RESUMO

Adipocytokines are substances produced by adipocytes responsible for the regulation of several physiological processes. Among those substances, leptin and adiponectin have been intensively investigated because of their possible effects on metabolism, reproduction, hematopoiesis and cardiovascular system. The current study aimed to assess the effects of adipocytokines, leptin and adiponectin on cardiac and respiratory functions, as well as on the hematological parameters of healthy female dogs of different breeds. Parameters of rectal temperature, diastolic blood pressure, systolic blood pressure, mean arterial pressure, pulse, heart rate and respiratory rate were evaluated in fifty two healthy female dogs. Blood samples were collected for complete blood count and plasma leptin and adiponectin measurement via ELISA technique. There was no difference in circulating levels of adipocytokines among the different breeds (p 0,05). Negative correlation between leptin and mean corpuscular hemoglobin concentration was found, while it was positive regarding systolic blood pressure, heart rate and breathing. Adiponectin was positively correlated with red blood cells and platelets and negatively with heart rate, respiratory rate, diastolic blood pressure and pulse. Adipocytokines, leptin and adiponectin, exert regulatory effects on cardiorespiratory function and hematopoiesis in healthy f

RESUMO

Adipocytokines are substances produced by adipocytes responsible for the regulation of several physiological processes. Among those substances, leptin and adiponectin have been intensively investigated because of their possible effects on metabolism, reproduction, hematopoiesis and cardiovascular system. The current study aimed to assess the effects of adipocytokines, leptin and adiponectin on cardiac and respiratory functions, as well as on the hematological parameters of healthy female dogs of different breeds. Parameters of rectal temperature, diastolic blood pressure, systolic blood pressure, mean arterial pressure, pulse, heart rate and respiratory rate were evaluated in fifty two healthy female dogs. Blood samples were collected for complete blood count and plasma leptin and adiponectin measurement via ELISA technique. There was no difference in circulating levels of adipocytokines among the different breeds (p 0,05). Negative correlation between leptin and mean corpuscular hemoglobin concentration was found, while it was positive regarding systolic blood pressure, heart rate and breathing. Adiponectin was positively correlated with red blood cells and platelets and negatively with heart rate, respiratory rate, diastolic blood pressure and pulse. Adipocytokines, leptin and adiponectin, exert regulatory effects on cardiorespiratory function and hematopoiesis in healthy f

RESUMO

Background: Canine hemangiosarcoma is a malignant neoplasm of endothelial cells. Such tumor has most commonly its primary location in the spleen, right atrium, subcutaneous tissue and liver. In general, metastases occur in the liver, omentum, mesentery and lung. The nervous system may be a metastasis site, but with rare spinal cord involvement. This paper aims at the description of canine cutaneous hemangiosarcoma with metastasis to the central nervous system.Case: A dog presented history of skin neoplasia. The patient underwent physical examination, which detected an exophytic tumor in the foreskin. Needle aspiration of the lesion was carried out, suggesting the presence of malignant neoplasm of mesenchymal origin. So, the lesion surgical excision was the option. Before the procedure, complementary preoperative examinations of the patient were required. Those corresponded to chest radiographs, abdominal ultrasound, complete blood count, serum urea, creatinine, alanine aminotransferase, aspartate aminotransferase and total protein. The image diagnostic of the thoracic and abdominal cavities showed no noteworthy changes. The hematology and serum biochemistry were normal. The tumor obtained during surgery was sent for histopathological analysis, whose diagnosis corresponded to hemangiosarcoma. Chemotherapy treatment was not possible in the animal. Nine months after the surgery, a

Background: Canine hemangiosarcoma is a malignant neoplasm of endothelial cells. Such tumor has most commonly its primary location in the spleen, right atrium, subcutaneous tissue and liver. In general, metastases occur in the liver, omentum, mesentery and lung. The nervous system may be a metastasis site, but with rare spinal cord involvement. This paper aims at the description of canine cutaneous hemangiosarcoma with metastasis to the central nervous system.Case: A dog presented history of skin neoplasia. The patient underwent physical examination, which detected an exophytic tumor in the foreskin. Needle aspiration of the lesion was carried out, suggesting the presence of malignant neoplasm of mesenchymal origin. So, the lesion surgical excision was the option. Before the procedure, complementary preoperative examinations of the patient were required. Those corresponded to chest radiographs, abdominal ultrasound, complete blood count, serum urea, creatinine, alanine aminotransferase, aspartate aminotransferase and total protein. The image diagnostic of the thoracic and abdominal cavities showed no noteworthy changes. The hematology and serum biochemistry were normal. The tumor obtained during surgery was sent for histopathological analysis, whose diagnosis corresponded to hemangiosarcoma. Chemotherapy treatment was not possible in the animal. Nine months after the surgery, a

RESUMO

Background: Canine hemangiosarcoma is a malignant neoplasm of endothelial cells. Such tumor has most commonly its primary location in the spleen, right atrium, subcutaneous tissue and liver. In general, metastases occur in the liver, omentum, mesentery and lung. The nervous system may be a metastasis site, but with rare spinal cord involvement. This paper aims at the description of canine cutaneous hemangiosarcoma with metastasis to the central nervous system.Case: A dog presented history of skin neoplasia. The patient underwent physical examination, which detected an exophytic tumor in the foreskin. Needle aspiration of the lesion was carried out, suggesting the presence of malignant neoplasm of mesenchymal origin. So, the lesion surgical excision was the option. Before the procedure, complementary preoperative examinations of the patient were required. Those corresponded to chest radiographs, abdominal ultrasound, complete blood count, serum urea, creatinine, alanine aminotransferase, aspartate aminotransferase and total protein. The image diagnostic of the thoracic and abdominal cavities showed no noteworthy changes. The hematology and serum biochemistry were normal. The tumor obtained during surgery was sent for histopathological analysis, whose diagnosis corresponded to hemangiosarcoma. Chemotherapy treatment was not possible in the animal. Nine months after the surgery, a

Background: Canine hemangiosarcoma is a malignant neoplasm of endothelial cells. Such tumor has most commonly its primary location in the spleen, right atrium, subcutaneous tissue and liver. In general, metastases occur in the liver, omentum, mesentery and lung. The nervous system may be a metastasis site, but with rare spinal cord involvement. This paper aims at the description of canine cutaneous hemangiosarcoma with metastasis to the central nervous system.Case: A dog presented history of skin neoplasia. The patient underwent physical examination, which detected an exophytic tumor in the foreskin. Needle aspiration of the lesion was carried out, suggesting the presence of malignant neoplasm of mesenchymal origin. So, the lesion surgical excision was the option. Before the procedure, complementary preoperative examinations of the patient were required. Those corresponded to chest radiographs, abdominal ultrasound, complete blood count, serum urea, creatinine, alanine aminotransferase, aspartate aminotransferase and total protein. The image diagnostic of the thoracic and abdominal cavities showed no noteworthy changes. The hematology and serum biochemistry were normal. The tumor obtained during surgery was sent for histopathological analysis, whose diagnosis corresponded to hemangiosarcoma. Chemotherapy treatment was not possible in the animal. Nine months after the surgery, a

RESUMO

The remaining ovary syndrome is characterized by incomplete removal of the ovaries during castration, when the remaining tissue becomes functional. Although been already described in cats, its incidence is lower in these animals when compared to humans. This study aimed to report, in a feline, a case of remaining ovary syndrome. A one-year-and-seven-month-old cat had undergone ovariectomy. After five months of surgery, the animal presented signs of rut. The patient was examined. Then, vaginal cytology was held. Exploratory laparotomy was chosen. The cat was anesthetized and the surgery began, being the material obtained sent for histopathology. The cat had normal physiological parameters. The vaginal cytology showed a pattern consistent with estrus. Laparotomy presented ovarian residue in the left pedicle. Histopathology detected the presence of cysts and follicles in different stages of development, confirming the diagnosis of remaining ovary syndrome. Though rarely reported in the feline species, this reproductive pathology diagnosis and treatment is relatively simple. Keywords: Castration, ovarian tissue, recurrent estrus, Felis catus.

A síndrome do ovário remanescente é caracterizada pela remoção incompleta do ovário durante a castração, onde o tecido residual torna-se funcional. Apesar de já ter sido descrita em gatas, a ocorrência é menor nesses animais quando comparada aos humanos. O presente trabalho objetivou relatar, em felino, um caso de síndrome do ovário remanescente. Uma gata, com um ano e sete meses, havia sido submetida à ovariectomia. Após cinco meses do procedimento cirúrgico, ocorreram sinais de cio. A paciente foi examinada. Em seguida realizou-se citologia vaginal. Optou-se por uma laparotomia exploratória. A gata foi anestesiada e iniciou-se a cirurgia, cujo material obtido foi encaminhado para histopatologia. A gata encontrava-se com os parâmetros fisiológicos normais. A citologia vaginal constatou padrão compatível com estro. Na laparotomia, havia resíduo de ovário no pedículo esquerdo. A histopatologia detectou a presença de cistos e folículos ovarianos em diferentes fases de desenvolvimento, confirmando o diagnóstico de síndrome do ovário remanescente. Embora pouco relatada na espécie felina, essa patologia reprodutiva possui diagnóstico e tratamento relativamente simples. Palavras-chave: Castração, tecido ovariano, estro recorrente, Felis catus.

RESUMO

The effect of premedication with acepromazine and xylazine was evaluated in the dissociative anesthesia of collared-pecccaries (Tayassu tajacu). Twenty one animals randomized allocated into three groups of seven individuals. Groups I and II received acepromazine (0.2 mg/Kg) and group III received xylazine (1.0 mg/Kg) by intramuscular route. After 15 minutes, diazepam 0.5 mg/Kg and ketamine (2.5 mg/Kg) were given to group I and diazepam (0.5 mg/Kg) and ketamine (5.0 mg/Kg) to groups II and III, in the same syringe, intravenously (IV). The vital functions as well as the hemogasometry were evaluated. After the anesthesia, the vital functions average were: cardiac frequency (CF) = 133.85 ± 43.31 bpm, respiratory frequency (RF) = 64.57 ± 29.61 rmpm, temperature (T) = 39.82 ± 0.73C; CF = 124.57 ± 29.43 bpm, RF = 57.28 ± 16.74 rmpm, T = 39.12 ± 0.93C; and FC = 126.85 ± 34.15 bpm, RF = 95.42 ± 25.45 rmpm, T = 39.67 ± 0.98C, for groups I, II and III, respectively. There was no significant difference in the hemogasometry. It was concluded that the tranquilization with acepromazine had highest quality. The protocols were safe, and xylazine (1.0 mg/Kg) was insufficient to sedate the animals, but association of acepromazine/ketamine (5.0 mg/Kg)/diazepam produced better results.KEY WORDS: Acepromazine, collared-peccariy, dissociative anesthesia, Tayassu tajacu, xylazine.

Avaliou-se o uso da pré-medicação com acepromazina ou xilazina na anestesia dissociativa de catetos (Tayassu Tajacu). Foram utilizados 21 animais, distribuídos em três grupos de sete indivíduos. Os grupos I e II receberam acepromazina na dose de 0,2 mg/Kg, e o grupo III recebeu xilazina na dose de 1,0 mg/Kg, por via intramuscular. Após quinze minutos, o grupo I recebeu diazepam (0,5 mg/Kg) e cetamina (2,5 mg/Kg), e os grupos II e III, diazepam (0,5 mg/Kg) e cetamina (5,0 mg/kg), na mesma seringa, por via intravenosa. Avaliaram-se funções vitais e hemogasometria. Após a anestesia, as médias das funções vitais foram: freqüência cardíaca (FC) = 133,85 ± 43,31 bpm, freqüência respiratória () = 64,57 ± 29,61 mrm e temperatura (T) = 39,82 ± 0,73C; FC = 124,57 ± 29,43 bpm, = 57,28 ± 16,74 mrm, T = 39,12 ± 0,93C; e FC = 126,85 ± 34,15 bpm, = 95,42 ± 25,45 mrpm, T = 39,67 ± 0,98C, para os grupos I, II e III respectivamente. Não houve diferença significativa na hemogasometria. Concluiu-se que a tranqüilização com acepromazina mostrou-se de melhor qualidade. Os protocolos apresentaram-se seguros, a xilazina (1,0 mg/kg) insuficiente para a indução de sedação dos animais, sendo que e a associação acepromazina/cetamina (5,0 mg/kg)/diazepam proporcionou melhores resultados.PALAVRAS-CHAVES: Acepromazina, anestesia dissociativa, cateto, Tayassu tajacu, xilazina.

RESUMO

The feline mammary hyperplasia corresponds to a dependent injury of natural or synthetic progesterone. Although it is a benign condition, the clinical presentation, many times, it is an emergency. Thus the use of immediate protocols becomes necessary, as the use of aglepristone, which corresponds to a progesterone-antagonist drug. The aim of the present study corresponded to the description a case of feline mammary hyperplasia, with therapy the base of aglepristone. A feline, female, nine months of age, it presented description of increase of mammary volume, after the administration of a dose of contraceptive (medroxyprogesterone acetate). In virtue of anamnesis and the physical examination the diagnosis of mammary hyperplasia was established and was opted to the use of aglepristone, in the posology of 10mg/kg, to each 24h, during five days, it route subcutaneous. All the mammary glands presented symmetrical hyperplasia, with firm-elastic consistency. From the third day of the administration, it was observed that the glands were with more elastic consistency and lesser volume. After 23 days of the first dose, it had complete regression of the tissue mammary and the animal was neutered. Aglepristone if disclosed as an efficient therapy and insurance. KEY WORDS: Aglepristone, feline, hyperplasia, mammary gland.

A hiperplasia mamária felina corresponde a uma lesão dependente de substâncias progestacionais naturais ou sintéticas. Embora seja uma condição benigna, a apresentação clínica, muitas vezes, é emergencial. Assim, torna-se necessário o uso de protocolos imediatos, como o uso do aglepristone, um fármaco antiprogestágeno. O presente trabalho descreveu um caso de hiperplasia mamária felina, com terapia à base de aglepristone. Um felino, fêmea, siamês, nove meses de idade, apresentou histórico de aumento de volume mamário após administração de uma dose do contraceptivo acetato de medroxiprogesterona. De acordo com a anamnese e o exame físico, foi estabelecido o diagnóstico presuntivo de hiperplasia mamária e optou-se pelo uso do aglepristone na posologia de 10 mg/kg a cada 24 horas, durante cinco dias, via subcutânea. Todos os pares de glândulas mamárias apresentavam hiperplasia simétrica, com consistência firme-elástica. A partir do terceiro dia da administração, observou-se que as glândulas estavam flácidas, consistência mais elástica e menor volume. Transcorridos 23 dias da primeira dose, constatou-se regressão completa do tecido mamário, sendo a gata  submetida à ovariossalpingo-histerectomia. O aglepristone se revelou como uma opção de tratamento eficaz e segura. PALAVRAS-CHAVES: Aglepristone, felino, glândula mamária, hiperplasia,

RESUMO

The feline mammary hyperplasia corresponds to a dependent injury of natural or synthetic progesterone. Although it is a benign condition, the clinical presentation, many times, it is an emergency. Thus the use of immediate protocols becomes necessary, as the use of aglepristone, which corresponds to a progesterone-antagonist drug. The aim of the present study corresponded to the description a case of feline mammary hyperplasia, with therapy the base of aglepristone. A feline, female, nine months of age, it presented description of increase of mammary volume, after the administration of a dose of contraceptive (medroxyprogesterone acetate). In virtue of anamnesis and the physical examination the diagnosis of mammary hyperplasia was established and was opted to the use of aglepristone, in the posology of 10mg/kg, to each 24h, during five days, it route subcutaneous. All the mammary glands presented symmetrical hyperplasia, with firm-elastic consistency. From the third day of the administration, it was observed that the glands were with more elastic consistency and lesser volume. After 23 days of the first dose, it had complete regression of the tissue mammary and the animal was neutered. Aglepristone if disclosed as an efficient therapy and insurance. KEY WORDS: Aglepristone, feline, hyperplasia, mammary gland.

A hiperplasia mamária felina corresponde a uma lesão dependente de substâncias progestacionais naturais ou sintéticas. Embora seja uma condição benigna, a apresentação clínica, muitas vezes, é emergencial. Assim, torna-se necessário o uso de protocolos imediatos, como o uso do aglepristone, um fármaco antiprogestágeno. O presente trabalho descreveu um caso de hiperplasia mamária felina, com terapia à base de aglepristone. Um felino, fêmea, siamês, nove meses de idade, apresentou histórico de aumento de volume mamário após administração de uma dose do contraceptivo acetato de medroxiprogesterona. De acordo com a anamnese e o exame físico, foi estabelecido o diagnóstico presuntivo de hiperplasia mamária e optou-se pelo uso do aglepristone na posologia de 10 mg/kg a cada 24 horas, durante cinco dias, via subcutânea. Todos os pares de glândulas mamárias apresentavam hiperplasia simétrica, com consistência firme-elástica. A partir do terceiro dia da administração, observou-se que as glândulas estavam flácidas, consistência mais elástica e menor volume. Transcorridos 23 dias da primeira dose, constatou-se regressão completa do tecido mamário, sendo a gata  submetida à ovariossalpingo-histerectomia. O aglepristone se revelou como uma opção de tratamento eficaz e segura. PALAVRAS-CHAVES: Aglepristone, felino, glândula mamária, hiperplasia,

RESUMO

The effect of premedication with acepromazine and xylazine was evaluated in the dissociative anesthesia of collared-pecccaries (Tayassu tajacu). Twenty one animals randomized allocated into three groups of seven individuals. Groups I and II received acepromazine (0.2 mg/Kg) and group III received xylazine (1.0 mg/Kg) by intramuscular route. After 15 minutes, diazepam 0.5 mg/Kg and ketamine (2.5 mg/Kg) were given to group I and diazepam (0.5 mg/Kg) and ketamine (5.0 mg/Kg) to groups II and III, in the same syringe, intravenously (IV). The vital functions as well as the hemogasometry were evaluated. After the anesthesia, the vital functions average were: cardiac frequency (CF) = 133.85 ± 43.31 bpm, respiratory frequency (RF) = 64.57 ± 29.61 rmpm, temperature (T) = 39.82 ± 0.73C; CF = 124.57 ± 29.43 bpm, RF = 57.28 ± 16.74 rmpm, T = 39.12 ± 0.93C; and FC = 126.85 ± 34.15 bpm, RF = 95.42 ± 25.45 rmpm, T = 39.67 ± 0.98C, for groups I, II and III, respectively. There was no significant difference in the hemogasometry. It was concluded that the tranquilization with acepromazine had highest quality. The protocols were safe, and xylazine (1.0 mg/Kg) was insufficient to sedate the animals, but association of acepromazine/ketamine (5.0 mg/Kg)/diazepam produced better results.KEY WORDS: Acepromazine, collared-peccariy, dissociative anesthesia, Tayassu tajacu, xylazine.

Avaliou-se o uso da pré-medicação com acepromazina ou xilazina na anestesia dissociativa de catetos (Tayassu Tajacu). Foram utilizados 21 animais, distribuídos em três grupos de sete indivíduos. Os grupos I e II receberam acepromazina na dose de 0,2 mg/Kg, e o grupo III recebeu xilazina na dose de 1,0 mg/Kg, por via intramuscular. Após quinze minutos, o grupo I recebeu diazepam (0,5 mg/Kg) e cetamina (2,5 mg/Kg), e os grupos II e III, diazepam (0,5 mg/Kg) e cetamina (5,0 mg/kg), na mesma seringa, por via intravenosa. Avaliaram-se funções vitais e hemogasometria. Após a anestesia, as médias das funções vitais foram: freqüência cardíaca (FC) = 133,85 ± 43,31 bpm, freqüência respiratória () = 64,57 ± 29,61 mrm e temperatura (T) = 39,82 ± 0,73C; FC = 124,57 ± 29,43 bpm, = 57,28 ± 16,74 mrm, T = 39,12 ± 0,93C; e FC = 126,85 ± 34,15 bpm, = 95,42 ± 25,45 mrpm, T = 39,67 ± 0,98C, para os grupos I, II e III respectivamente. Não houve diferença significativa na hemogasometria. Concluiu-se que a tranqüilização com acepromazina mostrou-se de melhor qualidade. Os protocolos apresentaram-se seguros, a xilazina (1,0 mg/kg) insuficiente para a indução de sedação dos animais, sendo que e a associação acepromazina/cetamina (5,0 mg/kg)/diazepam proporcionou melhores resultados.PALAVRAS-CHAVES: Acepromazina, anestesia dissociativa, cateto, Tayassu tajacu, xilazina.