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OBJECTIVE: To evaluate the differences and similarities in clinical picture, laboratory findings and outcomes between children's with Kawasaki Disease (KD) versus multisystem inflammatory syndrome (MIS-C). METHODS: We conducted a retrospective, comparative study from children with Kawasaki Disease (KD) hospi-talized in Sinaloa Pediatric Hospital from January 1, 2004, to March 31, 2020, and patients with multisystem inflammatory syndrome (MIS-C) according with World Health Organization (WHO) case definition criteria be-tween May 1, 2020 and May 31, 2021. Demographic characteristics, epidemiological data, clinical features, laboratory findings, type of treatment and clinical outcomes were compared among both groups. RESULTS: Eighty-one patients were included (62 patients with KD and 19 with MIS-C). several clinical and lab-oratory differences were found among these two entities. Median age was lower in KD vs. MIS-C (25 vs 79 months). Those finding more frequent in KD were male gender (64.5 vs. 47.4%), Mucocutaneous features (93.5 vs. 63.2%): Oral changes (83.9 vs. 63.2%) and extremity changes (77.4 vs. 57.9%); complete form of KD was (75.8 vs. 47.4%), Coronary artery aneurysm (16.1 vs. 11.8%). Secondly, findings that were more frequent in MIS-C than KD were Gastrointestinal involvement (89.4 vs. 9.6%), shock (57.9 vs. 3.2%), neurological symp-toms (63.1 vs. 11.2%), kidney involvement (52.6 vs. 16.1%), heart disease in general (52.9% vs 29%): Myocardial dysfunction (23.5 vs. 11.3%) and pericardial effusion (17.6 vs. 2.9%). Lymphocyte count (2.07 + 2.03 vs. 4.28 + 3.01/mm3), platelet count (197.89 + 187.51 vs. 420.37 + 200.08/mm3); serum albumin (2.29 + 0.65 vs. 3.33 + 0.06g/dL), and CPR (21.4 + 11.23 vs. 14.26 + 12.37 mg/dL). KD vs. MIS-C types of Treatment: IVIG (96.8 vs. 94.7%), systemic steroids (4.82 vs. 94.7%), IVIG resistance (19.4 vs. 15.8). Finally, mortality in KD was 0% and 5.3% in MIS-C. CONCLUSIONS: Similarities were found in both groups such as fever, rash, and conjunctivitis. Nevertheless, signifi-cant differences such as severity of clinical presentation with multi-organ involvement and worst inflammato-ry response were found more frequently in MIS-C group than KD group, requiring more fluid replacement, use of inotropic agents and higher steroids dosages. Also, mortality rate was higher in patients with MIS-C thanpatients with KD. Similar results have been observed in other studies where both disorders were compared.
OBJECTIVO: Evaluar las diferencias y similitudes en el cuadro clínico, los hallazgos de laboratorio y desenlaces médicos de pacientes pediátricos con enfermedad de Kawasaki versus síndrome inflamatorio multisistémico. MÉTODOS: Estudio comparativo y retrospectivo, efectuado en niños con enfermedad de Kawasaki, atendidos en el Hospital Pediátrico de Sinaloa, entre el 1 de enero de 2004 al 31 de marzo de 2020, y pacientes con sín-drome inflamatorio multisistémico (según los criterios de la Organización Mundial de la Salud), del 1 de mayo de 2020 al 31 de mayo de 2021. Se evaluaron las características demográficas, epidemiológicos y clínicas, además de los hallazgos de laboratorio, tipo de tratamiento y desenlaces clínicos en ambos grupos. RESULTADOS: Se incluyeron 81 pacientes: 62 con enfermedad de Kawasaki y 19 con síndrome inflamatorio mul-tisistémico. Se encontraron varias diferencias clínicas y de laboratorio en ambas alteraciones. La mediana de edad fue menor en pacientes con enfermedad de Kawasaki versus síndrome inflamatorio multisistémico (25 vs 79 meses). La mayoría de los pacientes con enfermedad de Kawasaki fueron hombres (64.5 vs 47.4%), con características mucocutáneas (93.5 vs 63.2%): cambios orales (83.9 vs 63.2%) y cambios en las extremidades (77.4 vs 57.9%); la forma completa de enfermedad de Kawasaki fue 75.8 vs 47.4%, concomitante con aneuris-ma de la arteria coronaria (16.1 vs 11.8%). Los hallazgos más frecuentes en sujetos con síndrome inflamatorio multisistémico fueron: afectación gastrointestinal (89.4 vs 9.6 %), choque (57.9 vs 3.2%), síntomas neurológicos (63.1 vs 11.2%), afectación renal (52.6 vs 16.1%) y cardiopatías en general (52.9 vs 29%): disfunción miocárdica (23.5 vs 11.3%) y derrame pericárdico (17.6 vs 2.9%). La concentración media de linfocitos fue: 2.07 + 2.03 vs4.28 + 3.01/mm3), plaquetas (197.89 + 187.51 vs 420.37 + 200.08/mm3); albúmina sérica (2.29 + 0.65 vs 3.33 + 0.06 g/dL) y PCR (21.4 + 11.23 vs 14.26 + 12.37 mg/dL). Los tratamientos en enfermedad de Kawasaki vssíndrome inflamatorio multisistémico: IVIG (96.8 vs 94.7%), corticosteroides sistémicos (4.82 vs 94.7%), resis-tencia a IVIG (19.4 vs 15.8). La mortalidad fue de 0 vs 5.3%. CONCLUSIONES: Se encontraron similitudes en cuanto a síntomas en ambos grupos (fiebre, exantema y conjun-tivitis); no obstante, hubo diferencias significativas respecto de las manifestaciones clínicas, con afección multiorgánico y peor respuesta inflamatoria en pacientes con síndrome inflamatorio multisistémico, incluso mayor requerimiento de reposición de líquidos, administración de agentes inotrópicos, dosis más altas de corticosteroides, y elevada tasa de mortalidad. Estos resultados se han observado en otros estudios, donde se compararon ambos trastornos.
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AIMS: The purpose of this work was to obtain a hydrophobic sorbent material with potential applications in oil spill remediation. BACKGROUND: The accidents due to oil spills cause long-term ecological damage, especially in the aquatic environment. The cleaning of oil spills can be carried out by many methods and techniques, being absorbents the most attractive due to the possibility of recovery and complete elimination of the hydrocarbons in situ from the water surface. In recent years, interest in polymeric materials for oil spill remediation has increased due to its low cost, high stability, and recyclability. OBJECTIVE: The objective of this work was the development of sorbent materials based on polymer wastes, such as Polyethylene Terephthalate (PET), obtained from recycled bottles, and recycled Polyurethane (PU), for its application in the recovery of oil spills. METHODS: Sorbent materials were prepared from polymer wastes, using salt molds for the formation of porous materials with a composition of PU of 5, 10 and 15%, which were subsequently hydrophobized using carbon nanotubes or silica nanoparticles by dip-coating technique. RESULTS AND DISCUSSION: The obtained hydrophobic sorbent materials were characterized by Scanning Electron Microscopy (SEM) and Infrared Spectroscopy (FTIR). The resulting absorbent has shown capacity to separate oil from water; the best result was obtained by the sponge of PET-PU (10% PU) hydrophobized with a suspension with low multi-wall carbon nanotubes (MWCNTs) concentration, obtaining an absorption capacity of 2.01 g/g. CONCLUSION: Besides the standard sorption capacity, these cheap sorbent materials had interesting properties like low density, high hydrophobicity and buoyancy, which could be applied in other applications related to solving oil spills.
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O presente artigo pretende refletir sobre o processo de constituição subjetiva do bebê prematuro internado em UTI neonatal, seus impasses e possibilidades de superação da condição de organismo a sujeito, destacando as implicações do não reconhecimento primordial na prematuridade bem como a importância do outro no estabelecimento dos endereçamentos desenvolvidos entre bebê, mãe e equipe de saúde...
This article aims to reflect on the process of subjective constitution of preterm babies hospitalized in neonatal ICU, their impasses, and the possibilities of overcoming the condition of organism to subject, highlighting the implications of the primordial nonrecognition in prematurity, as well as the importance of the other in the establishment of the interactions developed among baby, mother, and medical staff...
Este artículo propone a reflexionar acerca del proceso de constitución subjetiva del bebé prematuro internado en la UCI neonatal, sus consecuencias y posibilidades de superación de la condición de organismo a sujeto, resaltando las consecuencias del no reconocimiento primordial acerca de la prematuridad, así como la importancia del "otro" en el establecimiento de los direccionamientos desarrollados entre bebé, madre y equipo médico...
Assuntos
Humanos , Feminino , Adulto , Unidades de Terapia Intensiva Neonatal , Recém-Nascido Prematuro/psicologia , Relações Mãe-Filho/psicologiaRESUMO
O presente artigo pretende refletir sobre o processo de constituição subjetiva do bebê prematuro internado em UTI neonatal, seus impasses e possibilidades de superação da condição de organismo a sujeito, destacando as implicações do não reconhecimento primordial na prematuridade bem como a importância do outro no estabelecimento dos endereçamentos desenvolvidos entre bebê, mãe e equipe de saúde. (AU)
This article aims to reflect on the process of subjective constitution of preterm babies hospitalized in neonatal ICU, their impasses, and the possibilities of overcoming the condition of organism to subject, highlighting the implications of the primordial nonrecognition in prematurity, as well as the importance of the other in the establishment of the interactions developed among baby, mother, and medical staff. (AU)
Este artículo propone a reflexionar acerca del proceso de constitución subjetiva del bebé prematuro internado en la UCI neonatal, sus consecuencias y posibilidades de superación de la condición de organismo a sujeto, resaltando las consecuencias del no reconocimiento primordial acerca de la prematuridad, así como la importancia del "otro" en el establecimiento de los direccionamientos desarrollados entre bebé, madre y equipo médico. (AU)
Assuntos
Humanos , Feminino , Adulto , Recém-Nascido Prematuro/psicologia , Unidades de Terapia Intensiva Neonatal , Relações Mãe-Filho/psicologiaRESUMO
Objetivou-se identificar os fatores de risco no trabalho e os problemas de saúde percebidos pelos trabalhadores de enfermagem de um instituto de doenças tropicais. Trata-se de um estudo descritivo-exploratório, com abordagem quantitativa. A amostra era composta por 99 trabalhadores de enfermagem, no ano de 2011. Para a coleta de dados aplicou-se um questionário criado por Boix e Vogel em 1997. Os dados foram analisados através do programaSPSS® versão 17.0. O estudo foi apreciado pelo Comitê de Ética em Pesquisa da Universidade Federal do Piauí. Dentre os fatores de riscos apontados, destacaram-se os biológicos, seguidos pelos riscos ergonômicos, físicos e psicossociais. Em relação aos problemas de saúde, relacionados ao trabalho, evidenciaram-se como mais frequentes: varizes, problemas osteomusculares, transtornos do sono e problemas psicossociais, como estresse edepressão.Verifica-se, então, que o ambiente de trabalho possui fatores de risco que interferem na saúde do trabalhador de enfermagem.
This study aimed to identify risk factors at work and health problems perceived by nursing staff of an institute for tropical diseases. This is a descriptive exploratory study with a quantitative approach. The sample consisted of 99 nursing staff, in the year 2011. A questionnaire created by Boix and Vogel in 1997 was applied for data collection. Data were analyzed using SPSS® version 17.0. The study was appreciated by the Ethics Committee of the Universidade Federal do Piauí. Among the risk factors pointed out, biologics aspects, followed by ergonomic, physical and psychosocial hazards, were highlighted. In relation to health problems related to work, the most frequent ones were: varicose veins, musculoskeletal problems, sleep disorders and psychosocial problems, such as stress and depression. So, then the work environment has risk factors that interfere in occupational health nursing.
Este estudio tuvo como objetivo identificar los factores de riesgo en el trabajo y problemas de salud percibidos por el personal de enfermería de un instituto para enfermedades tropicales. Se trata de un estudio exploratorio descriptivo, con abordaje cuantitativo. La muestra estaba compuesta por 99 trabajadores de enfermería en 2011. Para recopilar los datos se aplicó un cuestionario creado por Boix y Vogel en 1997. Los datos fueron analizados utilizando el SPSS® versión 17.0. El estudio fue revisado por el Comité de Ética en Investigación de la Universidad Federal de Piauí. Entre los factores de riesgo mencionados se destacaron los aspectos biológicos, seguido de los riesgos ergonómicos, físicos y psicosociales. En relación con los problemas de salud relacionados con el trabajo, se mostraron como frecuentes: las venas varicosas, problemas músculo-esqueléticos, trastornos del sueño y los problemas psicosociales como el estrés y la depresión. El ambiente de trabajo tiene factores de riesgo que afectan la salud de los trabajadores de enfermería.
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Humanos , Masculino , Feminino , Medicina Tropical , Condições de Trabalho , Riscos Ocupacionais , Saúde Ocupacional , Enfermeiras e Enfermeiros , Condições de Trabalho , Inquéritos e Questionários , Hospitais PúblicosRESUMO
Alcohol abuse constitutes a major cohort among HIV-infected individuals. The precise effect of alcohol addiction on HIV pathogenesis remains inconclusive, however. This study was designed to determine the effect of alcohol dependence on virus replication and CD4 profiles in simian immunodeficiency virus/simian-HIV-infected rhesus macaques. A group of 3 male Indian rhesus macaques was adapted to a self-drinking model of alcohol consumption, whereas another group of 3 macaques was provided a Nutrasweet solution. After 7 weeks of alcohol consumption, the alcohol-dependent animals along with controls were intravenously inoculated with a mixture of SHIV(KU), SHIV(89.6)P, and SIV/17E-Fr. These animals were followed for a period of 24 weeks for complete blood cell counts, CD4 cell profiles, and viral loads in the blood and cerebral compartments. The alcohol and control groups showed comparable peak viral loads in the blood. The plasma viral load in the alcohol group was 31- to 85-fold higher than that in the control group at weeks 18 through 24 after infection, however. The pattern of cerebrospinal fluid viral replication was also comparable during the acute phase; however, the virus continued to replicate in the brain of alcohol-dependent animals, whereas it became undetectable in the controls. The extent of CD4 cell loss in the alcohol group was significantly higher than that in the control animals at week 1 after infection.
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Alcoolismo/fisiopatologia , Retrovirus dos Símios/fisiologia , Síndrome de Imunodeficiência Adquirida dos Símios/fisiopatologia , Vírus da Imunodeficiência Símia/fisiologia , Replicação Viral , Alcoolismo/complicações , Alcoolismo/virologia , Animais , Relação CD4-CD8 , Linfócitos T CD4-Positivos/fisiologia , Linfócitos T CD8-Positivos/fisiologia , Macaca mulatta , Masculino , RNA Viral/sangue , RNA Viral/líquido cefalorraquidiano , Síndrome de Imunodeficiência Adquirida dos Símios/complicações , Síndrome de Imunodeficiência Adquirida dos Símios/virologia , Fatores de Tempo , Carga ViralRESUMO
Six rhesus macaques were adapted to morphine dependence by injecting three doses of morphine (5 mg/kg of body weight) for a total of 20 weeks. These animals along with six control macaques were infected intravenously with mixture of simian-human immunodeficiency virus KU-1B (SHIV(KU-1B)), SHIV(89.6P), and simian immunodeficiency virus 17E-Fr. Levels of circulating CD4(+) T cells and viral loads in the plasma and the cerebrospinal fluid were monitored in these macaques for a period of 12 weeks. Both morphine and control groups showed precipitous loss of CD4(+) T cells. However this loss was more prominent in the morphine group at week 2 (P = 0.04). Again both morphine and control groups showed comparable peak plasma viral load at week 2, but the viral set points were higher in the morphine group than that in the control group. Likewise, the extent of virus replication in the cerebral compartment was more pronounced in the morphine group. These results provide a definitive evidence for a positive correlation between morphine and levels of viral replication.