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Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. It progresses from simple steatosis to non-alcoholic steatohepatitis (NASH). Fibrosis is often present during NAFLD progression; however, factors determining which subjects develop NASH or fibrosis are unclear. Insulin-like growth factor binding proteins (IGFBPs) are a family of secreted proteins involved in senescence and scarring, mainly synthetized in the liver. Here, we aimed to study the association of IGFBPs and their induced senescence with the progression of NAFLD and liver fibrosis. Materials and Methods: A total of 16-week-old male C57BL/6 mice weighing 23 ± 3 g were fed either methionine/choline-deficient (MCD) or control diet for 2, 8, or 12 weeks. Blood and liver samples were collected, and a histological assessment of NAFLD and fibrosis was performed. Fat contents were measured. Cellular senescence was evaluated in the liver. IGFBP levels were assessed in the liver and serum. Data were expressed as mean ± SD and analyzed by a one-way ANOVA followed by Tukey's test. Lineal regression models were applied for NAFLD and fibrosis progression. p < 0.05 was considered significant. Results: IGFBP-1 and -2 were increased in serum during NAFLD. IGFBP-7 was significantly increased in the serum in NASH compared with the controls. Senescence increased in NAFLD. Serum and liver IGFBP-7 as well as SA-ß-gal activity increased as fibrosis progressed. Both IGFBP-7 and cellular senescence were significantly higher during NAFLD and fibrosis in MCD-fed mice. Conclusions: IGFBP-1, -2, and -7, through their consequent senescence, have a role in the progression of NAFLD and its associated fibrosis, being a plausible determinant in the progression from steatosis to NASH.
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Hepatopatia Gordurosa não Alcoólica , Masculino , Humanos , Camundongos , Animais , Hepatopatia Gordurosa não Alcoólica/complicações , Proteína 1 de Ligação a Fator de Crescimento Semelhante à Insulina , Peptídeos Semelhantes à Insulina , Camundongos Endogâmicos C57BL , Fígado , Cirrose Hepática/complicações , Colina/metabolismo , Colina/farmacologia , Senescência Celular , Modelos Animais de DoençasRESUMO
Los gases arteriales son herramientas fundamentales para evaluar objetivamente a pacientes con patologías agudas y crónicas, dado que proporcionan información sobre los índices de oxigenación, ventilación, equilibrio ácido-base y el suministro de oxígeno a nivel celular. Interpretarlos adecuadamente tiene gran importancia clínica, dado que influye en la toma de decisiones permite evaluar la respuesta a intervenciones terapéuticas. Este artículo tiene como objetivo presentar al lector los conceptos básicos de la fisiología del intercambio gaseoso, los trastornos ácido-base más comunes y una interpretación práctica de los gases arteriales. Se utiliza una combinación de ilustraciones gráficas, tablas y algoritmos para facilitar la comprensión y el abordaje clínico de pacientes con alteraciones respiratorias y metabólicas. Palabras clave: gasometría arterial; fisiología oxigenación; alcalosis; acidosis
Arterial blood gases are fundamental tools to objectively evaluate patients with acute and chronic pathologies. They provide information on rates of oxygenation, ventilation, acid-base balance,and oxygen supply at the cellular level. Interpreting them properly is of great clinical importance for making timely decisions and allows evaluating the response to therapeutic interventions. This article introduces to the reader to the basic concepts ofgas exchange physiology, the most common acid-base disorders, and a practical interpretation of arterial blood gases. A combination of graphic illustrations, tables, and algorithms is used to facilitate the understanding and clinical management of patients with respiratory and metabolic disorders. Key words:blood gas analysis; physiology oxygenation; alkalosis; acidosis
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Gasometria , Acidose , Oxigenação , AlcaloseRESUMO
The coronavirus (COVID-19) pandemic, confinement, fear, lifestyle changes, and worldwide health care impacted almost all diseases. Reports from countries outside Latin America revealed differences in migraine patients. In this study, we describe and compare the immediate changes in migraine symptoms associated with COVID-19 quarantine in patients from Argentina, Mexico, and Peru. An online survey was conducted from May to July 2020. The survey was answered by 243 migraine patients, with questions related to sociodemographic data, quarantine conditions, changes in working conditions, physical activity, coffee intake, healthcare access, acute migraine medication use, symptoms of anxiety, depression, and fear of COVID-19. The results show that 48.6% of migraine patients experienced worsened symptoms, 15.6% improved, and 35.8% remained unchanged. Worsening migraine symptoms were associated with staying at home during the lockdown. Intake of analgesics was associated with an increase in migraine symptoms of 18 times relative to those who did not increase their intake. Migraine symptoms improved when the number of sleep hours was increased, and we observed an improvement when patients decreased analgesic intake. The uncertainty about the end of the pandemic, the news, and social media are three items that contributed to the worsening of migraine symptoms in patients in the three investigated countries. Confinement during the first pandemic wave in Latin America harmed migraine patients who stayed home during the lockdown.
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COVID-19 , Transtornos de Enxaqueca , Humanos , Pandemias , América Latina , SARS-CoV-2 , Controle de Doenças Transmissíveis , Acessibilidade aos Serviços de Saúde , Analgésicos/uso terapêutico , Transtornos de Enxaqueca/tratamento farmacológicoRESUMO
Computerized cognitive training tools are an alternative to preventive treatments related to cognitive impairment and aging. In this study, the transfer of 3D multiple object tracking (3D-MOT) training on manual dexterity concerning fine and gross motor skills in 38 elderly participants, half of them with mild cognitive impairment (MCI) and the other half with mild dementia (MD) was explored. A total of 36 sessions of the 3D-MOT training program were administered to the subjects. The Montreal Cognitive Assessment (MoCA) test was used to assess the baseline cognitive status of the participants. Two batteries of manual motor skills (GPT and MMDT) were applied before and after the 3D-MOT training program. The results showed an interaction effect of training and improvement in manual dexterity tests, from the first training session until the fifteenth session, and after this range of sessions, the interaction effect was lost. However, the training effect continued to the end of the thirty-six-session program. The experimental results show the effect of cognitive training on the improvement of motor skills in older adults. This type of intervention could have a broad impact on the aging population in terms of their attention, executive functions, and therefore, their quality of life.
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OBJECTIVE: To determine the incidence of postintensive care syndrome in a cohort of critically ill patients admitted to the intensive care unit and to identify risk factors related to its development in the physical, cognitive and mental health areas. METHODS: This was a prospective observational cohort study developed in the intensive care unit of a university hospital. Patients with intensive care unit stays equal to or longer than one week and the need for mechanical ventilation for more than 3 days, shock or delirium were included in the study. Demographic variables, reasons for admission, diagnoses, sedation, type of mechanical ventilation used, complications and length of stay were recorded. A univariate analysis was performed to identify risk factors related to postintensive care syndrome. The scales used for the assessment of the different spheres were Barthel, Pfeiffer, Hospital Anxiety and Depression Scale and Impact of Event Scale-6. The main variables of interest were postintensive care syndrome incidence overall and by domains. Risk factors were examined in each of the health domains (physical, cognitive and mental health). RESULTS: Eighty-seven patients were included. The mean Acute Physiology and Chronic Health Evaluation II score was 16.5. The mean number of intensive care unit days was 17. The incidence of global postintensive care syndrome was 56.3% (n = 49, 95%CI 45.8 - 66.2%). The incidence of postintensive care syndrome in each of the spheres was 32.1% (physical), 11.5% (cognitive), and 36.6% (mental health). CONCLUSIONS: The incidence of postintensive care syndrome is 56.3%. The mental health sphere is the most frequently involved. The risk factors are different depending on the area considered.
OBJETIVO: Determinar a incidência da síndrome pós-cuidados intensivos em uma coorte de pacientes em estado crítico admitidos à unidade de terapia intensiva e identificar fatores de risco relacionados ao seu desenvolvimento nas áreas de saúde física, cognitiva e mental. MÉTODOS: Este foi um estudo de coorte observacional prospectivo desenvolvido na unidade de terapia intensiva de um hospital universitário. Foram incluídos no estudo pacientes internados em unidade de terapia intensiva a partir de 1 semana e com necessidade de ventilação mecânica por mais de 3 dias, choque ou delirium. Foram registradas variáveis demográficas, motivo da admissão, diagnósticos, sedação, tipo de ventilação mecânica, complicações e tempo de internação. Realizou-se análise univariada para identificar os fatores de risco relacionados à síndrome pós-cuidados intensivos. As escalas utilizadas para a avaliação das diferentes esferas foram Barthel, Pfeiffer, Hospital Anxiety and Depression Scale e Impact of Event Scale-6. As principais variáveis de interesse foram incidência da síndrome pós-cuidados intensivos de modo geral e por domínios. Os fatores de risco foram examinados em cada um dos domínios da saúde (saúde física, cognitiva e mental). RESULTADOS: Participaram 87 pacientes. A Acute Physiology and Chronic Health Evaluation II média foi de 16,5. O número médio de dias na unidade de terapia intensiva foi 17. A incidência geral da síndrome pós-cuidados intensivos foi de 56,3% (n = 49; IC95% 45,8 - 66,2). A incidência da síndrome pós-cuidados intensivos em cada uma das esferas foi de 32,1% (física), 11,5% (cognitiva) e 36,6% (saúde mental). CONCLUSÃO: A incidência da síndrome pós-cuidados intensivos foi de 56,3%. A esfera da saúde mental foi a mais frequentemente envolvida. Os fatores de risco diferem, dependendo da área considerada.
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Estado Terminal , Unidades de Terapia Intensiva , Humanos , Estado Terminal/psicologia , Incidência , Estudos Prospectivos , Respiração Artificial , Estudos de Coortes , Fatores de RiscoAssuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Unidades de Terapia Intensiva , Cuidados de Enfermagem/métodos , Cuidados de Enfermagem/normas , Inquéritos e Questionários , Avaliação de Processos em Cuidados de Saúde , Enfermeiras e Enfermeiros , Cuidados de Enfermagem/estatística & dados numéricosRESUMO
RESUMO Objetivo: Determinar a incidência da síndrome pós-cuidados intensivos em uma coorte de pacientes em estado crítico admitidos à unidade de terapia intensiva e identificar fatores de risco relacionados ao seu desenvolvimento nas áreas de saúde física, cognitiva e mental. Métodos: Este foi um estudo de coorte observacional prospectivo desenvolvido na unidade de terapia intensiva de um hospital universitário. Foram incluídos no estudo pacientes internados em unidade de terapia intensiva a partir de 1 semana e com necessidade de ventilação mecânica por mais de 3 dias, choque ou delirium. Foram registradas variáveis demográficas, motivo da admissão, diagnósticos, sedação, tipo de ventilação mecânica, complicações e tempo de internação. Realizou-se análise univariada para identificar os fatores de risco relacionados à síndrome pós-cuidados intensivos. As escalas utilizadas para a avaliação das diferentes esferas foram Barthel, Pfeiffer, Hospital Anxiety and Depression Scale e Impact of Event Scale-6. As principais variáveis de interesse foram incidência da síndrome pós-cuidados intensivos de modo geral e por domínios. Os fatores de risco foram examinados em cada um dos domínios da saúde (saúde física, cognitiva e mental). Resultados: Participaram 87 pacientes. A Acute Physiology and Chronic Health Evaluation II média foi de 16,5. O número médio de dias na unidade de terapia intensiva foi 17. A incidência geral da síndrome pós-cuidados intensivos foi de 56,3% (n = 49; IC95% 45,8 - 66,2). A incidência da síndrome pós-cuidados intensivos em cada uma das esferas foi de 32,1% (física), 11,5% (cognitiva) e 36,6% (saúde mental). Conclusão: A incidência da síndrome pós-cuidados intensivos foi de 56,3%. A esfera da saúde mental foi a mais frequentemente envolvida. Os fatores de risco diferem, dependendo da área considerada.
ABSTRACT Objective: To determine the incidence of postintensive care syndrome in a cohort of critically ill patients admitted to the intensive care unit and to identify risk factors related to its development in the physical, cognitive and mental health areas. Methods: This was a prospective observational cohort study developed in the intensive care unit of a university hospital. Patients with intensive care unit stays equal to or longer than one week and the need for mechanical ventilation for more than 3 days, shock or delirium were included in the study. Demographic variables, reasons for admission, diagnoses, sedation, type of mechanical ventilation used, complications and length of stay were recorded. A univariate analysis was performed to identify risk factors related to postintensive care syndrome. The scales used for the assessment of the different spheres were Barthel, Pfeiffer, Hospital Anxiety and Depression Scale and Impact of Event Scale-6. The main variables of interest were postintensive care syndrome incidence overall and by domains. Risk factors were examined in each of the health domains (physical, cognitive and mental health). Results: Eighty-seven patients were included. The mean Acute Physiology and Chronic Health Evaluation II score was 16.5. The mean number of intensive care unit days was 17. The incidence of global postintensive care syndrome was 56.3% (n = 49, 95%CI 45.8 - 66.2%). The incidence of postintensive care syndrome in each of the spheres was 32.1% (physical), 11.5% (cognitive), and 36.6% (mental health). Conclusions: The incidence of postintensive care syndrome is 56.3%. The mental health sphere is the most frequently involved. The risk factors are different depending on the area considered.
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Introduction: Extracorporeal shock wave lithotripsy (ESWL) is an effective treatment for urolithiasis. Tamsulosin is capable of causing dilation and facilitating the migration of stones. The aim of this study is to evaluate the efficacy of adjuvant treatment with tamsulosin for improving the stone-free rate after a single session of ESWL in the treatment of kidney stones. Methods: This is a randomized, nonplacebo-controlled study with a sample of 60 adults with a single radiopaque kidney stone of 5-20 mm in diameter. After the ESWL session, the patients were divided into two groups. The control group received standard treatment for analgesia consisting of oral diclofenac (75 mg/12 h) as needed. The tamsulosin group received standard treatment for analgesia plus oral tamsulosin (0.4 mg/day) for eight weeks. In both groups, stone-free status was determined using a CT scan eight weeks after ESWL. The protocol of this study was registered with ClinicalTrials.gov, identifier: NCT04819828. Results: Only 57 patients completed the study (28 tamsulosin and 29 control). Overall, the average stone diameter was 11.42 ± 4.52 mm. The stone-free rate was 50.88% (29 of 57) overall, 53.57% (15 of 28) for the tamsulosin group, and 48.27% (14 of 29) for the control group (p = 0.680). The estimated relative risk in favor of the tamsulosin group to achieve a stone-free status was 1.11 (95% CI 0.67-1.9). The estimated number needed to treat to achieve a single patient with renal stone-free status after eight weeks of ESWL adjuvant treatment with tamsulosin was 19. Conclusion: Our findings suggest that tamsulosin as adjuvant treatment after a single ESWL session is well tolerated and safe, but it does not increase the stone-free rate in patients with a single radiopaque renal stone of 5-20 mm in diameter. Our results may support the use of tamsulosin with ESWL in the case of patients with a single radiopaque renal stone of 11-20 mm in diameter based on an apparent higher stone-free rate and a low rate of complications.
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Cálculos Renais , Litotripsia , Adulto , Terapia Combinada , Humanos , Cálculos Renais/tratamento farmacológico , Litotripsia/métodos , Dor/tratamento farmacológico , Sulfonamidas/uso terapêutico , Tansulosina/uso terapêutico , Resultado do TratamentoRESUMO
OBJETIVO: Determinar la tasa de recurrencia del cáncer de próstata localizado después de la prostatectomía radical según la clasificación D'Amico. MÉTODOS: Estudio de cohorte retrospectivo comparativo de 5 años. Se obtuvieron datos de registros clínicos de pacientes con cáncer de próstata localizado, que se sometieron a prostatectomía radical y se evaluó la tasa de recurrencia de la enfermedad. Se analizó con pruebas estadísticas descriptivas y comparativas. Una p < 0.05 se consideró significativo. RESULTADOS: Se analizó 108 pacientes, la edad promedio 65.3 años. Acerca de la clasificación de riesgo de D'Amico, 33.33% de bajo riesgo, 55.56% riesgo intermedio y 11.11% alto riesgo. La tasa de recurrencia de APE fue 14,81%. Los pacientes de bajo riesgo tuvieron recurrencia del 13.89%, riesgo intermedio 18.33% y alto riesgo no tuvieron recurrencia. Sobre piezas quirúrgicas, el 25.93% presentaron características adversas. La escala de Gleason postoperatoria muestra un aumento de 44.44% en bajo riesgo, 26.67% en riesgo intermedio y 41.67% en alto riesgo. CONCLUSIONES: La prostatectomía radical ofrece un control adecuado del cáncer de próstata localizado. La tasa de recurrencia del APE fue menor que otros informes internacionales. Asimismo, la recurrencia bioquímica del riesgo bajo, intermedio y alto fue similar a la tendencia global. OBJECTIVE: The objective of the study was to determine the recurrence rate of localized prostate cancer after radical prostatectomy according to the D'Amico classification. METHODS: This was a observational and 5-year comparative retrospective cohort study. Data were obtained from clinical records of patients with localized prostate cancer who underwent radical prostatectomy and the recurrence rate of the disease was evaluated. It was analyzed with descriptive and comparative statistical tests, p<0.05 was considered significant. RESULTS: One hundred and eight patients were analyzed, and the average age was 65.3 years. About D'Amico's risk classification, 33.33% low risk, 55.56% intermediate risk, and 11.11% high risk. The prostate-specific antigen (PSA) recurrence rate was 14.81%. Low-risk patients had recurrence of 13.89%, intermediate risk 18.33%, and high risk had no recurrence. Regarding surgical pieces, 25.93% presented adverse characteristics. The post-operative Gleason scale shows an increase of 44.44% in low risk, 26.67% in intermediate risk, and 41.67% in high risk. CONCLUSIONS: Radical prostatectomy offers adequate control of localized prostate cancer. The PSA recurrence rate was lower than other international reports. Likewise, the biochemical recurrence of low, intermediate, and high risk was similar to the global trend.
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Recidiva Local de Neoplasia , Neoplasias da Próstata , Idoso , Humanos , Masculino , Recidiva Local de Neoplasia/epidemiologia , Prostatectomia , Neoplasias da Próstata/epidemiologia , Neoplasias da Próstata/cirurgia , Estudos Retrospectivos , Centros de Atenção TerciáriaRESUMO
Abstract Introduction: Priapism is rare in dialysis patients. It is associated with several risk factors inherent to therapy and kidney disease. This condition has been reported in severe COVID-19 cases, probably caused by coagulopathy secondary to the infection. However, it has not been reported in patients with mild COVID-19. Case presentation: A 65-year-old patient on hemodialysis and with mild COVID-19 presented with a 30-hour painful penile erection. Physical examination revealed an erection, but no other significant findings were observed. Based on the clinical history, physical examination and laboratory test results, the patient was diagnosed with ischemic priapism. Corpora cavernosa drainage was performed and two injections of epinephrine (each with a dose of 2mL of epinephrine solution 1/100 000) were administered, achieving complete resolution of the symptoms. Conclusions: At the time of writing this case report, there is no information available on cases of priapism in patients with mild manifestations of COVID-19, nor is it clear how the risk of thrombosis should be assessed in this group of patients. From a pathophysiological point of view, factors related to dialysis and kidney disease could have predisposed this patient to priapism, although the role of SARS-CoV-2 infection is uncertain. Therefore, further studies are required to confirm or rule out the association between COVID-19 and priapism in dialysis patients.
Resumen Introducción. El priapismo es una condición infrecuente en pacientes en diálisis que se puede presentar por factores inherentes a esta terapia y a la enfermedad renal. Por otra parte, es una entidad que se ha reportado en pacientes con síntomas severos de COVID-19 y se ha asociado a coagulopatía secundaria a la infección, pero de la que no hay registro en casos leves de esta enfermedad. Presentación de caso. Paciente masculino de 65 años en hemodiálisis y con infección por SARS-CoV-2 con síntomas leves, quien consultó al servicio de urgencias de un hospital de cuarto nivel por erección peneana dolorosa de 30 horas de evolución. Al examen físico se evidenció la erección, sin otros hallazgos relevantes. Con base en la historia clínica, el examen físico y los resultados de laboratorio, se diagnosticó priapismo isquémico y se realizó drenaje de senos cavernosos y aplicación de dos inyecciones de epinefrina (cada una con una dosis de 2mL de solución de epinefrina 1/100 000), lográndose resolución completa de la condición. Conclusiones. Hasta el momento de la elaboración del presente reporte de caso no hay información disponible de casos de priapismo en pacientes con manifestaciones leves de COVID-19, y tampoco hay claridad de cómo se debe evaluar el riesgo de trombosis en este grupo de pacientes. Desde el punto de vista fisiopatológico, factores relacionados con la diálisis y la enfermedad renal pudieron predisponer a este paciente al priapismo, aunque no es claro el rol de la infección por SARS-CoV-2. Por tanto, se requieren estudios que permitan confirmar o descartar la asociación entre COVID-19 y priapismo en pacientes en diálisis.
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The authors give their point of view to the comments received on the article "The ENARM and the schools and faculties of medicine. An analysis that nobody will like", published in 2017, stating that, in their opinion, the important thing is to contribute to improve the fate of the graduates of the different medical schools.
Los autores otorgan su punto de vista a los comentarios recibidos sobre el artículo «El ENARM y las escuelas y facultades de medicina. Un análisis que no le va a gustar a nadie¼, el cual publicaron en 2017, manifestando que, en su opinión, lo importante es contribuir a mejorar el destino de los egresados de las diferentes facultades de medicina.
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Medicina , Faculdades de Medicina , HumanosRESUMO
In Mexico, the career of Doctor of Medicine has been considered as a prerequisite stage to access the specialization. Of course the majority of medical graduates aspire to undertake postgraduate courses in the different institutions that have a university program. The Examen Nacional de Aspirantes a Residencias Médicas (ENARM) (National Evaluation for Medical Residency Applicants) has become for the supporters a gap between the possibility of practicing the profession in a decent way and with a regular remuneration or exercising it in very limited conditions and with low economic income or even without exercising it. For educational institutions, the ENARM and the percentages of selection of their graduates are indicators of efficiency and a source of prestige and even of propaganda among the aspirants to study medicine. In this study, we carried out an analysis of the results of the ENARM in the last 15 years. For this we refer to the reports of the Postgraduate and Continuing Education Committee of the CIFRHS of the Directorate of Health Education of the General Directorate of Quality and Health Education Of the Undersecretariat of Innovation and Quality of the Ministry of Health, from the examination carried out in 2001 to the one carried out in 2016.
En México, la carrera de médico cirujano se ha considerado como una fase propedéutica para acceder a la especialización. Desde luego, la mayoría de los egresados de la carrera de medicina aspiran a realizar cursos de posgrado en las diferentes instituciones que tienen un programa universitario. El Examen Nacional de Aspirantes a Residencias Médicas (ENARM) se ha convertido para los sustentantes en un parteaguas entre la posibilidad de ejercer la profesión de una manera digna y con una retribución en promedio buena o ejercerla en condiciones muy limitadas y con ingresos económicos bajos o incluso no ejercerla. Para las instituciones educativas el ENARM y los porcentajes de selección de sus egresados son indicadores de eficiencia y motivo de prestigio e incluso de propaganda entre los aspirantes a estudiar medicina. En el presente estudio, realizamos un análisis de los resultados del ENARM en los últimos 15 años. Para ello consultamos los informes del Comité de Posgrado y Educación Continua de la Comisión Interinstitucional para la Formación de Recursos Humanos para la Salud (CIFRHS) de la Dirección de Educación en Salud de la Dirección General de Calidad y Educación en Salud de la Subsecretaría de Innovación y Calidad de la Secretaría de Salud, a partir del examen realizado en el año 2001 al realizado en 2016.
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Educação de Pós-Graduação em Medicina , Internato e Residência , Critérios de Admissão Escolar/estatística & dados numéricos , Faculdades de Medicina , Especialização , Educação de Pós-Graduação em Medicina/normas , Educação de Pós-Graduação em Medicina/estatística & dados numéricos , Avaliação Educacional/normas , Avaliação Educacional/estatística & dados numéricos , Humanos , Internato e Residência/normas , Internato e Residência/estatística & dados numéricos , México , Faculdades de Medicina/normas , Faculdades de Medicina/estatística & dados numéricosRESUMO
BACKGROUND: The medical alert system (MAS) was created for the timely handling of clinical decompensations, experienced by patients hospitalized at the Medical Surgical Service (MSS) in a private clinic. It is activated by the nurse when hemodynamic, respiratory, neurological, infectious or metabolic alterations appear, when a patient falls or complains of pain. A physician assesses the patient and decides further therapy. AIM: To analyze the clinical and demographic characteristics of patients who activated or not the MAS and develop a score to identify patients who will potentially activate MAS. MATERIAL AND METHODS: Data from 13,933 patients discharged from the clinic in a period of one year was analyzed. RESULTS: MAS was activated by 472 patients (3.4%). Twenty two of these patients died during hospital stay compared to 68 patients who did not activate the alert (0.5%, p < 0.01). The predictive score developed considered age, diagnosis (based on the tenth international classification of diseases) and whether the patient was medical or surgical. The score ranges from 0 to 9 and a cutoff ≥ 6 provides a sensitivity and specificity of 37 and 81% respectively and a positive likelihood ratio (LR+) of 1.9 to predict the activation of MAS. The same cutoff value predicts death with a sensitivity and specificity of 80% and a negative predictive value of 99.8%. CONCLUSIONS: This score may be useful to identify hospitalized patients who may have complications during their hospital stay.
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Sistemas de Apoio a Decisões Clínicas , Serviço Hospitalar de Emergência/estatística & dados numéricos , Triagem/normas , Idoso , Chile , Feminino , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Prognóstico , Fatores de Risco , Sensibilidade e EspecificidadeRESUMO
Background: The medical alert system (MAS) was created for the timely handling of clinical decompensations, experienced by patients hospitalized at the Medical Surgical Service (MSS) in a private clinic. It is activated by the nurse when hemodynamic, respiratory, neurological, infectious or metabolic alterations appear, when a patient falls or complains of pain. A physician assesses the patient and decides further therapy. Aim: To analyze the clinical and demographic characteristics of patients who activated or not the MAS and develop a score to identify patients who will potentially activate MAS. Material and Methods: Data from 13,933 patients discharged from the clinic in a period of one year was analyzed. Results: MAS was activated by 472 patients (3.4%). Twenty two of these patients died during hospital stay compared to 68 patients who did not activate the alert (0.5%, p < 0.01). The predictive score developed considered age, diagnosis (based on the tenth international classification of diseases) and whether the patient was medical or surgical. The score ranges from 0 to 9 and a cutoff ≥ 6 provides a sensitivity and specificity of 37 and 81% respectively and a positive likelihood ratio (LR+) of 1.9 to predict the activation of MAS. The same cutoff value predicts death with a sensitivity and specificity of 80% and a negative predictive value of 99.8%. Conclusions: This score may be useful to identify hospitalized patients who may have complications during their hospital stay.
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Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Triagem/normas , Sistemas de Apoio a Decisões Clínicas , Serviço Hospitalar de Emergência/estatística & dados numéricos , Prognóstico , Chile , Valor Preditivo dos Testes , Fatores de Risco , Sensibilidade e Especificidade , Tempo de InternaçãoRESUMO
For health institutions, knowing the fate of human resources within their classrooms is an extremely complicated task. Within the Instituto Mexicano del Seguro Social, where most specialists are trained in our country, with a clear orientation towards the pursuit of excellence and satisfaction of their needs human resources for health in Mexico is provided, hence the need to identify the professional profile and career destination of its graduates, which will be useful in the training of human resources for health.
Para las instituciones de salud, conocer el destino de los recursos humanos que se forman dentro de sus aulas es una tarea complicada. Al interior del IMSS se imparte la mayoría de los cursos de formación de especialistas en México, con una orientación clara hacía la búsqueda de la excelencia y la satisfacción de sus necesidades de recursos humanos para la salud, de ahí la necesidad de identificar el perfil profesional y el destino de sus egresados, lo que resultará de utilidad en la formación de recursos humanos para la salud.
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Escolha da Profissão , Medicina Interna , Médicos/provisão & distribuição , Academias e Institutos , Educação de Pós-Graduação em Medicina , Humanos , Medicina Interna/educação , Medicina Interna/tendências , México , Médicos/tendências , Previdência Social , Recursos HumanosRESUMO
The physician-patient relationship has been modified with the participation of other professionals that work on health services, the family and the community; as well as by scientific and technical developmental and the empowering of the citizens. The objective of the medical arbitration is to assure the patient general rights and to the professional of health. The model utilized for arbitration in our country is a reconciliation kind and the mediator quality is a warranty for the conciliation, the recommendation or the emission of an opinion judgment.
Assuntos
Negociação , Relações Médico-Paciente , Humanos , México , Direitos do Paciente , SociologiaRESUMO
Primary esophageal tuberculosis is virtually non-existent and there are few cases described of secondary esophageal tuberculosis. Esophageal tuberculosis should be suspected in patients with dysphagia, positive test results for tuberculin, active pulmonary disease or mediastinal adenopathies. Endoscopic or x-ray images could be indistinguishable from esophageal carcinomas, hence a diagnosis can prevent wrong treatments. Confirming the diagnosis requires isolation of tuberculosis bacillus. Treatment for a patient with esophageal tuberculosis is standard therapy. Key words: Tuberculosis, esophagus.
Assuntos
Doenças do Esôfago/diagnóstico , Tuberculose Gastrointestinal/diagnóstico , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
INTRODUCTION: Vasoconstriction is a major pathophysiologic finding in preeclampsia due to hyperactivity of the sympathetic nervous system and a consequent increase in concentration of plasmatic catecholamine. Thus, vasodilatation produced by secondary sympathetic block to lumbar epidural blockade favors control of high blood pressure in patients with severe preeclampsia. OBJECTIVE: Our objective was to evaluate whether lumbar epidural blockade with bupivacaine 0.25% decreases high blood pressure of patients with severe preeclampsia within a lapse of 6 h in comparison with customary antihypertensive treatment. MATERIAL AND METHODS: An open, randomized, controlled trial was carried out in 24 pregnant patients with 30 weeks of gestational age or more and diagnosis of severe preeclampsia who entered the Intensive Care Uni of the IMEIM Hospital of Gynecology and Obstetrics for hemodynamic stabilization and resolution of pregnancy. Group 1 (n = 12) was managed with customary antihypertensive treatment and group 2 (n = 12), with lumbar epidural blockade and bupivacaine 0.25%: 10 mg in bolus and 5 mg/h continuous epidural infusion. Patients were monitored non-invasively and with continuous clinical monitoring with MAP, SAP, and DAP during 6 h. Statistical analysis employed consisted of ANOVA measurement repeats. RESULTS: In MAP and SAP, there were no significant differences between the two groups; DAP in first and second h of treatment had significant differences between the two groups (p value of < or = 0.05). CONCLUSIONS: Lumbar epidural blockade with bupivacaine 0.25% can be used as a therapeutic alternative in high blood pressure control in patients with severe preeclampsia during the the first 6 h of hemodynamic stabilization.
Assuntos
Anestésicos Locais/administração & dosagem , Bupivacaína/administração & dosagem , Pré-Eclâmpsia/tratamento farmacológico , Adulto , Anestesia Epidural , Anestésicos Locais/efeitos adversos , Determinação da Pressão Arterial , Bupivacaína/efeitos adversos , Feminino , Humanos , Pré-Eclâmpsia/diagnóstico , Pré-Eclâmpsia/fisiopatologia , Gravidez , Estudos Prospectivos , Resultado do TratamentoRESUMO
Con el objetivo de determinar el nivel óptimo y económico del selenio orgánico en la alimentación y producción de la carpa común, se utilizaron 4 tratamientos: Testigo, dieta con 150, 200 y 250 mg de selenio orgánico (Selplex-50) por kilogramo de dieta base, en un diseño de bloques incompletos al azar con tres repeticiones en la zona de Corani K'asa. Los resultados obtenidos indican que la dieta 4 con un nivel de 250 mg de selenio orgánico posee el mejor índice de conversión alimenticia de 1.36, una ganancia de peso de 0.069 gr/día, una eficiencia alimenticia de 58
, una velocidad de crecimiento en longitud de 0.064 mm/día, un beneficio neto de 1313.654 $us/tn y la variable mortandad no es significativa, recomendándose este nivel. Sin embargo no se llegó a un nivel óptimo y es posible llegar a niveles deseados con concentraciones altas de selenio y se requiere de futuras investigaciones.