RESUMO
Zinc acexamate (ZAM) is an antiulcer agent with antisecretory and gastroprotective properties. The aim of this study was to evaluate endoscopically and morphometrically the efficacy of ZAM in the prophylaxis of gastroduodenal lesions induced by pyroxicam. Thirty nine patients from 30 to 70 years of age diagnosed with osteoarthritis without lesions in the upper digestive tract on basal endoscopy were studied. A randomized, double blind study was designed in which the patients received 20 mg/day of pyroxicam together with 300 mg/day of ZAM or placebo for 4 weeks. Clinical controls were undertaken on days 0, 14, 28 and endoscopic and histologic controls performed on days 0 and 28. The two groups were homogeneous regarding basal parameters. Endoscopic grading of the gastroduodenal lesions at the end of the study was lower in the group treated with ZAM (p < 0.001). Ulcers were found in only 2 patients (one antral and one duodenal) both of whom were in the placebo group (10.5%). Histologic scoring following treatment demonstrated higher values in the placebo group (p < 0.001) and scarce alterations with respect to base values in the group treated with ZAM. Morphometric quantification showed lower cell densities in both groups at the body level (p < 0.001). However, these did not vary in the antrum in the group treated with ZAM but increased in the placebo group (p < 0.001) as an expression of proliferative cell response to mucosal damage. At a single nightly dosis of 300 mg ZAM is effective in the prophylaxis of gastric and duodenal lesions induced by pyroxicam.
Assuntos
Aminocaproatos , Anti-Inflamatórios não Esteroides/efeitos adversos , Antiulcerosos/uso terapêutico , Mucosa Gástrica/efeitos dos fármacos , Osteoartrite/tratamento farmacológico , Piroxicam/efeitos adversos , Adulto , Idoso , Ácido Aminocaproico/uso terapêutico , Método Duplo-Cego , Feminino , Mucosa Gástrica/patologia , Gastroenteropatias/induzido quimicamente , Gastroenteropatias/patologia , Gastroenteropatias/prevenção & controle , Gastroscopia , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
BACKGROUND: The epidemiology of primary biliary cirrhosis (PBC) in Spain is still poorly known. In fact, remarkable differences between areas have been found. METHODS: The epidemiology of PBC was investigated in the South area of the city and the province of Granada from 1976 through 1989. Several clinical and epidemiological data were collected from 25 patients who met the criteria for PBC and the yearly incidence and prevalence were calculated. RESULTS: The ages of patients which PBC ranged from 31 to 74 years (mean age 50 +/- 10.5); 88% were females and 28% were diagnosed in the asymptomatic phase of the disease. The incidence for the study period was variable, with a maximum of 6.8 cases/million and an overall yearly incidence rate of 4.1 +/- 2.3 cases/million (7.1 +/- 4.3 cases/million for females). When the risk population was considered (people over 25 years) the respective values were 11.5 and 6.9 +/- 3.7 cases/million (12.1 +/- 7.2 cases/million for females). The prevalence showed a progressive increase, being 36.4 cases/million at the end of the study; for the "risk" population it was 61.5/million (100 cases/million for females). CONCLUSIONS: Incidence and prevalence of PBC in the area of study are within medium and medium-high values for Spain and Europe. As in other studies, personal environmental or social factors with epidemiological significance were not identified.
Assuntos
Cirrose Hepática Biliar/epidemiologia , Adulto , Fatores Etários , Idoso , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores Sexuais , Espanha/epidemiologiaRESUMO
Thirty one subjects are studied, 15 healthy (controls) and 16 presenting chronic alcoholic hepatopathy, in whom the existence of an autonomic insufficiency syndrome (AIS) was evaluated measuring the variations in heart rate while breathing (R index) and after standing up [O(B) index]. Vagal functioning was also studied when evaluating gastric emptying of digestible solids (VGS) and non digestible (VGSND). VGS after 45, 75 and 105 minutes in alcoholic patients was slower than in healthy controls (p less than 0.05) and in 50% of them it was slow after 105 minutes. VGSND was similar in both groups. R and O(B) indexes in alcoholic patients was smaller than in the control group (p less than 0.001), presenting 94% of them some index altered. An elevated percentage of patients suffering chronic alcoholic hepatopathy present a AIS which involves several organs, being R and O(B) indexes a better diagnostic method than VGS study.