Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
Braz J Phys Ther ; 19(5): 421-8, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26537812

RESUMO

BACKGROUND: Injuries to runners are common. However, there are many potential contributing factors to injury. While lack of flexibility alone is commonly related to injury, there are clear differences in hamstring flexibility between males and females. OBJECTIVE: To compare the effect of static hamstring length on sagittal plane mechanics between male and female runners. METHOD: Forty subjects (30.0±6.4 years) participated and were placed in one of 4 groups: flexible males (n=10), inflexible males (n=10), flexible females (n=10), and inflexible females (n=10). All subjects were free of injury at the time of data collection. Three-dimensional kinematics and kinetics were collected while subjects ran over ground across 2 force platforms. Sagittal plane joint angles and moments were calculated at the knee and hip and compared with a 2-way (sex X flexibility) ANOVA (α=0.05). RESULTS: Males exhibited greater peak knee extension moment than females (M=2.80±0.47, F=2.48±0.52 Nm/kg*m, p=0.05) and inflexible runners exhibited greater peak knee extension moment than flexible runners (In=2.83±0.56, Fl=2.44±0.51 Nm/kg*m, p=0.01). For hip flexion at initial contact, a significant interaction existed (p<0.05). Flexible females (36.7±7.4º) exhibited more hip flexion than inflexible females (27.9±4.6º, p<0.01) and flexible males (30.1±9.5º, p<0.05). No differences existed for knee angle at initial contact, peak knee angle, peak hip angle, or peak hip moment. CONCLUSION: Hamstring flexibility results in different mechanical profiles in males and females. Flexibility in the hamstrings may result in decreased moments via active or passive tension. These differences may have implications for performance and injury in flexible female runners.


Assuntos
Músculos Isquiossurais/fisiologia , Articulação do Joelho/fisiopatologia , Amplitude de Movimento Articular/fisiologia , Corrida , Adulto , Feminino , Humanos , Masculino , Corrida/fisiologia
2.
Biochim Biophys Acta ; 1139(1-2): 105-14, 1992 Jun 09.
Artigo em Inglês | MEDLINE | ID: mdl-1610910

RESUMO

A system consisting of isolated rat hepatocytes immobilized in agarose threads continuously perifused with oxygenated Krebs-Henseleit (KH) solution has been found to maintain cell viability with excellent metabolic activity for more than 6 h. The hepatocytes were monitored by phosphorus-31 nuclear magnetic resonance (31P-NMR) spectroscopy at 4.7 Tesla, by measurement of oxygen consumption and by the leakage of lactate dehydrogenase (LD) and alanine aminotransferase (ALT). The data obtained were comparable to those found for an isolated perfused whole liver in vitro. The effects of allyl alcohol (AA), ethanol, and 4-acetaminophenol (AP) were examined. A solution of 225 microM AA perifused for 90 min caused the disappearance of the beta-phosphate resonance of adenosine triphosphate (ATP) in the 31P-NMR spectra, a 7-fold increase in LD leakage and a 70% reduction in oxygen consumption. Ethanol (1.0 M) perifused for 90 min reduced the beta-ATP signal intensity ratio by 20%, the phosphomonoester (PME) signal by 50% and inorganic phosphate (Pi) by 33% (P less than 0.05). AP (10 mM) caused only mild liver-cell damage. The results demonstrate that perifused immobilized hepatocytes can be used as a liver model to assess the effects of a wide range of chemicals and other xenobiotics by NMR spectroscopy.


Assuntos
Fígado/efeitos dos fármacos , Animais , Sobrevivência Celular/efeitos dos fármacos , Citosol/enzimologia , Metabolismo Energético/efeitos dos fármacos , Etanol/farmacologia , Técnicas In Vitro , L-Lactato Desidrogenase/análise , Fígado/enzimologia , Fígado/metabolismo , Espectroscopia de Ressonância Magnética , Masculino , Consumo de Oxigênio/efeitos dos fármacos , Perfusão , Ratos , Ratos Endogâmicos , Sefarose
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA