RESUMO
This cross-sectional study investigates metabolic bone disease and the relationship between age and bone mineral density (BMD) in males and females of a large, well-documented skeletal population of free-ranging rhesus monkeys (Macaca mulatta), from the Caribbean Primate Research Center Museum collection from Cayo Santiago, Puerto Rico. The sample consists of 254 individuals aged 1.0-20+ years. The data consist of measurements of bone mineral content and bone mineral density, obtained from dual-energy X-ray absorptiometry (DEXA), of the last lumbar vertebra from each monkey. The pattern of BMD differs between male and female rhesus macaques. Females exhibit an initial increase in BMD with age, with peak bone density occurring around age 9.5 years, and remaining constant until 17.2 years, after which there is a steady decline in BMD. Males acquire bone mass at a faster rate, and attain a higher peak BMD at an earlier age than do females, at around 7 years of age, and BMD remains relatively constant between ages 7-18.5 years. After age 7 there is no apparent effect of age on BMD in the males of this sample; males older than 18.5 years were excluded due to the presence of vertebral osteophytosis, which interferes with DEXA. The combined frequency of osteopenia and osteoporosis in this population is 12.4%. BMD values of monkeys with vertebral wedge fractures are generally higher than those of virtually all of the nonfractured osteopenic/osteoporotic individuals, thus supporting the view that BMD as measured by DEXA is a useful but imperfect predictor of fracture risk, and that low BMD may not always precede fractures in vertebral bones. Other factors such as bone quality (i.e., trabecular connectivity) should also be considered. The skeletal integrity of a vertebra may be compromised by the loss of key trabeculae, resulting in structural failure, but the spine may still show a BMD value within normal limits, or within the range of osteopenia.
Assuntos
Envelhecimento/metabolismo , Densidade Óssea , Doenças Ósseas Metabólicas/metabolismo , Osteoporose/metabolismo , Absorciometria de Fóton , Animais , Feminino , Macaca mulatta , Masculino , Porto Rico , Fatores SexuaisRESUMO
We describe the relative prevalence and pattern of distribution of osteoarthritis (OA) in the hands of elderly (> 15 years) rhesus macaques using clinical, radiographic, and skeletal examinations. In the clinical study the prevalence of nodes was 72% and 16% in the distal inter-phalangeal joints (DIPJ) and proximal inter-phalangeal joints (PIPJ), respectively, 31% of all monkeys had polyarticular nodes. Radiographic OA was present in 55%, 9.1%, and 0% of the DIPJs, PIPJs, and thumb base, respectively. Skeletal OA as defined by joint surface eburnation for the DIPJ, PIPJ, and thumb base were 16%, 8%, and 2%, respectively. A similar pattern of hand OA with humans is described except for the thumb base OA. This may be due to the relatively rudimentary manipulative role of the macaque thumb. The finding of polyarticular nodal OA raises the possibility of a common pathogenensis for IPJ OA amongst primates.
Assuntos
Mãos/diagnóstico por imagem , Osteoartrite/veterinária , Doenças dos Primatas , Animais , Artrografia , Osso e Ossos/diagnóstico por imagem , Osso e Ossos/patologia , Feminino , Macaca mulatta , Masculino , Osteoartrite/diagnóstico por imagem , Osteoartrite/patologia , Porto RicoRESUMO
The history of the Caribbean Primate Research Center Museum, including the Cayo Santiago Skeletal Collection, is briefly reviewed. Since 1971 skeletons of free-ranging rhesus monkeys from Cayo Santiago have been systematically collected for osteological research. Since 1981 the skeletons from the six species of New and Old World monkeys maintained at Sabana Seca have also been collected. The CPRC Museum was established the following year to house this comparative skeletal collection, as well as alcohol-stored tissue specimens and a library. The current status of the collection, including numbers and types of specimens, and use policies, are presented to give an overview of the research potential of the Museum for biological, anthropological, pathological, and biomedical research.
Assuntos
Osso e Ossos/anatomia & histologia , Cebidae/anatomia & histologia , Cercopithecidae/anatomia & histologia , Museus , Academias e Institutos , Animais , Porto RicoRESUMO
This report summarizes demographic data collected on the Cayo Santiago colony of rhesus monkeys from 1976-1983 and compares the results with those from 1959-1964 [8,9]. For males and nonpregnant/nonlactating, pregnant, and lactating females mean (+/- 1 SD), body weights, crown-rump lengths, and ponderal indices are tabulated for each age on a large (n = 586) single sampling of this free-ranging population of macaques.
Assuntos
Macaca mulatta , Macaca , Dinâmica Populacional , Reprodução , Estatísticas Vitais , Animais , Animais Selvagens , Antropometria , Peso Corporal , Feminino , Macaca/fisiologia , Macaca mulatta/anatomia & histologia , Macaca mulatta/fisiologia , Masculino , Crescimento Demográfico , Porto Rico , Estações do AnoRESUMO
Free-ranging patas monkeys (Erythrocebus patas) from El Guayacán island, Puerto Rico, were surveyed to establish values for the hemogram, serum biochemicals, calcium, and phosphorus. Results were tabulated for males and nonpregnant/nonlactating, pregnant, and lactating females. A summary of blood values from previous studies on captive patas monkeys was also tabulated for comparison.