RESUMO

The new flavonoid (-)-4'-O-methylepicatechin 5-O-ß-D-glucopyranoside (1), along with four known triterpenes (2-5), a steroid (6), and a flavonoid (7) were isolated from the ethyl acetate extract of Maytenus quadrangulata leaves. The chemical structures of the isolated compounds were determined through analysis of 1D NMR (1H and 13C) spectroscopic data, in addition to 2D NMR and spectrometric (MS) data for compound 1. This is the first report of the isolation of daucosterol (6) and (-)-4'-O-methylepigallocatechin (7) from this species. Compounds 1 and 7 were evaluated against the bacteria Staphylococcus aureus and Klebsiella pneumoniae, but neither exhibited activity even at the highest concentration tested.

Assuntos

Acetatos , Antibacterianos , Flavonoides , Klebsiella pneumoniae , Testes de Sensibilidade Microbiana , Extratos Vegetais , Folhas de Planta , Staphylococcus aureus , Triterpenos , Folhas de Planta/química , Triterpenos/química , Triterpenos/isolamento & purificação , Triterpenos/farmacologia , Flavonoides/isolamento & purificação , Flavonoides/química , Flavonoides/farmacologia , Staphylococcus aureus/efeitos dos fármacos , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/farmacologia , Klebsiella pneumoniae/efeitos dos fármacos , Acetatos/química , Antibacterianos/farmacologia , Antibacterianos/isolamento & purificação , Antibacterianos/química , Maytenus/química , Estrutura Molecular