RESUMO
Antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis is an uncommon complication of the use of propylthiouracil. When it occurs, it affects multiple organs as any systemic vasculitis. We report three females and one male, aged 30, 40, 43 and 41 years respectively, that after a lapse of 12 to 28 months of propylthiouracil use, presented clinical signs of vasculitis. All had high titers of ANCA against myeloperoxidase. In three patients, a skin biopsy confirmed the diagnosis. The condition subsided when propylthiouracil was discontinued, but one female patient required the use of prednisone.
Assuntos
Anticorpos Anticitoplasma de Neutrófilos/efeitos dos fármacos , Antitireóideos/efeitos adversos , Propiltiouracila/efeitos adversos , Vasculite/induzido quimicamente , Adulto , Anticorpos Anticitoplasma de Neutrófilos/sangue , Antitireóideos/uso terapêutico , Biomarcadores/sangue , Biópsia , Feminino , Humanos , Hipertireoidismo/tratamento farmacológico , Masculino , Propiltiouracila/uso terapêutico , Vasculite/sangue , Vasculite/patologiaRESUMO
Antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis is an uncommon complication of the use of propylthiouracil. When it occurs, it affects multiple organs as any systemic vasculitis. We report three females and one male, aged 30, 40, 43 and 41 years respectively, that after a lapse of 12 to 28 months of propylthiouracil use, presented clinical signs of vasculitis. All had high titers of ANCA against myeloperoxidase. In three patients, a skin biopsy confirmed the diagnosis. The condition subsided when propylthiouracil was discontinued, but one female patient required the use of prednisone.