regulação Enzimológica da Expressão Gênica/fisiologia , Larva/metabolismoRESUMO
El presente trabajo se propone navegar en las posibilidades que otorgan las ideas sobre el Ser y el Tiempo desarrolladas por Martin Heidegger, como punto de partida para una reflexión ontológica sobre la ocupación, coherente con el ejercicio de la Terapia Ocupacional. Con este propósito, se revisan y contrastan conceptos centrales de la propuesta del autor alemán con el proyecto ampliamente aceptado por la comunidad de Terapeutas Ocupacionales, la naturaleza ocupacional del ser humano de Ann Wilcock. La discusión, además de centrarse en la invitación a los y las terapeutas ocupacionales a profundizar en este tema, se encuentra con una evidente sincronía entre el dasein hedeggeriano y la ocupación, aspectos que resuenan en la noción de becoming de Wilcock.
The present paper pretends to sail through the posibilities given by the notions about Being and Time developed by Martin Heidegger, as a starting point for an ontological reflection about occupation, coherent with the Occupational Therapy practice. For this purpose, core concepts of the German author are revised and contrasted with the project widely accepted in the occupational therapists community, the occupational nature of the human being by Ann Wilcock. The discussion, in addition to focusing on the invitation to the occupational therapists to go deeper into the topic, encounters an evident synchrony between Heideggers dasein and occupation, both aspects that resonate in Wilcocks notion of becoming.
Assuntos
Humanos , Conhecimento , Terapia Ocupacional , Filosofia , Tempo , Estado de ConsciênciaRESUMO
Medication errors are defined as any preventable event that may cause harm to the patient or lead to inappropriate medication use. There are factors that determine the occurrence of medication errors in health services, such as: insufficient knowledge of patient care load, fast speed in care, variety and complexity of the routes of drug administration, among others. There are multiple studies in Emergency Departments where increased incidence of medication errors where observed. In our Emergency Department the frequency of medication errors was established at 29.4 percent. To avoid these errors, prevention strategies were generated depending on the type of error. As specific strategies in our emergency department we have assured the presence of a clinical pharmacist in the health team, local protocols for indications have been created and ongoing training of health personnel has been mandatory. The objective of these measures is to ensure quality and safety of patient care. We recognize that errors will occur due to the type of care we provide, and therefore we should implement measures at hand to reduce them...
Assuntos
Humanos , Masculino , Feminino , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Sistemas de Comunicação entre Serviços de Emergência , Preparações Farmacêuticas/administração & dosagem , Preparações Farmacêuticas/normas , Serviço Hospitalar de Emergência/normas , Serviço Hospitalar de Emergência/organização & administração , Serviço Hospitalar de EmergênciaRESUMO
Chromosomal abnormalities that result in genomic imbalances are a major cause of congenital and developmental anomalies. Partial duplication of chromosome 3q syndrome is a well-described condition, and the phenotypic manifestations include a characteristic facies, microcephaly, hirsutism, synophrys, broad nasal bridge, congenital heart disease, genitourinary disorders, and mental retardation. Approximately 60%-75% of cases are derived from a balanced translocation. We describe a family with a pure typical partial trisomy 3q syndrome derived from a maternal balanced translocation t(3;13)(q26.2;p11.2). As the chromosomal rearrangement involves the short arm of an acrocentric chromosome, the phenotype corresponds to a pure trisomy 3q26.2-qter syndrome. There are 4 affected individuals and several carriers among three generations. The report of this family is relevant because there are few cases of pure duplication 3q syndrome reported, and the cases described here contribute to define the phenotype associated with the syndrome. Furthermore, we confirmed that the survival until adulthood is possible. This report also identified the presence of glycosaminoglycans in urine in this family, not related to the chromosomal abnormality or the phenotype.
RESUMO
Background: Gastric cancer is one of the leading causes of cancer-related deaths in Chile and worldwide. No consensus exists for therapeutic management. Aim: To assess clinical features and practice patterns of patients with newly diagnosed gastric cancer in Chile. Method: Chilean patients > 18 years old with newly diagnosed primary gastric adenocarcinoma enrolled by thirteen centers from different regions of Chile. Target sample size calculated according to gastric cancer prevalence in Chile. Data collected from two visits within a 10-month timeframe: baseline (patients and tumor features, treatment plan) and end of study (completion of initial treatment). Herein, baseline visit data is presented. Results: Between 2005 and 2008, 523 patients enrolled. Median age 61.3 years. Diagnosis by endoscopy in 98.5 percent patients. Location: body 35.8 percent, proximal 35.4 percent, and antral 23.9 percent. Most frequently used histopathological classification was WHO classification, with tubular adenocarcinoma being most frequent finding (53.1 percent). AJCC/UICC clinical staging (available in 31.1 percent of patients) was: 0 and I - 23.3 percent, II - 18.3 percent, III- 20.8 percent, IV - 37.6 percent. Therapeutic choice based mainly on clinical staging (49.9 percent) and included surgery in 440 patients (84.1 percent). Therapy planned by surgeon (54.9 percent) or multidisciplinary team (42.3 percent). Conclusions: REGATE is the largest prospective multicenter registry study performed in Chile. Basal visit data report that diagnosis is established frequently at advanced stages. Surgery is the most frequent therapeutic choice, (neo-) adjuvant therapies are only planned in one out of four patients. End of study visit data will provide the full scope of diagnosis and treatment of these patients.
Introducción: El cáncer gástrico es una de las principales causas de muerte por cáncer en Chile. No existe consenso acerca del tratamiento. Objetivos: Conocer características clínicas y patrón de tratamiento de pacientes con cáncer gástrico recién diagnosticado. Material y Método: Pacientes chilenos mayores de 18 años con diagnóstico reciente de adenocarcinoma gástrico primario, enrolados en 13 centros de diferentes regiones de Chile. Datos obtenidos en dos visitas dentro de período de 10 meses: basal (características del tumor y paciente, plan de tratamiento) y fin de estudio (tratamiento inicial completado). Se presentan datos de visita basal. Resultados: Entre 2005 y 2008, 523 pacientes enrolados. Mediana edad 61,3 años. Diagnóstico por endoscopia en 98,5 por ciento pacientes. Localización: corporal 35,8 por ciento, proximal 35,4 por ciento y antral 23,9 por ciento. Clasificación histopatológica más usada fue clasificación OMS, y tipo histopatológico más frecuente fue tubular 53,1 por ciento. Etapificación clínica AJCC/UICC (disponible en 37,6 por ciento de pacientes) distribuida en: 0 y I - 23,3 por ciento, II -18,3 por ciento, III - 20,8 por ciento, IV - 37,6 por ciento. Principal característica clínica para elección de terapia planeada fue etapificación clínica (49,9 por ciento). Plan de tratamiento consideró cirugía en 440 pacientes (84,1 por ciento). En mayoría de casos, plan terapéutico decidido por cirujano (54,9 por ciento) o equipo multidisciplinario (42,3 por ciento). Conclusiones: REGATE es el estudio de registro prospectivo multicéntrico más grande desarrollado en Chile. Datos visita basal informan que diagnóstico se establece frecuentemente en etapas avanzadas. Cirugía es alternativa terapéutica más frecuentemente indicada; terapias (neo-) adyuvantes sólo son ofrecidas a uno de cuatro pacientes. Datos visita fin de estudio proveerá visión completa del diagnóstico y tratamiento de estos pacientes.
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Registros de Doenças , Neoplasias Gástricas/epidemiologia , Neoplasias Gástricas/patologia , Neoplasias Gástricas/terapia , Distribuição por Idade , Chile/epidemiologia , Cooperação Internacional , Infecções por Helicobacter/epidemiologia , Estudos Multicêntricos como Assunto , Estadiamento de Neoplasias , Neoplasias Gástricas/classificação , Neoplasias Gástricas/diagnóstico , Estudos Observacionais como Assunto , Avaliação de Processos e Resultados em Cuidados de SaúdeRESUMO
SETTING: Prisons throughout Honduras. OBJECTIVE: To assess the strengths, weaknesses, and opportunities to improve non-standardized tuberculosis (TB) educational campaign materials utilized in prisons. DESIGN: A qualitative assessment was conducted. Prison staff completed a survey describing development and implementation of educational activities at each prison (n=25). Completed surveys with photographs or copies of educational materials were collected and cataloged. The content, literacy demand, illustrations, learning stimulation, and cultural appropriateness of cataloged items were assessed using an adapted version of the Suitability Assessment of Materials Instrument. Results from this assessment were examined in conjunction with information collected through focus groups conducted with prisoners and interviews with prison staff. RESULTS: Campaign strengths included the development and dissemination of print materials appropriate for individuals with low literacy levels. By actively engaging prisoners in the campaigns, materials often incorporated the language, values, and experiences encountered within prison culture. Content of print materials and presentations focused on correcting misperceptions and facilitating acceptance of TB control activities. Campaign weaknesses included the creation of illustrations that could perpetuate the stigma associated with TB and use of some materials in which the purpose was not apparent. CONCLUSIONS: The campaigns were generally suitable, and the evaluation allowed for their improvement.
Assuntos
Educação de Pacientes como Assunto/organização & administração , Prisioneiros/educação , Tuberculose/prevenção & controle , Adulto , Cultura , Feminino , Grupos Focais , Honduras , Humanos , Masculino , Pessoa de Meia-Idade , Educação de Pacientes como Assunto/normas , Avaliação de Programas e Projetos de Saúde , Tuberculose/diagnóstico , Tuberculose/etnologiaRESUMO
Background: Gallbladder cancer is generally associated with a poor prognosis, being local recurrence the main pattern of failure. Aim: To evaluate neoadjuvant chemoradiation as a means to improve the prognosis in gallbladder cancer. Patients and methods: Twenty three gallbladder cancer patients were prospectively treated between June 1993 and September 1999 in the Temuco Regional Hospital. Eighteen (82 percent) patients had subserosal infiltration, while three (13 percent) had serosal and two (9 percent) adipose tissue infiltration. Chemotherapy was done with 5-fluorouracil in continuous infusion during 5 days at day 1 and 28 of treatment. Radiotherapy consisted in a total dose of 4500 cGy, divided in 25 sessions. Patients' survival was compared with a series of 19 patients not subjected to chemoradiation, formerly treated at the institution. Results: Twenty patients had hematological problems secondary to the therapy. Leucopenia and thrombocytopenia were the most common toxic effects and eight had leucopenia under 2.0 x 10 during the treatment course. Chemoradiation delayed surgical treatment in eight patients. After the chemoradiation protocol, seven patients were excluded from surgical treatment and 14 patients underwent resection. Three of the latter (11 percent) had liver involvement and four (14 percent) had lymph node involvement. Among the patients who underwent resection, five are still alive with a follow up of 43.8 months. Treated patients had a worst actuarial survival than subjects not treated with chemoradiation. Conclusions: In this series of patients chemoradiation had no positive effect and a potentially detrimental effect in patients with gallbladder cancer (Rev Méd Chile 2004; 132: 51-7).
Assuntos
Humanos , Adulto , Neoplasias da Vesícula Biliar , Terapia Neoadjuvante , ChileAssuntos
Adaptação Fisiológica , Fígado/efeitos dos fármacos , Fígado/patologia , Oxigenases de Função Mista/farmacologia , Oncorhynchus mykiss/fisiologia , Petróleo/toxicidade , Poluentes Químicos da Água/toxicidade , Animais , Aquicultura , Fígado/enzimologia , Oxigenases de Função Mista/efeitos dos fármacosAssuntos
Hidrocarbonetos/efeitos adversos , Oncorhynchus mykiss/crescimento & desenvolvimento , Poluentes da Água/efeitos adversos , Animais , Relação Dose-Resposta a Droga , Brânquias/patologia , Larva/efeitos dos fármacos , Larva/crescimento & desenvolvimento , Dose Letal Mediana , Fígado/patologia , Petróleo , Pele/patologia , Distribuição TecidualRESUMO
According to cytogenetic analysis, about 50% of Turner individuals are 45,X. The remaining cases have a structurally abnormal X chromosome or are mosaics with a second cell line containing a normal or abnormal sex chromosome. In these mosaics, approximately 20% have a sex marker chromosome whose identity cannot usually be determined by classical cytogenetic methods, requiring the use of molecular techniques. Polymerase chain reaction (PCR), primed in situ labeling (PRINS), and fluorescence in situ hybridization (FISH) analyses were performed in 8 patients with Turner syndrome and 45,X mosaic karyotypes to determine the origin and structure of the marker chromosome in the second cell line. Our data showed that markers were Y-derived in 2 patients and X-derived in the remaining 6 patients. We were also able to determine the breakpoints in the two Y chromosomes. The use of cytogenetic and molecular techniques allowed us to establish unequivocally the origin, X or Y, of the marker chromosomes in the 8 patients with Turner phenotype. This study illustrates the power of resolution and utility of combined cytogenetic and molecular approaches in some clinical cases.
Assuntos
Aberrações dos Cromossomos Sexuais , Síndrome de Turner/genética , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Hibridização in Situ Fluorescente , Mosaicismo/genética , Reação em Cadeia da Polimerase , Marcação in Situ com Primers , Cromossomos em Anel , Cromossomo X/genética , Cromossomo Y/genéticaRESUMO
El cáncer gástrico sigue siendo una de las principales causas de muerte por Ca en Chile y en el mundo, aunque ha aumentado el número de resecciones curativas persiste un alto porcentaje de recidiva y una baja sobrevida global a 5 años. Con el fin de mejorar estos resultados se ha recurrido a diferentes alternativas de terapia adyuvantes, entre ellas la quimiorradioterapia postoperatoria. Se realizaron 12 gastrectomías totales ampliadas y 13 gastrectomías subtotales con linfadenectomías tipo D2 en 23 pacientes y tipo D1 en 2 casos. La anactomía patológica demuestra que el 85,7 por ciento eran Ca avanzados; 7,1 por ciento Ca incipientes submucosos y 7,1 por ciento eran intermedios. El tratamiento QT-RT se realizó después de la 4ª a 6ª semana de la cirugía, durante 5 semanas. Quimioterapia con 5 FU en dosis de 350 mg/m2 en infusión continua la primera y quinta semana, y radioterapia en dosis de 4500 cGy fraccionados durante las mismas 5 semanas, con 2000 cGy en abdomen total y 2500 como sobreimpresión del lecho gástrico y ganglionar. La sobrevida global actuarial para nuestra serie, según Curva de Kaplan-Meir, fue de 63 por ciento a los 12 meses, y de 30 por ciento a los 5 años
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Neoplasias Gástricas/terapia , Protocolos Clínicos , Quimioterapia Combinada , Período Pós-Operatório , Radioterapia , Neoplasias Gástricas/patologiaRESUMO
Gonadal steroid hormones influence vascular tone and the development of hypertension. There are sex differences in the incidence of cardiovascular diseases, and great attention has been placed on the study of estrogen cardiovascular effects. However, there are only a few reports on the effects of testosterone on the vasculature. It is commonly accepted that the mechanism of the action of steroid hormones on target tissues is mediated through the binding of hormones to cytoplasmic or nuclear receptors. However, some studies indicate that steroid action can be extremely rapid and therefore unlikely to be through a genomic mechanism. The purpose of this study was to assess the effect of intravascularly confined testosterone on an isolated rat heart to demonstrate acute and possibly nongenomic effects of the steroid. Our results show that testosterone blocked the adenosine vasodilator effect and increased vascular resistance, even when its presence was restricted to the coronary vascular lumen. These effects were exerted rapidly and possibly through nongenomic mechanisms.
Assuntos
Vasos Coronários/fisiologia , Coração/fisiologia , Testosterona/fisiologia , Adenosina/farmacologia , Animais , Monoterpenos Bicíclicos , Pressão Sanguínea/efeitos dos fármacos , Vasos Coronários/efeitos dos fármacos , Dextranos/química , Coração/efeitos dos fármacos , Técnicas In Vitro , Masculino , Peso Molecular , Óxido Nítrico/antagonistas & inibidores , Perfusão , Antagonistas de Prostaglandina/farmacologia , Ratos , Receptores de Tromboxanos/antagonistas & inibidores , Testosterona/química , Testosterona/farmacologia , Tromboxano A2/análogos & derivados , Tromboxano A2/metabolismo , Tromboxano A2/farmacologia , Fatores de Tempo , Resistência Vascular/efeitos dos fármacos , Resistência Vascular/fisiologia , Vasodilatadores/farmacologiaRESUMO
Histoplasma capsulatum was isolated from gut, lung, liver, and spleen of 17 of 208 captured bats belonging to 6 different genera and species. Three of the 17 infected bats were from the State of Guerrero and 14 were from the State of Morelos. All were adult bats: 6 males (1 Pteronotus parnellii, 2 Natalus stramineus, 2 Artibeus hirsutus, and 1 Leptonycteris nivalis) and 11 females (1 Myotis californicus, 1 Mormoops megalophylla, 8 A. hirsutus, and 1 L. nivalis). High rates of bat infection with H. capsulatum were found in the monitored sites of the State of Morelos. Histoplasma infection of N. stramineus, A. hirsutus, and L. nivalis should be considered as the first records in the world. The fungus isolated from infected bats was identified by its typical mycelial-phase morphology and by its yeast-phase conversion. Exoantigen production confirmed the fungal identification by the presence of specific precipitation lines in double immunodiffusion assays using human immune serum. Histopathologic studies showed intracellular yeast-like cells compatible with H. capsulatum yeast-phase in tissues of several bats, especially in pulmonary (intra-alveolar and septal) macrophages, with none or minimal tissue reaction. In contrast to past reports, present data support a high risk of bat infection with H. capsulatum in Mexican cave environments.