RESUMO
Bacterial communities in the mammalian reproductive system can be rich and diverse, differing in structure and quantity depending on location. In addition, its microbiome is associated with the state of health of this tract and reproductive success. This study evaluated the microbiome composition of the uterine body (UB) and uterine horn mucosa (UH) samples using 16S rRNA sequencing of samples extracted from cows in the Amazon region. It was observed that four main phyla were shared between the uterine sites: Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria. Linear discriminant analysis effect size and heat tree analysis showed that members of Lachnospiraceae (NK3A20 group) and Oscillospiraceae were significantly more abundant in the UB than in UH. In addition, there are more unique genera in the UB than in the UH. A higher bacterial load in UB than in UH is expected because of the exposure to external factors of UB. However, comparing the site's communities through beta diversity did not generate well-defined clustering. Thus, it can be attributed to the closeness of the sites, which would make the niches similar ecologically and microbiologically. Therefore, this research provides knowledge to understand biomarkers in the prior reproduction period.
Assuntos
Microbiota , Feminino , Animais , Bovinos , RNA Ribossômico 16S/genética , RNA Ribossômico 16S/análise , Microbiota/genética , Útero/microbiologia , Bactérias/genética , Firmicutes/genética , Mamíferos/genéticaRESUMO
Sezary syndrome (SS) and mycosis fungoides (MF) are a group of non Hodgkin lymphomas that originate from T-lymphocytes and involve mostly the skin. These entities are generally non treatable and patient prognosis remains poor even with the advent of current treatment schedules. Complete remissions are seldom observed. For this reason, bone marrow transplant has been used as a treatment option. The high mortality associated with this procedure has turned reduced intensity conditioning stem cell transplant into a treatment option. This case study illustrates how stem cell transplant offers complete remission of this type of lymphomas.
Assuntos
Transplante de Células-Tronco Hematopoéticas , Micose Fungoide/cirurgia , Neoplasias Cutâneas/cirurgia , Adulto , Feminino , Humanos , Indução de RemissãoRESUMO
La micosis fungoides y el síndrome de Sezary están constituidos por un grupo de linfomas no Hodgkin indolentes, extranodales, con origen en linfocitos T; afectan la piel de manera primaria; son generalmente incurables y los pacientes tienen mal pronóstico porque la enfermedad es habitualmente refractaria a diversas modalidades terapéuticas. El trasplante de médula ósea alogénico es una opción terapéutica más. La alta mortalidad del acondicionamiento pretrasplante convencional ha hecho que se considere el trasplante alogénico con acondicionamiento de intensidad reducida como una opción viable para esta enfermedad. Se presenta el caso de una paciente con micosis fungoides a quien se hizo un trasplante hematopoyético con un esquema no mieloablativo y en quien se logró remisión completa sostenida de la enfermedad.
Sezary syndrome (SS) and mycosis fungoides (MF) are a group of non Hodgkin lymphomas that originate from T-lymphocytes and involve mostly the skin. These entities are generally non treatable and patient prognosis remains poor even with the advent of current treatment schedules. Complete remissions are seldom observed. For this reason, bone marrow transplant has been used as a treatment option. The high mortality associated with this procedure has turned reduced intensity conditioning stem cell transplant into a treatment option. This case study illustrates how stem cell transplant offers complete remission of this type of lymphomas.
Assuntos
Humanos , Feminino , Adulto , Transplante de Células-Tronco Hematopoéticas , Micose Fungoide/cirurgia , Neoplasias Cutâneas/cirurgia , Indução de RemissãoRESUMO
Introducción. La histiocitosis de células de Langerhans (HCL) es una alteración inmunológica que consiste en la proliferación e infiltración de histiocitosis, puede ser sistémica o localizada. El diagnóstico es histopatológico y el tratamiento es con quimioterapia, radioterapia y/o cirugía, dependiendo de la localización. No se ha descrito a la fecha compromiso gonadal. Caso Clínico. Masculino de 6 años con padecimiento de 24 horas de evolución con aumeto de volumen escrotal derecho, súbito, indoloro, hiperemia local y transiluminación negativa. El ultrasonido y la tomografía axial computada mostraron líquido intraescrotal escapsulado y crecimiento testicular derecho. En la exploración quirúrgica se encontró hidrocele hemorrágico con engrosamiento de la túnica vaginal y un nódulo en el cordón espermático que fueron resecados además de biopsia testicular. El estudio histopatológico reveló HCL en la vaginal y en el nódulo, sin afectación testicular. Los estudios de extensión fueron negativos. Conclusiones. Primer caso de HCL en la túnica vaginal testicular. El tratamiento curativo es la resección de la lesión en la forma localizada. Puede ser causa de hidrocele a tensión