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1.
Int. braz. j. urol ; 43(6): 1160-1166, Nov.-Dec. 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-892919

RESUMO

ABSTRACT Objective: Testicular torsion (TT) refers to rotation of the testis and twisting of the spermatic cord. TT results in ischemia-reperfusion (I/R) injury involving increased oxidative stress, inflammation and apoptosis, and can even lead to infertility. The aim of this study was to investigate the effect of ozone therapy on testicular damage due to I/R injury in an experimental torsion model. Materials and Methods: 24 male Sprague-Dawley rats were divided into 3 groups; shamoperated, torsion/detorsion (T/D), and T/D+ozone. Ozone (1mg/kg) was injected intraperitoneally 120 minutes before detorsion and for the following 24h. Blood and tissue samples were collected at the end of 24h. Johnsen score, ischemia modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) levels were determined. Results: Levels of IMA, TOS, OSI, and histopathological scores increased in the serum/tissue of the rats in the experimental T/D group. Serum IMA, TOS, and OSI levels and tissue histopathological scores were lower in the rats treated with ozone compared with the T/D group. Conclusion: Our study results suggest that ozone therapy may exhibit beneficial effects on both biochemical and histopathological findings. Clinical trials are now necessary to confirm this.


Assuntos
Animais , Masculino , Ratos , Ozônio/uso terapêutico , Torção do Cordão Espermático/tratamento farmacológico , Traumatismo por Reperfusão/prevenção & controle , Estresse Oxidativo/efeitos dos fármacos , Testículo/irrigação sanguínea , Ratos Sprague-Dawley , Modelos Animais de Doenças
2.
Int Braz J Urol ; 43(6): 1160-1166, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28727368

RESUMO

OBJECTIVE: Testicular torsion (TT) refers to rotation of the testis and twisting of the spermatic cord. TT results in ischemia-reperfusion (I/R) injury involving increased oxidative stress, inflammation and apoptosis, and can even lead to infertility. The aim of this study was to investigate the effect of ozone therapy on testicular damage due to I/R injury in an experimental torsion model. MATERIALS AND METHODS: 24 male Sprague-Dawley rats were divided into 3 groups; sham-operated, torsion/detorsion (T/D), and T/D+ozone. Ozone (1mg/kg) was injected intraperi-toneally 120 minutes before detorsion and for the following 24h. Blood and tissue samples were collected at the end of 24h. Johnsen score, ischemia modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) levels were determined. RESULTS: Levels of IMA, TOS, OSI, and histopathological scores increased in the serum/tissue of the rats in the experimental T/D group. Serum IMA, TOS, and OSI levels and tissue histo-pathological scores were lower in the rats treated with ozone compared with the T/D group. CONCLUSION: Our study results suggest that ozone therapy may exhibit beneficial effects on both biochemical and histopathological findings. Clinical trials are now necessary to confirm this.


Assuntos
Estresse Oxidativo/efeitos dos fármacos , Ozônio/uso terapêutico , Traumatismo por Reperfusão/prevenção & controle , Torção do Cordão Espermático/tratamento farmacológico , Animais , Modelos Animais de Doenças , Masculino , Ratos , Ratos Sprague-Dawley , Testículo/irrigação sanguínea
3.
Rev. bras. anestesiol ; Rev. bras. anestesiol;65(5): 414-416, Sept.-Oct. 2015. graf
Artigo em Inglês | LILACS | ID: lil-763140

RESUMO

ABSTRACTJarcho Levin syndrome is a rare disorder. There are various vertebral and costal anomalies. Severe deformities and abnormal fusion of ribs and vertebrae cause respiratory insufficiency and pneumonia. We present anaesthesia in a patient with Jarcho Levin syndrome for vesicoureteral reflux.


RESUMOA síndrome de Jarcho-Levin é um distúrbio raro que apresenta várias anomalias vertebrais e costais. Deformidades graves e fusões anormais das costelas e vértebras causam insuficiência respiratória e pneumonia. Apresentamos um caso de anestesia em paciente com síndrome de Jarcho-Levin para refluxo vesicuretral.


Assuntos
Humanos , Feminino , Lactente , Hérnia Diafragmática/complicações , Anestesia/métodos , Refluxo Vesicoureteral/cirurgia , Anormalidades Múltiplas , Máscaras Laríngeas
4.
Rev Bras Anestesiol ; 65(5): 414-6, 2015.
Artigo em Português | MEDLINE | ID: mdl-26363698

RESUMO

Jarcho Levin syndrome is a rare disorder. There are various vertebral and costal anomalies. Severe deformities and abnormal fusion of ribs and vertebrae cause respiratory insufficiency and pneumonia. We present anaesthesia in a patient with Jarcho Levin syndrome for vesicoureteral reflux.

5.
Braz J Anesthesiol ; 65(5): 414-6, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26323743

RESUMO

Jarcho Levin syndrome is a rare disorder. There are various vertebral and costal anomalies. Severe deformities and abnormal fusion of ribs and vertebrae cause respiratory insufficiency and pneumonia. We present anaesthesia in a patient with Jarcho Levin syndrome for vesicoureteral reflux.


Assuntos
Anestesia/métodos , Hérnia Diafragmática/complicações , Anormalidades Múltiplas , Feminino , Humanos , Lactente , Máscaras Laríngeas , Refluxo Vesicoureteral/cirurgia
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