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1.
Parasite Epidemiol Control ; 9: e00139, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32025581

RESUMO

Blastocystis sp. is a commonly reported intestinal parasite with a worldwide distribution. Phylogenetic analyses describe at least 17 subtypes for this parasite, and nine of them have been found in humans. However, the prevalence and some epidemiological characteristics of this parasitic infection in rural communities are not well known. The objective of this cross-sectional study was to evaluate the prevalence, subtypes, and epidemiological factors related to Blastocystis sp. Infection in children from of a small rural community in the central area of Panama. For this, 66 fecal samples from children (1 to 12 years old), were initially analyzed for the presence of parasites by a formalin-ethyl acetate/concentration method. Molecular detection and identification of Blastocystis sp. subtypes were carried out by amplification and sequencing of a partial fragment of the small-subunit ribosomal RNA gene. Using data from a questionnaire, analyses of epidemiological conditions potentially associated with Blastocystis sp. transmission were also conducted. Microscopic diagnostics showed that 33.3% (22/66) of the analyzed samples presented entero-parasites. Among them, Blastocystis sp. was the most prevalent, with 21.2% (14/66), followed by the E. histolytica/dispar/moshkovskii complex 4.5% (3/66), Giardia lamblia 1.5% (1/66) and Strongyloides stercoralis 1.5% (1/66). PCR-based analyses detected a prevalence of Blastocystis sp. infection of 74.2% (49/66) in apparently healthy children. Phylogenetic analysis revealed two different subtypes of this parasite: ST1 with 42.2% (28/66) infected, and ST3 with 31.8% (21/66) infected. In addition, recent diarrhea was significantly associated with Blastocystis sp. infection. None of the other risk factors evaluated was statistically associated with infection. These results highlight the need to further investigate clinical, epidemiological, and genetic characteristics of Blastocystis sp. infections in this community.

2.
J Expo Sci Environ Epidemiol ; 30(4): 680-688, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-31745179

RESUMO

INTRODUCTION: There have been no time-series studies of air pollution in Peru. Here we evaluate the effect of ambient PM2.5 on emergency room (ER) visits in Lima. METHODS: We estimated daily PM2.5 levels at a 1 km2 resolution during 2010-2016 using ground measurements, satellite data, and chemical transport model simulations. Population-weighted average daily PM2.5 levels were calculated for each district in Lima (n = 40), and assigned to patients based on residence. ER visits for respiratory and circulatory diseases were gathered from nine large public hospitals. Poisson regression was used to estimate the rate ratio for daily ER visits with change in daily PM2.5, controlling for meteorology, time trends, and district. RESULTS: For each interquartile range (IQR) increase in PM2.5, respiratory disease ER visits increased 4% (95% CI: 0-5%), stroke visits 10% (3-18%), and ischemic heart disease visits (adults, 18-64 years) 11% (-1, 24%). Districts with higher poverty showed significantly stronger associations of PM2.5 and respiratory disease ER visits than districts with lower poverty. Effects were diminished 24-42% using Lima-wide instead of district-specific PM2.5 levels. CONCLUSIONS: Short-term exposure to ambient PM2.5 is associated with increases in ER visits in Lima for respiratory diseases and stroke, and among middle-aged adults, ischemic heart disease.


Assuntos
Poluição do Ar/estatística & dados numéricos , Doenças Cardiovasculares/epidemiologia , Exposição Ambiental/estatística & dados numéricos , Doenças Respiratórias/epidemiologia , Adulto , Idoso , Poluentes Atmosféricos/análise , Poluição do Ar/análise , Serviço Hospitalar de Emergência/estatística & dados numéricos , Exposição Ambiental/análise , Feminino , Humanos , Masculino , Meteorologia , Pessoa de Meia-Idade , Material Particulado/análise , Peru/epidemiologia , Pobreza , Acidente Vascular Cerebral , Tempo
3.
Rev. chil. reumatol ; 36(4): 125-133, 2020. ilus, tab
Artigo em Espanhol | LILACS | ID: biblio-1282557

RESUMO

Introducción: La Fibrodisplasia osificante progresiva es una enfermedad congénita autosómica dominante poco frecuente, caracterizada por malformaciones esqueléticas y osificación heterotópica progresiva e invalidante. Caso clínico: Niño de 11 años consulta por múltiples lesiones osificadas en tronco y región cervical con importante limitación en su movilidad. En el examen físico destaca un ortejo mayor corto. Estudio genético muestra mutación del gen ACVR1. Recibe tratamiento con periodos cortos de corticosteroides posterior a traumas y previo a procedimientos, asociado a un manejo multidisciplinario. Revisión de la literatura: A la fecha el principal tratamiento es la prevención de los brotes de osificación y el uso de corticosteroides o antiinflamatorios cuando los brotes ya se iniciaron. Están en curso ensayos clínicos con bifosfonatos y anticuerpos anti-activina A. Conclusión: En la actualidad no existe un tratamiento específico, sin embargo, un diagnóstico precoz, la prevención de brotes y nuevas terapias podrían mejorar el pronóstico de los pacientes.


ntroduction: Fibrodysplasia ossificans progressiva is a rare autosomal dominant congenital disease characterized by skeletal malformations and progressive disabling heterotopic ossification. Clinical case: An 11-year-old boy consulted with multiple ossified lesions in the trunk and cervical regions associated with significant limitation in mobility. On physical examination, the big toe is short. Genetic study shows ACVR1 gene mutation. He received treatment with short corticosteroid periods after traumas and prior to clinical procedures, as well as a multidisciplinary management.Literature review: To date the main treatment is the prevention of ossification flare-ups and the use of corticosteroids or anti-inflammatories when they have already started. Clinical trials are ongoing with bisphosphonates and anti-activin A antibodies.Conclusion: There is currently no specific treatment, however, early diagnosis, prevention of flare-ups and new therapies could improve the prognosis of patients.


Assuntos
Humanos , Masculino , Criança , Ossificação Heterotópica/tratamento farmacológico , Miosite Ossificante/diagnóstico , Miosite Ossificante/terapia , Ossificação Heterotópica/diagnóstico , Corticosteroides/uso terapêutico
4.
BDJ Open ; 5: 13, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31632692

RESUMO

OBJECTIVE: Colorectal cancer (CRC) and hypodontia are frequent and different diseases with common genes are involved in their etiology. The objective of this study was to identify the association between AXIN2 rs2240308 with hypodontia and CRC. PATIENTS AND METHODS: This study consisted of 50 individuals with hypodontia, 50 individuals with CRC, and 155 healthy individuals from Colombia. SNP genotyping assays of rs2240308 were performed and family history of cancer in individuals with hypodontia was documented. In silico analysis was implemented to define the genomic profile of the AXIN2 gene associated with CRC. Multivariate analysis, chi square, odd ratio tests, and R software were used for statistical analysis. RESULTS: AXIN2 rs2240308 showed association with CRC (OR = 5.4 CI: 2.7-10.4; p < 0.001) and with other familial cancer in individuals with hypodontia (p < 0.005 OR = 1.75, 95% CI: 1.22-6.91). In silico analysis showed that variations in AXIN2 found in CRC patients, were more frequently in earlier stages of tumor and patients who carry variations in the AXIN2 gene have a worse prognosis (p < 0.05). The association between AXIN2 rs2240308 with hypodontia was not significant. CONCLUSIONS: These results suggest that AXIN2 rs2240308 polymorphism is associated with CRC and AXIN2 could be a risk marker for predisposition and prognosis of CRC.

5.
Rev Med Chil ; 142(8): 1069-75, 2014 Aug.
Artigo em Espanhol | MEDLINE | ID: mdl-25424681

RESUMO

Obesity is an important public health problem. Dietetic supplements are commonly used by obese patients who are not aware of the effectiveness or potential harms of these products. The aim of this paper is to discuss the ethical dilemma associated with the use of these supplements. The principles of autonomy, beneficence and justice are involved. Obesity as a chronic disease, requires qualified medical care. Obese individuals should be aware of their disease and voluntarily agree to receive professional care.


Assuntos
Suplementos Nutricionais , Ética Médica , Obesidade/terapia , Redução de Peso , Temas Bioéticos , Imagem Corporal , Suplementos Nutricionais/efeitos adversos , Humanos , Medição de Risco
6.
Rev. Méd. Clín. Condes ; 23(5): 530-541, sept. 2012. tab, ilus
Artigo em Espanhol | LILACS | ID: biblio-1146502

RESUMO

La neuropsicología se ha posicionado como un recurso esencial para la mayoría de las unidades de neurología, neurocirugía, psiquiatría y neurorrehabilitación, que atienden tanto a niños, adultos y adultos mayores, que padecen alteraciones del sistema nervioso central. El desafío de la neuropsicología es contribuir al proceso diagnóstico y al manejo de estos pacientes a partir de la evaluación de procesos cognitivos como atención, memoria, percepción, funciones ejecutivas, considerando sus manifestaciones conductuales y emocionales, toda vez que para la mayoría de las alteraciones neuropsiquiátricas no se cuenta con marcadores biológicos u otras técnicas que precisen el diagnóstico. Las alteraciones neuropsicológicas son manifestaciones comunes y, en algunos casos, centrales en varias de las patologías más prevalentes en neurología y psiquiatría. Este artículo presenta la definición, ámbito, objetivos y herramientas de la neuropsicología, y entrega una breve caracterización de algunos de los trastornos neuropsiquiátricos más relevantes, desde esta perspectiva.


Neuropsychology has positioned itself as an essential resource for most modern centers of neurology, neurosurgery, psychiatry and neurorehabilitation for children, adults and seniors suffering from central nervous system disorders. Its challenge is to help in the diagnosis and management of these patients through the evaluation of cognitive processes, such as: Attention, memory, perception, executive functions; taking into account behavioral and emotional expressions - since most neuropsychiatric disorders have no biological markers; and we have no other techniques that provide accurate diagnoses. Neuropsychological disturbances are common, and in some cases, the main clinical manifestation in these disorders. This paper discusses the definition, scope, objectives, and tools of neuropsychology. It also provides a brief description of some relevant neuropsychiatric disorders through this perspective.


Assuntos
Humanos , Criança , Adulto , Idoso , Transtornos Mentais/diagnóstico , Neuropsicologia/métodos , Desempenho Psicomotor/fisiologia , Cognição/fisiologia , Transtornos Neurocognitivos , Demência , Transtornos da Memória , Doenças do Sistema Nervoso/diagnóstico , Testes Neuropsicológicos
7.
Arch. latinoam. nutr ; Arch. latinoam. nutr;62(2): 155-160, jun. 2012. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-710616

RESUMO

La historia familiar (HF) de Enfermedades Crónicas no Transmisibles (ECNT), aumentaría el riesgo de síndrome metabólico (SM). En Chile, el SM afecta al 27% de niños con sobrepeso, y la hiperglicemia de ayuno (HA) es el trastorno menos prevalente (4.0%). El objetivo fue estudiar la prevalencia del SM y de los factores de riesgo cardiovascular (FRCV) en niños con sobrepeso e HF de ECNT analizando su asociación con el número de parientes afectados y con la historia parental (HP). En 183 niños con IMC ≥p85 de 11,8 ± 1,8 años (86 varones) e HF (padres y/o abuelos) de ECNT, se evaluó el z IMC (CDC / NCHS), el perímetro de cintura, la presión arterial, la glicemia, la insulina, los triglicéridos y el colesterol-HDL. El SM y los FRCV fueron diagnosticados por el criterio de Cook y la insulinoresistencia (IR) por el HOMA-IR. Se utilizaron Chi², ANOVA, t Student y Willcoxon. La HF de DM2, hipertensión arterial y dislipidemia fue de 81,4 %, 88,0 % y 71,6 % respectivamente. La prevalencia del SM fue de 46,5%, asociándose a la magnitud del sobrepeso y a la HP de ECNT. La prevalencia de hipertrigliceridemia y de hiperglicemia de ayuno fueron de 54,6% y 31,4% respectivamente. No hubo asociación entre el número de parientes con HF y el perfil cardiovascular y metabólico del niño. Se concluye, que la HF de ECNT, se asocia a una mayor prevalencia del SM, de dislipidemia y de hiperglicemia de ayuno que la observada en población general de niños con sobrepeso.


Metabolic syndrome prevalence in Chilean children and adolescent with family history of chronic noncommunicable diseases. . Family history (FH+) of non transmisible chronic diseases (NTCD) increase MetS risk. In Chile, the MetS affects 27% of overweight children, and fasting hyperglycemia is very low prevalent (4,0%). The objective was to study the prevalence of MetS and the cardiovascular risk factors (CVRF) in overweight children with a family background of NTCD and analyze its association with the number of relatives witth NTCD and with parental history (PH). In 183 overweight children (BMI ≥p85) mean age 11,8 ± 1,8 (86 males) with a FH+ (parental or grandparental) of NTCD, were assessed the BMI z (CDC / NCHS), waist circumference, blood arterial pressure, fasting Glucose and Insulin (RIA), triglycerides, HDL chol. The MetS and the CVRF were diagnosed using the Cook phenotype and the insulin resistance (IR) through the HOMA-IR. Chi², ANOVA, t Student and Willcoxon test were performed. The frequency of FH+ of DM2, hypertension and dyslipidemia were 81,4 %, 88,0 % and 71,6 % respectively. The MeTS prevalence was 46,5 % associated to overweight magnitude an parental history of NTCD. The prevalence of hypertriglyceridemia was 54,6%, while fasting hyperglycemia affected 31,4% of the sample. There was no association between number of relatives with NTCD and CV risk profile. We conclude that in overweight children with FH+ of NTCD, the prevalence of MetS, dyslipidemia and fasting hyperglycemia are significantly higher, than those observed in the general population of obese children.


Assuntos
Adolescente , Criança , Feminino , Humanos , Masculino , Doenças Cardiovasculares/genética , Hipoglicemia/epidemiologia , Síndrome Metabólica/epidemiologia , Glicemia/análise , Doença Crônica , Chile/epidemiologia , Colesterol/sangue , Complicações do Diabetes , Suscetibilidade a Doenças , Dislipidemias/epidemiologia , Família , Resistência à Insulina/fisiologia , Anamnese , Sobrepeso/complicações , Prevalência , Fatores de Risco
8.
Cuad. méd.-soc. (Santiago de Chile) ; 52(2): 11-26, 2012. tab, graf
Artigo em Espanhol | LILACS | ID: lil-691020

RESUMO

Con el propósito de volver a la integralidad de la APS, la comuna de Curarrehue desde el año 2010 está impulsando la estrategia “Salud en tu Casa”, la cual es una herramienta que apunta hacia el desarrollo local donde, a través del trabajo transdisciplinario, fundamentado en la intersectorialidad, el trabajo comunitario y el aumento del capital social, ha puesto en el eje del sistema de salud la promoción y la prevención de manera real y en su amplio sentido, fundamentado en el abordaje de los determinantes sociales de la salud. Se expone el proceso que ha llevado adelante el equipo de salud local de Curarrehue en la tarea de reorientar la APS de la comuna desde el enfoque de determinantes sociales de la salud.


Since 2010, Curarrehue, a small town in the south of Chile, is driving an strategy called “Health at Home” in order to return to the comprehensive model of Primary Health Care. This is a tool aimed at local development through transdisciplinary work, intersectorial action, community work and increased social capital. Its axis has been health promotion and prevention based on addressing the social determinants of health. The process that has been driven by the local health team of Curarrehue in the task of reorienting the Primary Health Care in view of the social determinants of health, is here presented.


Assuntos
Atenção Primária à Saúde/organização & administração , Equidade em Saúde , Promoção da Saúde , Participação da Comunidade , Colaboração Intersetorial , Atenção Primária à Saúde/métodos , Chile , Saúde da Família , Fatores Socioeconômicos , Serviços de Saúde Comunitária/organização & administração
10.
Rev. gastroenterol. Perú ; 31(2): 146-150, abr.-jun. 2011. tab
Artigo em Espanhol | LILACS, LIPECS | ID: lil-597276

RESUMO

OBJETIVO: Evaluar si la administración de nutrición enteral precoz en el post operatorio de los pacientes gastrectomizados por cáncer gástrico contribuye a disminuir la frecuencia de complicaciones post operatorias. MATERIALES Y MÉTODOS: Se realizó un estudio de casos y controles con 120 pacientes, 60 con complicaciones post-operatorias (casos) y 60 pacientes sin complicaciones postoperatorias (controles), pareados por edad y sexo. RESULTADOS: El análisis univariado, encontró que albúmina (p=0.03), hematocrito (p=0.004), nutrición enteral precoz (p<0.01), estadío del cáncer gástrico (p=0.013) se comportaron como variables asociadas al desarrollo de complicaciones post-operatorias; sin embargo, en el análisis múltivariado, sólo la nutrición enteral precoz (p=0.014), nivel de hematocrito (0.019) y estadio anatomopatológico (0.013) mostraron asociación estadística significativa. CONCLUSIONES: La nutrición enteral precoz administrada por sonda nasoenteral en el post-operatorio inmediato, junto con el nivel de hematocrito y estadio anátomo-patológico de la enfermedad, se asociaron estadísticamente a la disminución de las complicaciones postoperatorias, en pacientes sometidos a cirugía radical, por cáncer gástrico.


OBJECTIVE: To evaluate whether the administration of early enteral nutrition in postoperative gastrectomized patients due gastric cancer helps to reduce the frequency of postoperative complications. MATERIALS AND METHODS: A case-control study with 120 patients, 60 with postoperative complications (cases) and 60 patients without post operative complications (controls) matched for age and sex. RESULTS: The uni-variable analysis found that albumin (p=0.03), hematocrit (p=0.004), early enteral nutrition (p<0.01), stage of gastric cancer (p=0.013), behaved as variables associated with the development of postoperative complications. However, in this multivariable analysis, only early enteral nutrition (p=0.014), hematocrit (0.019) and pathological stage (0.013), showed statistically significant association. CONCLUSIONS: The early enteral nutrition administered by nasoenteral tube in the immediate postoperative period, with the hematocrit level and the anatomopathological disease stage is associated with statistically decreased postoperative complications in patients undergoing radical surgery for gastric cancer.


Assuntos
Humanos , Masculino , Feminino , Neoplasias Gástricas , Nutrição Enteral , Síndromes Pós-Gastrectomia/complicações , Síndromes Pós-Gastrectomia/prevenção & controle , Estudos de Casos e Controles
11.
Rev. chil. cir ; 63(2): 186-190, abr. 2011. ilus
Artigo em Espanhol | LILACS | ID: lil-582970

RESUMO

The use of antibiotic prophylaxis has been questioned in the inguinal herniorrhaphy with mesh. The aim of this paper is to give account of the efficiency of antibiotic prophylaxis (AP) in the prevention of wound infection in the elective inguinal herniorrhaphy with mesh under local anaesthesia in an ambulatory basis. In the present observacional analytic study, 955 patients were operated upon with a mesh technique during a 10 year period, .in the CRS Hernia Centre in Santiago. In the first group of 250 patients, lgr Cefazolin® was administered iv one hour before the operation, in the second group of 710 patients no antibiotics were used. Demographic variables, associated diseases, the length of surgery were comparable in both groups. The same team of surgeons work in both groups. Wound infection was defined as the presence of pus in the surgical wound associated with a positive bacterial culture. The rate of wound infections was 1.05 percent of the first and 0.35 percent of the second group. This difference was no significant (p < 0.08). The isolated germ was a Staphylo-coccus aureus in all cases. The treatment was ambulatory in all cases. The rate of haematoma and funiculo-testicular fluxion were low. We conclude that the rate of wound infection in mesh herniorrhaphies is low and that the antibiotic prophylaxis does not improve these results. Its routine use in these patients is not justified.


Introducción: El uso de la profilaxis antibiótica en la cirugía hemiaria con malla es controversial. El propósito del presente estudio es establecer la efectividad de la profilaxis antibiótica (PA) en la prevención de la infección del sitio operatorio (ISO) en la herniorrafía con malla efectuada en forma ambulatoria con anestesia local. Material y Método: El estudio observacional analítico se realizó dentro del Programa de Cirugía Ambulatoria del CRS Cordillera, en dos grupos consecutivos de pacientes, el primero que se sometió a PA mediante lgr de Cefazolina® intravenosa, inmediatamente antes del procedimiento quirúrgico, y el segundo en el que se prescindió de ella. Los controles postoperatorios se efectuaron al 7º y 30º día por un cirujano del grupo. Se diagnosticó ISO con la presencia de exudado purulento, con cultivo bacteriano positivo. Resultados: El estudio se efectuó en 955 pacientes operados entre 1998 y 2008. En el primer grupo, constituido por 245 pacientes se usó PA, en el segundo grupo de 710 pacientes se prescindió de ella. Las variables demográficas, antecedentes mórbidos y la duración del acto quirúrgico fueron comparables en ambos grupos. Se registraron 2 casos de infección en el primer grupo (1,05 por ciento) y dos en el segundo (0,35). Esta diferencia no fue significativa. El germen aislado fue en todos los casos el estafilococo dorado. Conclusiones: La tasa ISO en la hemiorrafia inguinal electiva ambulatoria con malla es baja y no se modificó con el uso de PA. Su empleo indiscriminado no aparece justificado en estos pacientes.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Antibioticoprofilaxia , Hérnia Inguinal/cirurgia , Infecção da Ferida Cirúrgica/prevenção & controle , Procedimentos Cirúrgicos Operatórios/efeitos adversos , Procedimentos Cirúrgicos Operatórios/métodos , Telas Cirúrgicas , Procedimentos Cirúrgicos Ambulatórios , Anestesia Local , Antibacterianos/uso terapêutico , Distribuição de Qui-Quadrado , Cefazolina/uso terapêutico , Infecção da Ferida Cirúrgica/epidemiologia , Estudos Observacionais como Assunto , Complicações Pós-Operatórias
12.
Rev Med Chil ; 137(5): 657-65, 2009 May.
Artigo em Espanhol | MEDLINE | ID: mdl-19701555

RESUMO

BACKGROUND: Six percent of the Chilean population has a disability requiring assistance with daily-living-activities and 69% of these individuals are cared by direct family members. The latter are at risk of developing caregiver burden. Zarit scales are used to assess the severity of caregiver burden. AIM: To validate the original and abbreviated Zarit scales for caregiver burden. MATERIAL AND METHODS: Two groups of interviewers applied the original and abbreviated Zarit scales, along with a single subjective indicator for burden and surveys for depression, to 32 caregivers from an outpatient clinic in Melipilla, Chile. In 22 subjects, the instruments were applied again, four months later RESULTS: Both Zarit scales showed high correlation with the subjective indicator for burden and with depression (r =0.51 and 0.67, respectively), supporting its construct validity. The abbreviated scale had a high correlation with the original scale (r =0.92), supporting its criterion validity. It had a 100 % sensitivity 77.7%, specificity 86.6% positive predictive value and 100% negative predictive value to discriminate severe caregiver burden, using the original scale as standard. Both instruments showed high internal consistency (Cronbach alpha =0.84 and 0.87, respectively), inter-observer reliability (intraclass correlation coefficient =0.81 and 0.86, respectively) and stability reliability (Kappa test-retest =0.91 and 0.93, respectively). CONCLUSIONS: Both original and abbreviated Zarit burden scales are valid to assess caregiver's burden in a Chilean context. The abbreviate scale Szeged particularly useful for primary care.


Assuntos
Cuidadores/psicologia , Efeitos Psicossociais da Doença , Escalas de Graduação Psiquiátrica , Inquéritos e Questionários , Chile , Família , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Psicometria , Sensibilidade e Especificidade , Carga de Trabalho
13.
Rev. méd. Chile ; 137(5): 657-665, mayo 2009. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-521868

RESUMO

Background: Six percent of the Chilean population has a disability requiring assistance with daily-living-activities and 69 percent of these individuals are cared by direct family members. The latter are at risk of developing caregiver burden. Zarit scales are used to assess the severity of caregiver burden. Aim: To validate the original and abbreviated Zarit scales for caregiver burden. Material and methods: Two groups of interviewers applied the original and abbreviated Zarit scales, along with a single subjective indicator for burden and surveys for depression, to 32 caregivers from an outpatient clinic in Melipilla, Chile. In 22 subjects, the instruments were applied again, four months later Results: Both Zarit scales showed high correlation with the subjective indicator for burden and with depression (r =0.51 and 0.67, respectively), supporting its construct validity. The abbreviated scale had a high correlation with the original scale (r =0.92), supporting its criterion validity. It had a 100 percent sensitivity 77.7 percent, specificity 86.6 percent positive predictive value and 100 percent negative predictive value to discriminate severe caregiver burden, using the original scale as standard. Both instruments showed high internal consistency (Cronbach alpha =0.84 and 0.87, respectively), inter-observer reliability (intraclass correlation coefficient =0.81 and 0.86, respectively) and stability reliability (Kappa test-retest =0.91 and 0.93, respectively). Conclusions: Both original and abbreviated Zarit burden scales are valid to assess caregiver's burden in a Chilean context. The abreviate scale Szeged particularly useful for primary care.


Assuntos
Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Cuidadores/psicologia , Efeitos Psicossociais da Doença , Escalas de Graduação Psiquiátrica , Inquéritos e Questionários , Chile , Família , Valor Preditivo dos Testes , Psicometria , Sensibilidade e Especificidade , Carga de Trabalho
14.
Rev Chilena Infectol ; 25(2): S14-8, 2008 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-18425218

RESUMO

Rabies glycoprotein is the only exposed protein which is inserted in the viral lipidie envelope. This 65-67 kda protein is a N-glycosilated transmembrane protein forming trimers on the viral surface. It has been identified as the major pathogenicity determinant, playing a role in the budding, viral axonal transport during infection, apoptosis and immune evasion. It is also the major antigen responsible for the protective immune response and it is been used in commercial recombinant vaccines. Its structure, antigenicity and pathogenic role have been well studied, identifying main antigenic sites that have the responsibility for virulence, cellular receptors attachment and epitope acquisition.


Assuntos
Antígenos Virais , Glicoproteínas , Vírus da Raiva/patogenicidade , Proteínas do Envelope Viral , Animais , Antígenos Virais/química , Antígenos Virais/imunologia , Antígenos Virais/fisiologia , Glicoproteínas/química , Glicoproteínas/imunologia , Glicoproteínas/fisiologia , Humanos , Conformação Proteica , Vírus da Raiva/imunologia , Vírus da Raiva/metabolismo , Proteínas do Envelope Viral/química , Proteínas do Envelope Viral/imunologia , Proteínas do Envelope Viral/fisiologia , Virulência
15.
Rev. chil. infectol ; Rev. chil. infectol;25(supl.1): S14-S18, abr. 2008.
Artigo em Espanhol | LILACS | ID: lil-480661

RESUMO

Rabies glycoprotein is the only exposed protein which is inserted in the viral lipidie envelope. This 65-67 kda protein is a N-glycosilated transmembrane protein forming trimers on the viral surface. It has been identified as the major pathogenicity determinant, playing a role in the budding, viral axonal transport during infection, apoptosis and immune evasion. It is also the major antigen responsible for the protective immune response and it is been used in commercial recombinant vaccines. Its structure, antigenicity and pathogenic role have been well studied, identifying main antigenic sites that have the responsibility for virulence, cellular receptors attachment and epitope acquisition.


La glicoproteína del virus rábico es la única proteína viral expuesta, encontrándose inserta en la envoltura lipídica. Esta molécula de 65-67 kda corresponde a una proteína trans-membrana N-glicosilada que se dispone en forma de trímeros en la superficie viral. Ha sido identificada como el mayor determinante de pato-genicidad, participando además en procesos de yemación, flujo axonal del virion durante la infección, apoptosis y evasión de la respuesta inmune. Es también el principal antígeno inductor de la respuesta inmune protectora siendo utilizado en vacunas recom-binantes comerciales. Su estructura, antigenicidad e implicancias en la patogenia han sido bien estudiadas identificándose los principales sitios antigénicos responsables de la patogenicidad, unión a receptores celulares y formación de epitopos.


Assuntos
Animais , Humanos , Antígenos Virais , Glicoproteínas , Vírus da Raiva/patogenicidade , Proteínas do Envelope Viral , Antígenos Virais/química , Antígenos Virais/imunologia , Antígenos Virais/fisiologia , Glicoproteínas/química , Glicoproteínas/imunologia , Glicoproteínas/fisiologia , Conformação Proteica , Vírus da Raiva/imunologia , Vírus da Raiva/metabolismo , Virulência , Proteínas do Envelope Viral/química , Proteínas do Envelope Viral/imunologia , Proteínas do Envelope Viral/fisiologia
16.
Correo poblac ; 16(1): 5-17, mar. 2008.
Artigo em Espanhol | LILACS | ID: lil-573085
17.
Rev. chil. neuro-psiquiatr ; Rev. chil. neuro-psiquiatr;45(1): 43-50, mar. 2007. ilus
Artigo em Espanhol | LILACS | ID: lil-476932

RESUMO

Se presenta el caso de un hombre de 57 años que presenta un cuadro degenerativo con afasia fluente y moderadas alteraciones de conducta, sin defecto semántico significativo, agnosia visual ni agrafia lexical y su estudio imagenológico cerebral. Se discuten los conceptos de afasia progresiva fluente y demencia semántica, concluyendo que la primera puede evolucionar hacia esta última. Nuestro caso se encontraría en esta situación. Se señala que la patología de las afasias progresivas es variable, siendo lo más frecuente una degeneración frontotemporal (con o sin inclusiones de proteína tau); con menor frecuencia corresponde a una enfermedad de Alzheimer o una degeneración corticobasal.


We report a 57-year-old man presenting with progressive fluent aphasia and behaviour disorder, with no visual semantic loss, visual agnosia, lexical agraphia, nor alexia. We include in this report the brain images, and we discuss the borders between fluent progressive aphasia and semantic dementia. We conclude that fluent progressive aphasia may be the first stage of semantic dementia, noting that the neuropathology of progressive fluent aphasia usually corresponds to frontotemporal lobar degeneration, with or without Tau protein inclusions, as in Alzheimer's Disease or corticobasal degeneration.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Afasia Primária Progressiva/etiologia , Demência , Doença de Alzheimer/etiologia , Semântica , Transtornos da Linguagem/etiologia , Agnosia/diagnóstico , Agnosia/etiologia , Transtornos Mentais , Comportamento Social
18.
Rev. Soc. Boliv. Pediatr ; 46(3): 199-208, 2007. graf
Artigo em Espanhol | LILACS | ID: lil-499162

RESUMO

En Chile, se ha producido un incremento importante de la obesidad como consecuencia de una acelerada transición nutricional, pasando rápidamente de una situación de pre-transición -con predominio de la desnutrición como principal problema de salud pública-a uno de post-transición, con predominio de la obesidad. Esta situación se ha observado principalmente en niños, adultos y embarazadas.


Assuntos
Criança , Composição Corporal , Transtornos da Nutrição Infantil , Obesidade/prevenção & controle , Atividade Motora/fisiologia , Peso Corporal , Desnutrição
19.
Rev. chil. nutr ; 32(2): 110-117, ago. 2005. tab, graf
Artigo em Espanhol | LILACS | ID: lil-476883

RESUMO

Objetivo: Evaluar el nivel de actividad física de un grupo de preescolares obesos entre 3 y 5 años asistentes a los jardines infantiles JUNJI. Métodos: El tamaño muestral estuvo constituido de 24 niños obesos de 3 a 5 años, con una distribución del 50 por ciento según sexo. Se utilizó un sensor de movimiento (Tritrac-R3D) durante dos días de la semana (S) tanto en el jardín infantil como en la casa y un día de fin de semana (FS). Las categorías de actividad física, fueron clasificadas en mínima, sedentaria, leve y moderada, de acuerdo a puntos de corte ya establecidos. Resultados: En S, el mayor porcentaje del tiempo es dedicado a actividad mínima: 58 por ciento (488 minutos) y sólo un 4 por ciento (32 min.) a actividad moderada-intensa. En FS la actividad mínima alcanza el 52 por ciento (405 min.) y la moderada-intensa sólo el 3 por ciento (22 min.). Conclusiones: Los resultados indican que estos niños tienen un patrón similar en el jardín infantil y hogar. Se encuentran en curso iniciativas para incluir actividades que desarrollen estilos de vida más activos en los niños (Proyecto ICENAF).


Objective: To evaluate the level of physical activity in a group of obese preschool children between 3 and 5 years-old attending daycare centers (JUNJI). Methods: The sample was constituted by 24 obese children of 3-5 year old, with a homogeneous distribution. A movement sensor (Tritrac-R3D) was used during two days of week (W) in the daycare center and home at one weekend (WEND) day, to assess the following activity categories: minimum, sedentary, light and moderate-intense. Results: In the W, children spent the greatest percentage of time, in minimal activity 58 percent (488 minutes) and only 4 percent (32 minutes) in moderate-intense activity. At a WEND day, minimal activity was 52 percent (405 minutes) and moderate-intense activity was 3 percent (22 minutes). Conclusions: This group of obese preschool children has a sedentary pattern of physical activity, both at home and day care center. Initiatives are under way to ameliorate the type of activities which promote more active lifestyles in the children (ICENAF Project).


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Atividade Motora , Obesidade , Chile , Exercício Físico , Equipamentos de Medição de Riscos , Interpretação Estatística de Dados
20.
Rev. chil. pediatr ; 76(3): 266-274, mayo 2005. tab, graf
Artigo em Espanhol | LILACS | ID: lil-432980

RESUMO

Objetivo: Comparar balance energético, composición corporal y actividad física en párvulos eutróficos y obesos, de 3 a 5 años, asistentes a jardines infantiles JUNJI. Metodología: Se compararon entre eutróficos y obesos: el gasto energético total (GET) con agua doblemente marcada (ADM); la ingesta energética (IE) por pesaje en jardín y registro en el hogar, más la actividad física en jardín con sensor de movimiento TRITRAC. Resultados: GET fue mayor en niños obesos (p = 0,006). IE en el jardín fue mayor para obesos de ambos sexos (p = 0,0001), IE en el hogar (semana) fue mayor en niños obesos (p = 0,0001) y en fin de semana IE fue mayor en niñas y niños obesos (p = 0,0001). En actividad física en el jardín, los niños eutróficos tuvieron mayor actividad moderada intensa (p = 0,02). Conclusiones: El hogar condiciona una mayor ingesta energía de los niños obesos. La actividad física tiende a ser sedentaria en el jardín infantil. Un proceso de intervención educativa que busque cambiar esta situación, debe considerar a la familia y educadores.


Assuntos
Masculino , Humanos , Feminino , Pré-Escolar , Composição Corporal , Exercício Físico/fisiologia , Ingestão de Energia/fisiologia , Metabolismo Energético/fisiologia , Obesidade/metabolismo , Pesos e Medidas Corporais/estatística & dados numéricos , Chile , Monitorização Fisiológica/métodos , Estatísticas não Paramétricas
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