RESUMO
Aspirin sensitivity occurs in 10% of all asthmatics patients. In this subset of asthmatics, nasal congestion and bronchospasm occurs between 30-180 minutes after ingestion of aspirin. Following a respiratory reaction to aspirin, all patients can be desensitized to aspirin by repetitively introducing small and then larger doses of aspirin until the asthmatic subject can ingest 650 mg of aspirin without adverse effect. The mechanism of aspirin sensitivity are incompletely understood. And the reasons why ASA desensitization occurs universally are unknown. In this study, known ASA sensitive and control insensitive asthmatics were challenged with ASA. Urine was collected before, during induced bronchospasm, and after ingestion of 650 mg of ASA when the adverse effect (ie., acute desensitization) had subsided. Excretion levels of cyclo-oxygenase and lipoxygenase products in the urine were determined.
Assuntos
Ácido Araquidônico/metabolismo , Aspirina/efeitos adversos , Asma/induzido quimicamente , Dessensibilização Imunológica , Hipersensibilidade a Drogas/etiologia , Leucotrieno E4/urina , Tromboxano B2/urina , Acetaminofen/efeitos adversos , Adulto , Idoso , Aspirina/farmacologia , Aspirina/uso terapêutico , Asma/terapia , Asma/urina , Biotransformação , Espasmo Brônquico/induzido quimicamente , Espasmo Brônquico/urina , Creatinina/sangue , Reações Cruzadas , Inibidores de Ciclo-Oxigenase/farmacologia , Hipersensibilidade a Drogas/terapia , Hipersensibilidade a Drogas/urina , Feminino , Humanos , Hidrocortisona/efeitos adversos , Leucotrienos/biossíntese , Lipoxigenase/metabolismo , Masculino , Pessoa de Meia-Idade , Modelos Imunológicos , Prostaglandina-Endoperóxido Sintases/metabolismo , Sulfitos/efeitos adversosRESUMO
Although the mechanism of aspirin-induced asthma is unknown, it has be suggested that adverse nasal and bronchial reactions are caused by an increased production of lipoxygenase products. We have measured the release of urinary LTE4, TXB2 and 11-dehydro-TXB2 of aspirin induced asthmatics and controls by radioimmunoassay and HPLC methods during aspirin challenge and after desensitization. The overproduction demonstration of urinary LTE4 during aspirin challenge and the decrease after desensitization in inversal direct proportion manner with TXB2 suggest a "shunting" of the arachidonic acid metabolites of the target cells. Whichever theory is to be pursued further, it must also accommodate the clinical effect of aspirin densitization.
Assuntos
Aspirina/efeitos adversos , Asma/induzido quimicamente , Ácido Araquidônico/metabolismo , Humanos , Leucotrienos/metabolismoRESUMO
Although the mechanism of aspirin-induced asthma is unknown, it has been suggested that adverse nasal and bronchial reactions are caused by an increased production of lipoxigenase products. In examining the hypothesis of inhibition on cycloxigenase, we support evidence in favor of this theory. We have measure the release of urinary LTE4, TXB2 and 11-dehydro-TXB2 of aspirin-induced asthmatics and controls by radioimmunoassay and HPLC methods during aspirin challenge and after desensitization. The over production demonstration of urinary LTE4 during aspirin challenge and the decrease after desensitization in inversal direct proportion manner with TXB2 suggest a "shunting" of the arachidonic acid metabolites of the target cells. Whichever theory is to be pursed further, it must also accommodate the clinical effect of aspirin desensitization.
Assuntos
Ácido Araquidônico/metabolismo , Aspirina/efeitos adversos , Asma/induzido quimicamente , Humanos , Leucotrienos/metabolismo , Prostaglandina-Endoperóxido Sintases/metabolismo , Tromboxanos/metabolismoRESUMO
Acetylsalicylic acid is one of the most commonly used drugs and high on the list of causes of drug reactions. Since early publication on 1902 by Hirschberg, a great deal of information has emerged on aspirin sensitivity, including data on epidemiology, further characterization of the two major subtypes of sensitivity (bronchospastic and urticarial types), hereditary aspects, cross-reactions to other nonsteroidal antiinflammatory drugs, and methods of desensitization. Although the pathogenesis of aspirin-sensitive asthma remains unknown, several theories has been proposed to explain the disease enigma.
Assuntos
Ácido Araquidônico/metabolismo , Aspirina/efeitos adversos , Asma/induzido quimicamente , Anti-Inflamatórios não Esteroides/efeitos adversos , Aspirina/farmacologia , Asma/diagnóstico , Asma/imunologia , Asma/metabolismo , Asma/terapia , Dessensibilização Imunológica , Predisposição Genética para Doença , Inflamação/fisiopatologia , Modelos Biológicos , Viroses/complicaçõesRESUMO
Acetylsalicylic acid, one of the most commonly used drugs and high on the list of causes of drug reactions. Since early publication on 1902 by Hirschberg, a great deal of information has emerged on aspirin sensitivity, including data on epidemiology, further characterization of the two major subtypes of sensitivity (bronchospastic and urticarial types), hereditary aspects, cross-reactions to other nonsteroidal antiinflammatory drugs, and methods of desensitization. Although the pathogenesis of aspirin-sensitive asthma remains unknown, several theories has been proposed to explain the disease enigma.
Assuntos
Ácido Araquidônico/efeitos adversos , Ácido Araquidônico/metabolismo , Aspirina/efeitos adversos , Asma/induzido quimicamente , HumanosRESUMO
This report includes a partial interpretation of the possible mechanisms of action related with the efficacy of specific immunotherapy with allergens. This cannot be explained by only one mechanism which regulates the immune reaction, which is why there is the relief that there is a large field in immunology which has yet to be explore.
Assuntos
Dessensibilização Imunológica , Hipersensibilidade/terapia , Alérgenos/administração & dosagem , Alérgenos/imunologia , Alérgenos/uso terapêutico , Animais , Humanos , Hipersensibilidade/imunologia , Camundongos , Modelos ImunológicosRESUMO
The therapeutic panorama of immunomodulation and its effects on the modification of the immune reaction is reviewed. Particular reference is made to the transfer factor as a therapeutic element in bronchial asthma, which insures its efficacy or innocuity.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Asma/terapia , Fator de Transferência/uso terapêutico , Citotoxicidade Celular Dependente de Anticorpos/efeitos dos fármacos , Asma/imunologia , Antígenos CD11/biossíntese , Antígenos CD11/genética , Humanos , Imunidade Celular/efeitos dos fármacos , Células Matadoras Naturais/efeitos dos fármacos , Fator de Transferência/farmacologiaRESUMO
The climatic conditions and the vegetation in the valley of Mexico are analyzed in virtue of their modification during the last few years which have consequently altered the surrounding ecological systems. In this article, we were particularly interested in describing the botanical characteristics of the gimnospermas, an abundant vegetation in Mexico.
Assuntos
Pólen , Árvores , Geografia , MéxicoRESUMO
This research reports the unique case of manifestation of symptomatic dermographism which includes all of its twenty five members of the family. Probing a genetic transmission autosomal dominant manner and taking into account the highly probable role of HLA in this illness. The symptomatic dermographism correspond to a group of physical familiar urticarias with symptoms appearing in early childhood and evolving throughout adulthood with seldom periods of remission. Due to the fact that all patients were affected, it was not possible to realize a typification of HLA antigens with persons not affected, to establish a relationship with the data obtained. However, results show a significant association of haplotypes; HLA A2 (78.95), B16 (68.4%), A1 (47.3%), and B5 (42.5%) among the most important. This is the first research that reports the analysis of HLA within the physical familial urticarias.