RESUMO
The Cuban Human Brain Mapping Project (CHBMP) repository is an open multimodal neuroimaging and cognitive dataset from 282 young and middle age healthy participants (31.9 ± 9.3 years, age range 18-68 years). This dataset was acquired from 2004 to 2008 as a subset of a larger stratified random sample of 2,019 participants from La Lisa municipality in La Habana, Cuba. The exclusion criteria included the presence of disease or brain dysfunctions. Participant data that is being shared comprises i) high-density (64-120 channels) resting-state electroencephalograms (EEG), ii) magnetic resonance images (MRI), iii) psychological tests (MMSE, WAIS-III, computerized go-no go reaction time), as well as iv,) demographic information (age, gender, education, ethnicity, handedness, and weight). The EEG data contains recordings with at least 30 minutes in duration including the following conditions: eyes closed, eyes open, hyperventilation, and subsequent recovery. The MRI consists of anatomical T1 as well as diffusion-weighted (DWI) images acquired on a 1.5 Tesla system. The dataset presented here is hosted by Synapse.org and available at https://chbmp-open.loris.ca .
Assuntos
Mapeamento Encefálico , Cognição , Eletroencefalografia , Imageamento por Ressonância Magnética , Adolescente , Adulto , Idoso , Cuba , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Adulto JovemRESUMO
There are few studies on the neuroanatomical determinants of EEG spectral properties that would explain its substantial inter-individual variability in spite of decades of biophysical modeling that predicts this type of relationship. An exception is the negative relation between head size and the spectral position of the alpha peak (P(alpha)) reported in Nunez et al. (1978)-proposed as evidence of the influence of global boundary conditions on slightly damped neocortical waves. Here, we attempt to reexamine this finding by computing the correlations of occipital P(alpha) with various measures of head size and cortical surface area, for 222 subjects from the EEG/MRI database of the Cuban Human Brain Mapping Project. No relation is found (p>0.05). On the other hand, biophysical models also predict that white matter architecture, determining time delays and connectivities, could have an important influence on P(alpha). This led us to explore relations between P(alpha) and DTI fractional anisotropy by means of a multivariate penalized regression. Clusters of voxels with highly significant relations were found. These were positive within the Posterior and Superior Corona Radiata for both hemispheres, supporting biophysical theories predicting that the period of cortico-thalamocortical cycles might be modulating the alpha frequency. Posterior commissural fibers of the Corpus Callosum present the strongest relationships, negative in the inferior part (Splenium), connecting the inferior occipital lobes and positive in the superior part (Isthmus and Tapetum), connecting the superior occipital cortices. We found that white matter architecture rather than neocortical area determines the dynamics of the alpha rhythm.
Assuntos
Ritmo alfa , Mapeamento Encefálico , Encéfalo/anatomia & histologia , Encéfalo/fisiologia , Imageamento por Ressonância Magnética , Humanos , Interpretação de Imagem Assistida por Computador , Processamento de Sinais Assistido por ComputadorRESUMO
Se registró el electroencefalograma (EEG) de 10 sujetos normales (25 a 35 años de edad) para obtener las medidas espectrales de banda anch (MEBAs). En cada uno de los sujetos y en sesiones diferentes se recigió el EEG después de la ingestiòn de decocciones al 2 y al 6% de Justicia pectoralis y un placebo. Los resultados muestran que en la comparación, mediante la "T apareada", de las decocciones de Justicia pectoralis con el placebo aparecen diferencias estadisticamente significativas. Estos resultados sugieren la presencia de Justicia pectoralis de principios activos de acciòn neutrópica