RESUMO

The prevalence of mutations that confer resistance to antiretroviral drugs was examined in 56 drug-naive, human immunodeficiency virus type 1 (HIV-1)-infected individuals from the Army Health Service in Rio de Janeiro, Brazil. No primary protease inhibitor mutations were found, but secondary mutations were observed in 51.2% of the samples. Fourteen percent of the viruses had reverse transcriptase inhibitor-associated mutations. Comparative analysis of protease secondary mutations from four different time periods in drug-naive patients in the city of Rio de Janeiro has indicated constant rates for particular mutations. Changes in CD4 cell counts and HIV viral load over time in subtype B- and non-B-infected drug-naive patients were not significantly different.

Assuntos

Síndrome da Imunodeficiência Adquirida/tratamento farmacológico , HIV-1/efeitos dos fármacos , Mutação , Adulto , Sequência de Bases , Farmacorresistência Viral , Feminino , Proteína gp41 do Envelope de HIV/genética , Protease de HIV/genética , Transcriptase Reversa do HIV/genética , HIV-1/classificação , Humanos , Masculino , Militares , Dados de Sequência Molecular