RESUMO
Bioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-alpha-bisabolol (1) (ED(50) 155 microg/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, alpha-bisabolol (2) and alpha-terpineol (3) (ED(50) of 228 and 240 microg/g mouse[corrected], respectively).
Assuntos
Monoterpenos , Piperaceae/química , Extratos Vegetais/isolamento & purificação , Sesquiterpenos/isolamento & purificação , Células 3T3/efeitos dos fármacos , Animais , Cromatografia Líquida de Alta Pressão , Monoterpenos Cicloexânicos , Cicloexenos , Farneseno Álcool/farmacologia , Fibroblastos/efeitos dos fármacos , Espectroscopia de Ressonância Magnética , Camundongos , Estrutura Molecular , Sesquiterpenos Monocíclicos , Peru , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Plantas Medicinais/química , Sesquiterpenos/química , Sesquiterpenos/farmacologia , Estereoisomerismo , Relação Estrutura-Atividade , Terpenos/farmacologia , Testes de Toxicidade , CicatrizaçãoRESUMO
Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6.9 and 8.3 micrograms/mL respectively.
Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Plantas Medicinais/química , Triterpenos/isolamento & purificação , Animais , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/farmacologia , Cromatografia Líquida de Alta Pressão , Humanos , Espectroscopia de Ressonância Magnética , Camundongos , Ácido Oleanólico/análogos & derivados , Ácido Oleanólico/química , Ácido Oleanólico/isolamento & purificação , Ácido Oleanólico/farmacologia , Peru , Caules de Planta/química , Triterpenos/química , Triterpenos/farmacologia , Células Tumorais Cultivadas , Ácido UrsólicoRESUMO
The medicinal uses of local flora from the Callejón de Huaylas, Department of Ancash, northeastern Perú, are reported. This geographical area has an old tradition of herbal healing. A total of 33 species have been documented through interactions with village elders, traditional doctors and herbalists. Of the 33 medicinal plant species surveyed in the Callejón de Huaylas, six have not been previously reported, seven have received only minor phytochemical coverage in the literature, and the medicinal uses of seven other plants have not been corroborated with traditional medicinal reports from around the world. The traditional medicinal uses of six medicinal plants have been corroborated with previously published reports but their biological activities have yet to be confirmed in the laboratory. The medicinal uses of four other plants have been corroborated with previously published reports and their biological activities have been confirmed in the laboratory. The purported medicinal use of three plant species could not be confirmed in the laboratory.
Assuntos
Medicina Tradicional , Plantas Medicinais , Coleta de Dados , Etnobotânica , PeruRESUMO
Folk medicine practitioners in Perú employ plant preparations as wound-healing agents on superficial and internal wounds (gastric ulcers). The results of a scientific evaluation of the wound-healing activity of nine plants found in the Amazon jungle near Iquitos and in the Andes mountains is presented. The species studied were: Peperomia galioides, Mentzelia cordifolia, Mutisia acuminata, Himatanthus sucuuba, Spondias mombin, Eleutherine bulbosa, Muehlenbeckia tamnifolia, Anredera diffusa and Jatropha curcas. These plants have also been examined for their toxicological properties, their effect on blood pressure, smooth muscle and capillary permeability. Significant wound-healing activity was detected in Peperomia galioides, Anredera diffusa and Jatropha curcas. Extracts from Peperomia galioides and Anredera diffusa had no effect on cell proliferation and did not exhibit mutagenic activity.