RESUMO

BACKGROUND: UV radiation is a risk factor for nonmelanoma skin cancer (NMSC). The relation between DNA damage and oncogenesis suggests that diminished DNA repair capacity (DRC) is involved in tumorigenesis. OBJECTIVE: The purpose of this study was to test the hypothesis that a low DRC is a susceptibility factor for the development of NMSC in Puerto Rico. METHODS: A case-control retrospective clinical study was done to compare the age-adjusted DRC in participants with and without NMSC. DRC was measured using a host cell reactivation assay with a luciferase reporter gene irradiated with UV light and transfected into human peripheral lymphocytes. An epidemiologic questionnaire was used to solicit risk factors. RESULTS: The mean (+/-2 SE) DRC of 177 control patients without skin cancer was 8.6% +/- 0.7. Participants (280) with NMSC had a 42% lower DRC (5.0% +/- 0.3). CONCLUSION: A low DRC is a susceptibility factor for NMSC.

Assuntos

Dano ao DNA/genética , Reparo do DNA/genética , Neoplasias Cutâneas/etnologia , Neoplasias Cutâneas/genética , População Branca/genética , Adulto , Distribuição por Idade , Idoso , Carcinoma Basocelular/etnologia , Carcinoma Basocelular/genética , Carcinoma de Células Escamosas/etnologia , Carcinoma de Células Escamosas/genética , Estudos de Casos e Controles , Feminino , Predisposição Genética para Doença , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/etnologia , Neoplasias Primárias Múltiplas/genética , Razão de Chances , Porto Rico/epidemiologia , Estudos Retrospectivos , Medição de Risco , Distribuição por Sexo