RESUMO
Deoxypyridinoline is one of the metabolites produced during bone resorption. Deoxypyridinoline excretion, unlike other markers, is not affected by diet, or the activity level of other tissues. In postmenopausic women, increased excretion of deoxypyridinoline has been associated with increased bone mass loss. The objective of this study was to determine the association of deoxypyridinoline excretion in postmenopausic Mexican women with anthropometric factors, bone mass density, calcium and phosphorous intakes, post menopause years and serum levels of estradiol. The concentration of deoxypyridinoline in 24 h urine was determined utilizing an ELISA technique. An average of 7,27 +/- 5,31 nM Dpd/mM creatinine was found. A negative correlation between deoxypyridinoline and serum estradiol levels (r = -0.37, p = 0.01) was found. Post menopausic years correlated positively (r = .35, p = 0.02) with Dpd. No significant correlation between deoxypyridinoline and anthropometric data, bone mass density, calcium and phosphorous intakes was found. In conclusion, 30% of the subjects of this study had elevated levels of deoxypyridinoline excretion and taking into consideration the negative correlation observed with serum estradiol, this segment of the population could be at risk for accelerated bone loss. Hormone replacement is important for post menopausic women to prevent increased bone loss.
Assuntos
Aminoácidos/urina , Densidade Óssea , Estradiol/sangue , Pós-Menopausa , Absorciometria de Fóton , Fatores Etários , Biomarcadores/sangue , Biomarcadores/urina , Cálcio da Dieta/análise , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , México , Pessoa de Meia-Idade , Fósforo na Dieta/análise , Pós-Menopausa/sangue , Pós-Menopausa/fisiologia , Pós-Menopausa/urinaRESUMO
Ascorbic acid is one of the important antioxidant nutrients that can aid in the prevention of oxidative cellular damage. Adequate dietary intake is essential as humans can not synthesize this vitamin. It has been reported that smokers require higher dietary intakes to maintain their serum levels. The objective of this study was to determine serum levels of ascorbic acid in young male smokers and non smokers in the city of Hermosillo, Sonora, Mexico. In addition, their dietary intake of ascorbic acid was determined by a 24 h dietary recall. The dietary intake of ascorbic acid in 12 smokers was 64 +/- 11 mg/d and in 13 non smokers it was 70 +/- 12 mg/d. The smokers in this study did not meet the dietary recommendation of 100 mg/d. Serum ascorbic acid values in smokers and non smokers were 24.2 +/- 6.9 mumol/L and 30.9 +/- 3.7 mumol/L respectively. No significant difference was found among the 2 groups. Although the average serum ascorbic acid values fell within the range considered normal, 50% of the smokers had individual values that were below 23 mumol/L, indicating that these subjects have hipovitaminosis. A positive correlation between intake and serum levels was obtained for smokers (r = 0.71; p = 0.03). The results of this study suggest smokers may be at increased risk for chronic diseases due to their low intake and low serum levels of ascorbic acid.
Assuntos
Antioxidantes/administração & dosagem , Antioxidantes/análise , Ácido Ascórbico/administração & dosagem , Ácido Ascórbico/sangue , Dieta , Fumar/sangue , Adolescente , Adulto , Comportamento Alimentar , Humanos , Masculino , México , Pessoa de Meia-Idade , Fumar/efeitos adversosRESUMO
Diet is responsible for about one third of the cancers. Dietary fiber, energy intake, fat and consumption of fruits and vegetables play an important role in different cancers. The regional Mexican diet is characterized as being high in dietary fiber, high in fat and energy but very low in fruits and vegetables. The diet is high in insoluble fiber and phytate. The objective of this study was to evaluate the composition of the regional diet and relate this composition to the incidence of colon cancer in the northern region of México. Two traditional diets, one higher in fruits and vegetables, but both high in fat and dietary fiber were evaluated. A mathematical expression showed the typical regional diet to be low antioxidant nutrients, even though an earlier study showed it to have a tendency to protect against colon cancer. During the years of 1991-1995, Sonora, México reported about 20 cases/ 100,000 inhabitants of colon cancer. This incidence is low compared to other regions and high dietary fiber is thought to be responsible. If antioxidant nutrient intake was elevated, possibly a greater protection could be achieved.