RESUMO
Plasmodium brasilianum causes chronic quartan malaria in the common marmoset Callithrix jacchus, whereas Epstein-Barr virus (EBV) infection is followed by an infectious mononucleosis-like syndrome that resolves. We infected weanling marmosets with one or both of these pathogens. Timing of the infections influenced outcome. Six animals were simultaneously infected with both agents; four became seriously ill (with accompanying proteinuria and edema) and either died or were killed. Histopathology indicated that glomerulonephritis had developed. The two survivors had more-prolonged parasitemia than did animals infected with P. brasilianum alone, as did animals infected with EBV before P. brasilianum. Five of the six simultaneously infected animals had absent or low titers of antibody to Epstein-Barr viral capsid antigens when compared with the other EBV-infected animals. Our results suggest that combined infection may be part of the etiology of quartan malarial nephropathy.
Assuntos
Proteínas do Capsídeo , Glomerulonefrite/etiologia , Infecções por Herpesviridae/complicações , Malária/complicações , Animais , Anticorpos Antiprotozoários/biossíntese , Anticorpos Antivirais/biossíntese , Antígenos Virais/imunologia , Callithrix , Modelos Animais de Doenças , Glomerulonefrite/patologia , Infecções por Herpesviridae/patologia , Herpesvirus Humano 4/imunologia , Rim/patologia , Fígado/patologia , Malária/patologia , Plasmodium/imunologia , Baço/patologiaRESUMO
Chronic quartan malarial infection has been established in the common marmoset (Callithrix jacchus). Plasmodium brasilianum from a douroucouli monkey (Aotus trivirgatus) was used to infect splenectomized twin animals, passed to an intact animal, and then to 4 other intact adults, 2 pairs of twins. In 2 of the 4 latter animals there was continuing patency with parasitaemias of less than or equal to 0.5% parasitized erythrocytes for 30 weeks. The other 2 had lower initial levels of parasitaemia; in 1 of these parasitaemias remained low or subpatent. All marmosets developed lymphocytosis. One animal became ill 30 weeks after infection with anaemia, weight loss and mild proteinurea, the other 3 remained well. Histological examination showed minor changes in the kidneys; spleens of infected animals showed marked follicular hyperplasia and phagocytosis of pigment. The livers showed sinusoidal hypercellularity and pigment deposition and in splenectomized animals, a marked lymphoid follicular hyperplasia in the portal tracts.
Assuntos
Callithrix/parasitologia , Callitrichinae/parasitologia , Modelos Animais de Doenças , Malária/parasitologia , Plasmodium/fisiologia , Animais , Aotus trivirgatus/sangue , Aotus trivirgatus/parasitologia , Feminino , Interações Hospedeiro-Parasita , Hiperplasia , Hepatopatias Parasitárias/patologia , Linfocitose , Malária/patologia , Masculino , Fagocitose , Baço/parasitologia , Baço/patologia , EsplenectomiaRESUMO
Estudou-se o efeito da infeccao causada por especie letal (Plasmodium berghei) e nao-letal (P. yoelii) de plasmodio sobre o sistema de fagocitos mononucleares de camundongo BALB/c. OP. yoelii causou maior e mais prolongada expansao e ativacao do sistema de macrofagos. As duas mais importantes populacoes de fagocitos esplenicosmacrofagos de polpa vermelha e da zona marginal - exibiam maior aumento do numero de celulas nesta infeccao. Durante a evolucao da malaria por P. berghei, o baco foi progressivamente ocupado por tecido hematopoietico e, na fase terminal da infeccao, observou-se significativa deplecao dos linfocitos e macrofagos esplenicos. Os dados apresentados indicam que a evolucao da malaria depende do tipo de interacao entre o plasmodio e o sistema de fagocitos mononucleares