Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
Pain ; 94(2): 185-191, 2001 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11690732

RESUMO

Temporomandibular joint (TMJ) pain conditions are poorly understood. Since formalin is a noxious stimulus widely used in animal behavioral experiments for studying pain mechanisms, the aim of this study was to develop a behavioral model to study the TMJ pain conditions by characterizing the nociceptive behavioral responses induced by the injection of formalin into the TMJ region of rats. NaCl (0.9%) or different concentrations of formalin (0.5, 1.5, 2.5 or 5%) were administrated into the TMJ region. The formalin-induced behavioral responses characterized by moving the mandible, rubbing the orofacial region and flinching the head quickly were quantified for 45 min. The TMJ injection of formalin significantly increased the asymmetrical orofacial rubbing and head flinching behaviors, but not the movement of the mandible with concentrations of 1.5% and above (P<0.05, Dunn's test) when compared with the NaCl (0.9%) injection. These responses were significantly reduced (P<0.05, Mann-Whitney test) by the co-application of lidocaine N-ethyl bromide quaternary salt, QX-314 (2%), and by the administration of intraperitoneal morphine (4 mg/kg) 30 min prior to the TMJ formalin injection. This study demonstrates that the injection of formalin into the TMJ region of rats produces quantitative nociceptive behaviors constituting a novel behavioral model for TMJ pain.


Assuntos
Comportamento Animal , Modelos Animais de Doenças , Lidocaína/análogos & derivados , Dor/fisiopatologia , Ratos Wistar , Articulação Temporomandibular/fisiopatologia , Analgésicos Opioides/farmacologia , Anestésicos Locais/farmacologia , Animais , Lidocaína/farmacologia , Masculino , Morfina/farmacologia , Nociceptores/fisiologia , Dor/induzido quimicamente , Dor/tratamento farmacológico , Medição da Dor , Ratos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA