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A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis.
Biomed Pharmacother
; 67(3): 192-6, 2013 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23433900
RESUMO
Cancer is linked to hypercoagulability, and many studies have shown that anticoagulant drugs affect tumor progression. In this study was demonstrated that the Amblyomin-X (which is a recombinant protein that exerts similarity to the Kunitz-type inhibitors and shows pro-apoptotic effects in different tumor cell lines) and heparin (a classic anticoagulant) have similar effects on cancer progression and on normalization of the hypercoagulable state. However, Amblyomin-X showed a distinct mechanism in triggering its effects in vitro, because it exerted a cytotoxic effect in cancer cells by inducing apoptosis and promoting cell cycle arrest.