RESUMO
The Fc-receptor function of the mononuclear phagocyte system (MPS) was examined in 41 children and adult patients, by measuring the clearance of IgG-sensitized, 51Cr-labeled erythrocytes. The Fc-receptor-mediated clearance observed in patients (mean +/- SE) was not significantly different as compared to the control group of similar age distribution. However, the immune clearance time was significantly age-correlated in both groups (acute poststreptococcal glomerulonephritis, APSGN, r = 0.39, p less than 0.05; control r = 0.63, p less than 0.01). The magnitude of the Fc-specific immune clearance and the serum creatinine were also significantly correlated (r = 0.59; p less than 0.01). Circulating immune complexes (as measured by the C1q and conglutinin ELISA) did not correlate with immune clearance, which remained stable in longitudinal studies. Age-related changes in MPS Fc-receptor function could explain, at least in part, prognostic differences between children and adult patients with APSGN.
Assuntos
Envelhecimento/fisiologia , Glomerulonefrite/fisiopatologia , Fagócitos/ultraestrutura , Receptores Fc/fisiologia , Infecções Estreptocócicas/fisiopatologia , Adolescente , Adulto , Idoso , Criança , Radioisótopos de Cromo , Creatina/sangue , Ensaio de Imunoadsorção Enzimática , Eritrócitos/metabolismo , Eritrócitos/fisiologia , Feminino , Glomerulonefrite/etiologia , Glomerulonefrite/microbiologia , Histocompatibilidade , Humanos , Masculino , Taxa de Depuração Metabólica/fisiologia , Pessoa de Meia-Idade , Fagócitos/fisiologia , Baço/patologia , Baço/fisiologia , Baço/ultraestrutura , Infecções Estreptocócicas/complicaçõesAssuntos
Saúde Pública , Sociedades , Chile , Governo , Planejamento em Saúde , Mão de Obra em Saúde , Direitos Humanos , Política , Estados UnidosRESUMO
Developing a balanced approach to today's health problems means paying greater attention to the strategy of prevention. This strategy should encompass environmental measures, self-care activities, and health education; it should carefully weigh the prospective costs and benefits of proposed preventive measures; and it should see that such measures are tailored to the needs of the various specific groups within the general population.
Assuntos
Medicina Preventiva , Criança , China , Cuba , Atenção à Saúde , Saúde Ambiental , Feminino , Educação em Saúde , Humanos , Serviços de Saúde Materna , México , Serviços de Saúde do Trabalhador , Exame Físico , Gravidez , Serviços Preventivos de Saúde , Atenção Primária à Saúde , Saúde Pública , Serviços de Saúde Escolar , Estados UnidosRESUMO
Developing a balanced approach to today's health problems means paying greater attention to the strategy of prevention. This strategy should encompass environmental measures, self-care activities, and health education; it should carefully weigh the prospective costs and benefits of proposed preventive measures; and it should see that such measures are tailored to the needs of the various specific groups within the general population (Au)