RESUMO
PURPOSE: To assess weight changes in rats fed diets with different ratios of omegas 3, 6 and 9 submitted to colonic carcinogenesis induced by Azoxymethane (AOM). METHODS: Sixty rats with three weeks of life were distributed into five groups of specific diets containing 12 animals each: GI- Standard diet without administration of AOM, GII- Standard diet with administration of AOM; GIII- Hyperlipidic diet with administration of AOM; GIV-Normolipidic diet with administration of AOM; GV- Hypolipidic diet with administration of AOM. The weight and food intake of each group were assessed four times in each week throughout the experiment until euthanasia at 36th week. RESULTS: GI and GII had no significant difference in weight. GI showed a significant increase when compared to GIII, GIV and GV. GII also showed a significant increase when compared to GIII, GIV and GV. When comparing intake of GI as compared to GII no significant difference was found, however such groups had higher intake than groups III, IV and V. There were found no difference in weight when comparing among rats with and without cancer within each groups: GII, GIII, GIV and GV. CONCLUSIONS: Diets rich in omega 3, 6 and 9 reduced food intake and weight. Rats with colorectal cancer had no decrease in weight as compared to those without this condition in the same group.
Assuntos
Peso Corporal/efeitos dos fármacos , Neoplasias do Colo/metabolismo , Ingestão de Alimentos/efeitos dos fármacos , Ácidos Graxos Insaturados/administração & dosagem , Alimentos Fortificados , Animais , Azoximetano , Carcinógenos , Neoplasias do Colo/induzido quimicamente , Ácidos Graxos Ômega-3/administração & dosagem , Ácidos Graxos Ômega-6/administração & dosagem , Injeções Intraperitoneais , Masculino , Ácidos Oleicos/administração & dosagem , Distribuição Aleatória , Ratos WistarRESUMO
Introdução: A fístula quilosa cervical (FQC) é uma complicação incomum na cirurgia de cabeça e pescoço, mas bem descrita na literatura, com uma incidência estimada de 1% a 2,5%. Objetivo: Apresentar uma nova modalidade terapêutica para tratamento de fistula quilosa cervical grave. Métodos: Relatamos uma nova alternativa de tratamento para fistula quilosa cervical grave, por embolização do ducto torácico. Esse método foi utilizado em um caso clínico de fístula quilosa grave, decorrente de cirurgia de tumor cervical benigno, onde não se obteve resolução com a reoperação, uso de fibrina e nutrição parenteral total com emprego concomitante de somatostatina. Posteriormente, foi submetido a uma abordagem de tratamento através de embolização retrógada do ducto torácico, empregando microcatéter com auxílio de equipamentos de hemodinâmica, obtendo-se absoluto sucesso. Conclusão: A embolização do ducto torácico através de acesso percutâneo tem sido modernamente descrito como uma alternativa eficiente no tratamento da fístula quilosa cervical. Utilizamos uma alternativa desse método através de cateterização retrógada do ducto torácico a partir da ferida cervical, obtendo-se imediato fechamento da fístula. Esse relato é o primeiro da literatura nacional empregando essa alternativa terapêutica, que deve ser considerada no tratamento da fístula quilosa cervical grave.
Introduction: Cervical chilous fistula (CCF) is a rare complication of head and neck surgery. However, it is well described in the literature. The incidence has been estimated to range from 1% to 2.5%. Objective: To present a new therapeutic modality for severe CCF. Methods: We report a new alternative treatment for severe cervical chylous fistula using embolization of the thoracic duct. This method was used in a case of a patient underwent resection of cervical lipoma in which no resolution was obtained with reoperation, use of fibrin, and total parenteral nutrition associated with administration of somatostatin. Subsequently it was subjected to an approach to treatment by retrograde cannulation and embolization of the thoracic duct, using microcatheter with hemodynamic equipment, resulting in absolute success. Conclusion: The percutaneous access of the thoracic duct for embolization has been described as a modern efficient alternative in the treatment of CCF. We used an alternative method by choosing a retrograde cannulation and embolization of the thoracic duct culminating in immediate closure of the fistula. This report is the first national literature using this alternative therapy, which should be considered in the treatment of severe cervical chylous fistula.