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PURPOSE: The study aimed to analyze the expression of bone morphogenetic protein-2/4 (BMP-2/4) and its receptor BMPR-IA (BMP receptor type IA) in metastatic and nonmetastatic oral squamous cell carcinoma (OSCC) and its implications for disease prognosis. MATERIALS AND METHODS: The experimental group included 16 cases of OSCC without metastasis and 7 cases of OSCC with metastasis. The presence or absence of nodal metastasis was used as a parameter for the evaluation of disease prognosis. Ten cases of oral fibroepithelial hyperplasia were selected as the control group. The expression of BMP-2/4 and BMPR-IA was analyzed by immunohistochemistry. RESULTS: In the experimental group with metastasis, strong expression of BMP-2/4 was observed in most cases (71.4%), whereas BMPR-IA exhibited weak expression (85.7%). In the experimental group without metastasis, there was strong expression of BMP-2/4 (62.5%) and BMPR-IA (100%). A significant association was observed between the prognosis of OSCC and the intensity of BMP-2/4 staining (P = .002). Weak immunoreactivity to BMP-2/4 and BMPR-IA was observed in all control specimens. CONCLUSIONS: The results suggest that strong expression of BMP-2/4, associated with low expression of BMPR-IA, observed in metastatic OSCC has a prognostic value, with the loss of responsiveness to BMPs through the loss of expression of their receptors being indicative of the development of metastasis.

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The aim of the present study was to clinically evaluate the variables pain, swelling and trismus when two different suture techniques were applied in surgery of impacted lower third molars. The sample comprised 20 patients of both genders participating in the clinical trial at the Division of Oral and Maxillofacial Surgery, with an indication for the removal of bilaterally impacted lower third molars. They were divided into test and control groups. Complete suture was performed on the free and attached gums in the control group and only on the attached gum of the oblique vestibular incision in the test group. The results showed that the fact that the drainage of fluid through the suture was not obliterated led to diminution of pain 48 hours after surgery. No statistically significant differences were observed in relation to swelling, which diminished gradually in both groups. As regards the variable trismus, the test group presented a greater mouth opening throughout the evaluation, being statistically significant at 7 days. The probing depth, three months postoperatively, was found to be greater in the control group. This difference reached statistical significance for the vestibular distal region of the adjacent second molar. It is concluded that the strategy of not suturing the free gum of the oblique vestibular incision in the extraction of impacted lower third molars leads to the diminution of immediate painful symptomatology, but has no influence on the swelling.

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Nesta pesquisa buscou-se avaliar a expressão imunoistoquímica dos anticorpos CD105 e FvW na angiogênese do Carcinoma Epidermóide Oral (CEO), correlacionando-o com o estadiamento clínico pelo sistema TNM, visando uma melhor compreensão do seu comportamento biológico e utilização como indicador de prognóstico. A amostra foi composta por 30 casos de CE, sendo 10 de assoalho bucal, 10 da região retromolar e 10 de língua, além de 10 casos de granuloma piogênico, integrantes do grupo controle. Os resultados desta pesquisa mostraram que as médias da MVC foram correspondentemente mais elevadas no grupo do granuloma piogênico (CD105 = 57,26 vasos e FvW = 39,64) do que no grupo do CE (CD105 = 10,09 e FvW = 12,20) e as diferenças se revelaram estatisticamente significantes entre os grupos para cada um dos biomarcadores angiogênicos (p=0,002 para o CD105 e p<0,001 para o FvW ). O CD105 se mostrou com melhor positividade no granuloma piogênico (média = 57,26 vasos) e, para o CE, o FvW foi o que apresentou maior marcação (média = 12,20 vasos). Com relação ao CE, a faixa etária mais acometida foi entre 51 e 70 anos (n=14; 46,7%), apresentando uma MVC representativa para ambos os marcadores. Não se comprovou diferença estatisticamente significante entre os sexos para nenhum dos marcadores (p=0,967 para o CD105 e p=0,744 para o FvW). A média do CD105 foi bem mais elevada entre os pacientes com estadiamento T3 e T4 (17,13) e menos elevada entre os pacientes com estadiamento N+ (6,36). Quando se avaliou o FvW, a média foi mais elevada no grupo dos pacientes com T1 e T2 (12,23), sendo mais baixa nos pacientes com T3 e T4 (12,10), porém sem diferença estatisticamente significante. Em relação à localização anatômica, comprovou-se diferença estatisticamente significante entre as localizações assoalho bucal e retromolar (p=0,013) para o marcador FvW. Portanto, este estudo sugere que a marcação do CD105 na angiogênese do CEO, ao contrário de outros tipos de neoplasias malignas, pode não estar correlacionada com o prognóstico e agressividade do tumor, enquanto que o FvW se mostrou um anticorpo mais efetivo na marcação desta lesão (AU).

The purpose of this study was to assess the immunohistochemical expression of CD105 and FvW antibodies in the angiogenesis of oral epidermoid carcinoma (OEC), correlating it with the TNM clinical staging system, seeking a better understanding of its biological behavior and use as an indicator of prognosis.The sample consisted of 30 epidermoid carcinoma (EC) cases, 10 of the floor of the mouth, 10 of the retromolar region and 10 of the tongue, in addition to 10 cases of pyogenic granuloma, which made up the control group. The results showed that mean microvessel counts (MVC) were correspondingly higher in the pyogenic granuloma group (CD105 = 57.26 vessels and FvW = 39.64) than in the EC group (CD105 = 10.09 and FvW = 12.20) and that the differences were statistically significant between the groups for each of the angiogenic biomarkers (p = 0.002 for CD105 and p< 0.001 for FvW). CD105 had better positivity in the pyogenic granuloma group (mean = 57.26 vessels) and for EC, FvW had the highest expression (mean = 12.20 vessels). With respect to EC, the most affected age group was between 51 and 70 years (n = 14; 46.7%), with a representative MVC for both markers. No statistically significant difference was found between the sexes for any of the markers (p = 0.967 for CD105 and p = 0.744 for FvW). Mean CD105 levels were much higher in patients with stage T3 and T4 (17.13) and lower in those with stage N+ (6.36). Mean FvW levels were higher in the patients with stage T1 and T2 (12.23) and lower in patients with T3 and T4 (12.10), but without a statistically significant difference. In regard to anatomic location, a statistically significant difference was observed between FvW sites, with a statistically significant difference between floor of the mouth cases and those located in the retromolar region (p = 0.013). Therefore, this study suggests that CD105 expression in OEC angiogenesis, in contrast to other types of malignant neoplasias, may not be correlated with prognosis and tumor aggressiveness, whereas FvW was a more effective antibody for staining this lesion (AU).

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OBJECTIVE: The aim of this study was to determine the incidence of glove perforation among undergraduates and residents performing maxillofacial surgery and identify procedures associated with the perforations. STUDY DESIGN: For this purpose, 200 pairs of surgical gloves were used. For inspecting the perforations, the gloves were filled with water, at least 500 ml. RESULTS: Sixteen gloves (8%) were perforated, 8 (4%) by residents and 8 (4%) by undergraduate students. Only the residents noticed that 2 gloves (1%) were perforated and identified the object causing the perforation. The left hand was the more affected with 9 perforations (4.5%). The finger pulp was the region most affected with 12 perforations (6%). The perforated forefinger appeared in 8 gloves (4%), representing the highest incidence of perforations. CONCLUSION: We concluded there was no difference in surgical glove perforation between undergraduate students and residents, the incidence of perforations was greater in the left hand (nondominant hand) and the fingers in which most perforations occurred were the forefinger and the thumb.

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A biópsia de uma lesão bucal é um meio confiável e de fácil execução, que contribui para o diagnóstico definitivo da grande maioria das lesões bucais. Os riscos de realizá-la são mínimos e superam, em muito, as conseqüências de um diagnóstico errôneo e inadequado. Esse artigo visa esclarecer aos Cirurgiões Dentistas e acadêmicos de Odontologia, as indicações, contra-indicações, a técnica e os cuidados para se realizar uma biópsia e, ainda, desmistificá-la, tanto para o profissional que, às vezes, tem receio de executá-la quanto para o paciente que a associa com tumor maligno.

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