Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
J Pediatr ; 167(1): 52-7.e1-3, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25863661

RESUMO

OBJECTIVE: To investigate the safety and short term outcome of high dose recombinant human erythropoietin (rhEpo) given shortly after birth and subsequently over the first 2 days for neuroprotection to very preterm infants. STUDY DESIGN: Randomized, double masked phase II trial. Preterm infants (gestational age 26 0/7-31 6/7 weeks) were given rhEpo (nt = 229; 3000 U/kg body weight) or NaCl 0.9% (nc = 214) intravenously at 3, 12-18, and 36-42 hours after birth. RESULTS: There were no relevant differences between the groups for short-term outcomes such as mortality, retinopathy of prematurity, intraventricular hemorrhage, sepsis, necrotizing enterocolitis, and bronchopulmonary dysplasia. At day 7-10, we found significantly higher hematocrit values, reticulocyte, and white blood cell counts, and a lower platelet count in the rhEpo group. CONCLUSIONS: Early high-dose rhEpo administration to very premature infants is safe and causes no excess in mortality or major adverse events. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00413946.


Assuntos
Deficiências do Desenvolvimento/prevenção & controle , Eritropoetina/administração & dosagem , Recém-Nascido Prematuro , Fármacos Neuroprotetores/administração & dosagem , Displasia Broncopulmonar/epidemiologia , Relação Dose-Resposta a Droga , Método Duplo-Cego , Enterocolite Necrosante/epidemiologia , Europa (Continente)/epidemiologia , Hematócrito , Humanos , Hipóxia-Isquemia Encefálica/epidemiologia , Recém-Nascido , Hemorragias Intracranianas/epidemiologia , Contagem de Leucócitos , Leucomalácia Periventricular/epidemiologia , Contagem de Plaquetas , Proteínas Recombinantes/administração & dosagem , Contagem de Reticulócitos , Retinopatia da Prematuridade/epidemiologia , Sepse/epidemiologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA