RESUMO
The authors review their 20-year (1985-2004) experience with fine-needle aspiration biopsy (FNAB) in 829 children (all but 1 younger than 18 years), from whom 899 samples were obtained. All patients presented with clinical data suggesting malignancy. The procedure followed standard methods (22- to 24-gauge needle; mean of six alcohol-fixed and/or air-dried, H&E- or Giemsa-like-stained smears/procedure; leftover clots processed as a biopsy). Interpretation of cytologic smears was performed taking into consideration the clinical, laboratory, and imaging data. Smears diagnosed as positive for malignant cells were reported in 510 samples (56.7%) (463 patients); 1.89% of the smears were found inadequate for diagnosis. Positive for malignancy cases included 467 primary tumors, 52% of which were localized to the abdomen. NMYC status was determined on neuroblastoma samples by fluorescent in situ hybridization. Overall sensitivity of the procedure was 98% (500/510 FNAB); specificity was 92.6% (463/500 FNAB); positive predictive value was 1 and negative predictive value was 0.99. All FNABs diagnosed as benign tumors or inflammatory lesions correlated with histology and/or clinical outcome. FNAB proved to be highly cost-effective, avoiding a surgical biopsy. The procedure was found to be extremely helpful when deciding on preoperative chemotherapy.
Assuntos
Biópsia por Agulha Fina , Neoplasias/patologia , Neoplasias Abdominais/patologia , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Lactente , Masculino , Neoplasias/classificação , Reprodutibilidade dos Testes , Estudos Retrospectivos , Sensibilidade e Especificidade , Neoplasias Torácicas/patologiaRESUMO
El fibroadenoma es responsable del 75 por ciento de los tumores de mama en las mujeres entre 10 y 20 años de edad: la variedad Juvenil o Gigante corresponde al 2 por ciento de todos los fibroadenomas y al 7 por ciento de todas las lesiones de la mama en menores de 20 años. Presentamos el caso de una niña de 11 años con fibroadenoma juvenil gigante de mama de aparición en la premenarca y con 2 recurrencias, hacemos consideraciones sobre el caso y la entidad
Assuntos
Humanos , Feminino , Criança , Mama , Doença da Mama Fibrocística/classificação , FibroadenomaRESUMO
El fibroadenoma es responsable del 75 por ciento de los tumores de mama en las mujeres entre 10 y 20 años de edad: la variedad Juvenil o Gigante corresponde al 2 por ciento de todos los fibroadenomas y al 7 por ciento de todas las lesiones de la mama en menores de 20 años. Presentamos el caso de una niña de 11 años con fibroadenoma juvenil gigante de mama de aparición en la premenarca y con 2 recurrencias, hacemos consideraciones sobre el caso y la entidad