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The present database contains brain activity of subjective tinnitus sufferers at identifying their sound tinnitus. The main objective of this database is to provide spontaneous Electroencephalographic (EEG) activity at rest, and evoked EEG activity when tinnitus sufferers attempt to identify their sound tinnitus among 54 tinnitus sound examples. For the database, 37 volunteers were recruited: 15 ones without tinnitus (Control Group - CG), and 22 ones with tinnitus (Tinnitus Group - TG). For EEG recording, 30 channels were used to record two conditions: 1) basal condition, where the volunteer remained in a state of rest with the open eyes for two minutes; and 2) active condition, where the volunteer must have identified his/her sound stimulus by pressing a key. For the active condition, a sound-tinnitus library was generated in accordance with the most typical acoustic properties of tinnitus. The library consisted in ten pure tones (250 Hz, 500 Hz, 1 kHz, 2 kHz, 3 kHz, 3.5 kHz, 4 kHz, 6 kHz, 8 kHz, 10 kHz), a White Noise (WN), a Narrow Band noise-High frequencies (NBH, 4 kHz-10 kHz), a Narrow Band noise-Medium frequencies (NBM,1 kHz-4 kHz), a Narrow-Band noise Low frequencies (NBL, 250 Hz-1 kHz), ten pure tones combined with WN, ten pure tones superimposed with NBH, ten tones with NBM and ten pure tones combined with NBL. In total, 54 sound-tinnitus were applied for both groups. In the case of CG, volunteers must have identified a sound at 3.5 kHz. In addition to EEG information, a csv-file with audiometric and psychoacoustic information of volunteers is provided. For TG, this information refers to: 1) hearing level, 2) type of tinnitus, 3) tinnitus frequency, 4) tinnitus perception, 5) Hospital Anxiety and Depression Scale (HADS) and 6) Tinnitus Functional Index (TFI). For CG, the information refers to: 1) hearing level, and 2) HADS.
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Background: The NutrIMSS program is granted to populations with chronic conditions to improve basic health indicators and its effectiveness in this population is unknown. Objective: To analyze the change in the basic health indicators of patients who attended the NutrIMSS Program, at the UMF No. 2 of the IMSS in Mexico City, during the period 2018 to 2019. Material and methods: From 105 files of IMSS beneficiaries, a retrospective cohort study was carried out considering two measurements, before and after the NutrIMSS program. To evaluate the average change over time of health indicators, GEE models (Generalized Estimation Equations) and multiple linear regression models were used. Statistical analysis was used using the statistical program StataCorp 2015. Results: Patients who attended the Program showed changes between the beginning and end of the period with an average of three months of follow-up. They presented a decrease in the following health indicators: body weight of 1 kg, body mass index: 0.8 kg/m2, glucose of 13 mg/dL, triglycerides of 57 mg/dL and cholesterol of 17 mg/dL (p < 0.005 in all cases). There was no difference in the level of blood pressure. Conclusions: The NutrIMSS program influenced the improvement of the health indicators of the population of the program and is an ally to improve the health of the IMSS beneficiary population.
Introducción: el programa NutrIMSS se otorga a población con padecimientos crónicos para mejorar los indicadores básicos de salud; sin embargo, se desconoce su efectividad en esta población. Objetivo: analizar el cambio en los indicadores básicos de salud de pacientes que acudieron al programa NutrIMSS, en la UMF No. 2 del Instituto Mexicano del Seguro Social (IMSS) en la Ciudad de México, durante el periodo 2018 a 2019. Material y métodos: a partir de 105 expedientes de derechohabientes del IMSS se realizó un estudio de cohorte retrospectiva, considerando dos mediciones, antes y después del programa NutrIMSS. Para evaluar el cambio promedio en el tiempo de los indicadores de salud se utilizaron modelos GEE (Ecuaciones de Estimación Generalizadas) y modelos de regresión lineal múltiple. Para el análisis estadístico se utilizó el programa estadístico StataCorp 2015. Resultados: los pacientes que acudieron a NutrIMSS mostraron cambios entre el inicio y el fin del periodo, con un promedio de seguimiento de tres meses. Presentaron una disminución en los siguientes indicadores de salud: peso corporal de 1 kg, índice de masa corporal: 0.8 kg/m2, glucosa de 13 mg/dL, triglicéridos de 57 mg/dL y colesterol de 17 mg/dL (p < 0.005, en todos los casos). No se presentó diferencia en el nivel de la tensión arterial. Conclusiones: el programa NutrIMSS influyó para mejorar los indicadores de salud de la población del programa y es un aliado en la mejora de la salud de la población derechohabiente del IMSS.
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Colesterol , Diabetes Mellitus Tipo 2 , Humanos , Estudos Retrospectivos , Triglicerídeos , Índice de Massa Corporal , MéxicoRESUMO
Introduction: So far, Auditory Event-Related Potential (AERP) features have been used to characterize neural activity of patients with tinnitus. However, these EEG patterns could be used to evaluate tinnitus evolution as well. The aim of the present study is to propose a methodology based on AERPs to evaluate the effectiveness of four acoustic therapies for tinnitus treatment. Methods: The acoustic therapies were: (1) Tinnitus Retraining Therapy (TRT), (2) Auditory Discrimination Therapy (ADT), (3) Therapy for Enriched Acoustic Environment (TEAE), and (4) Binaural Beats Therapy (BBT). In addition, relaxing music was included as a placebo for both: tinnitus sufferers and healthy individuals. To meet this aim, 103 participants were recruited, 53% were females and 47% were males. All the participants were treated for 8 weeks with one of these five sounds, which were moreover tuned in accordance with the acoustic features of their tinnitus (if applied) and hearing loss. They were electroencephalographically monitored before and after their acoustic therapy, and wherefrom AERPs were estimated. The sound effect of acoustic therapies was evaluated by examining the area under the curve of those AERPs. Two parameters were obtained: (1) amplitude and (2) topographical distribution. Results: The findings of the investigation showed that after an 8-week treatment, TRT and ADT, respectively achieved significant neurophysiological changes over somatosensory and occipital regions. On one hand, TRT increased the tinnitus perception. On the other hand, ADT redirected the tinnitus attention, what in turn diminished the tinnitus perception. Tinnitus handicapped inventory outcomes verified these neurophysiological findings, revealing that 31% of patients in each group reported that TRT increased tinnitus perception, but ADT diminished it. Discussion: Tinnitus has been identified as a multifactorial condition highly associated with hearing loss, age, sex, marital status, education, and even, employment. However, no conclusive evidence has been found yet. In this study, a significant (but low) correlation was found between tinnitus intensity and right ear hearing loss, left ear hearing loss, heart rate, area under the curve of AERPs, and acoustic therapy. This study raises the possibility to assign acoustic therapies by neurophysiological response of patient.
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Bone formation is a dynamic process directed by osteoblast activity. The transition from the proliferation to differentiation stage during osteoblast maturation involves the downregulation of the Wnt/ß-catenin signaling pathway, and extracellular antagonists are important for the regulation of Wnt signaling. However, the expression levels of Wnt antagonists in these stages of human osteoblast maturation have not been fully elucidated. Therefore, the aim of the present study was to investigate the expression levels of extracellular Wnt antagonists during proliferation and differentiation in osteoblast-like cell lines. The results demonstrated an overlap between the differential expression of secreted Frizzled-related protein (SFPR)2, SFRP3, SFRP4 and Dickkopf (DKK) 2 genes during the differentiation stage in the MG-63 and Saos-2 cells. Furthermore, high expression levels of DKK3 in MG-63 cells, Wnt inhibitory factor 1 (WIF1) in Saos-2 cells and DKK4 in hFOB 1.19 cells during the same stage (differentiation), were observed. The upregulated expression levels of Wnt antagonists were also correlated with the high expression of anxin 2 during the differentiation stage. These findings suggested that Wnt-related antagonists could modulate the Wnt/ß-catenin signaling pathway. By contrast, DKK1 was the only gene that was found to be upregulated during the proliferation stage in hFOB 1.19 and Saos-2 cells. To the best of our knowledge, the present study provides, for the first time, the expression profile of Wnt antagonists during the proliferation stage and the initial phases of differentiation in osteoblast-like cell lines. The current results offer a basis to investigate potential targets for bone-related Wnt-signaling modulation in bone metabolism research.
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Cyrtocarpa procera is a plant used in traditional Mexican medicine to treat different gastrointestinal problems. Here, we investigated the effects of a C. procera methanolic extract in DSS-induced colitis mice. Ulcerative colitis (UC) was induced by administering 4% DSS in drinking water to female BALB/c mice. Compared to untreated mice with UC, the treatment group receiving the C. procera extract presented less severe UC symptoms of diarrhea, bleeding, and weight loss. Additionally, colon shortening was significantly reduced, and at the microscopic level, only minor damage was observed. Levels of proinflammatory cytokines such as TNF-α, IL-1ß, and IFNγ in serum as well as the MPO activity in the colon were significantly reduced in the C. procera methanolic extract-treated group. Moreover, the extract of C. procera reduced oxidative stress during UC, preventing the deterioration of the activity of antioxidant enzymes such as SOD, CAT, and GPx. Additionally, the extract decreased lipid peroxidation damage and its final products, such as malondialdehyde (MDA). In agreement with this, in vitro assays with the C. procera extract displayed good antioxidant capacity, probably due to the presence of polyphenolic compounds, in particular the flavonoids that were identified, such as chrysin, naringenin, kaempferol, and catechin, which have been reported to have anti-inflammatory and antioxidant activities. Therefore, the improvement of UC by the C. procera methanolic extract may be related to the action mechanisms of these compounds.
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Anacardiaceae , Anti-Inflamatórios/uso terapêutico , Antioxidantes/uso terapêutico , Colite Ulcerativa/tratamento farmacológico , Extratos Vegetais/uso terapêutico , Anacardiaceae/química , Animais , Colite Ulcerativa/induzido quimicamente , Colite Ulcerativa/patologia , Colo/patologia , Citocinas/análise , Sulfato de Dextrana , Feminino , Camundongos , Camundongos Endogâmicos BALB C , Peroxidase/metabolismo , Casca de Planta/química , Índice de Gravidade de DoençaRESUMO
Purpose: It has been proposed that DHEA influences bone formation through, bioconversion to 17ß-estradiol; however, DHEA is converted to Δ5-androstenediol (Δ5-Adiol), a metabolite with estrogenic potential involved in diverse biological process. To gain new insight into the role of Δ5-Adiol in bone cells, we examined DHEA and Δ5-Adiol effects in neonatal rat and human hFOB1.19 osteoblasts. Methods: Osteoblast activity was assessed by analyzing proliferation, alkaline phosphatase activity, and expression of OSX and ALPL. We also examined binding affinities for osteoblast-ER and transcriptional activation of human (h)ERα, hERß or hAR in U2-OS cells. Results: The most striking finding was that Δ5-Adiol had greater stimulatory effect than DHEA on rat osteoblast proliferation and differentiation, as well as ALPL expression in human osteoblasts. Interestingly, the Δ5-Adiol or DHEA-induced effects were not precluded with letrozole or trilostane, consistent with bioconversion of DHEA to Δ5-Adiol due to elevated expression of Hsd17b1 in neonatal rat osteoblasts, suggesting a high level of 17ß-hydroxysteroid dehydrogenase type 1 activity. Conversely, Δ5-Adiol and DHEA-induced proliferative effects were inhibited with ICI 182780 alone or combined with trilostane, which correlates with the higher binding affinity of Δ5-Adiol for ER compared to DHEA. Furthermore, Δ5-Adiol showed a greater relative agonist activity for hERα than for hERß or hAR. Conclusion: This study is the first to show that a bioactive DHEA derivative stimulates E2-dependent osteoblast activities, including proliferation and differentiation in rat and human osteoblasts, through ERα-related mechanisms.
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Androstenodiol/farmacologia , Desidroepiandrosterona , Receptor alfa de Estrogênio/agonistas , Osteoblastos/efeitos dos fármacos , 17-Hidroxiesteroide Desidrogenases/metabolismo , Fosfatase Alcalina/metabolismo , Animais , Diferenciação Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Receptor alfa de Estrogênio/metabolismo , Feminino , Humanos , Osteoblastos/metabolismo , Ratos , Ratos WistarRESUMO
MicroRNAs (miRNAs or miRs) are a class of short non-coding RNAs that serve an important regulatory role in living organisms. These molecules are associated with multiple biological processes and are potential biomarkers in multiple diseases. The present study aimed to further identify miRNAs that are differentially expressed in circulating monocytes (CMCs) from postmenopausal Mexican-Mestizo women. Microarray analyses of monocytes using Affymetrix miRNA 4.0 and Human Genome U133 Plus 2.0 arrays were performed in 6 normal and 6 osteoporotic women, followed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) validation. The overexpression of miR-1270, miR-548×-3p and miR-8084 were detected in the osteoporosis compared with the normal group according to the microarray analysis; miR-1270, a miRNA with several target genes associated with bone remodeling, was validated by RT-qPCR. Bioinformatics analysis identified that interferon regulatory factor 8 (IRF8) is the most likely target gene of miR-1270, which is associated with osteoclastogenesis. Furthermore, the findings of the present study demonstrate that an upregulation of miR-1270 may reduce the gene expression of IRF8 in CMCs (osteoclast precursors), implicating its potential role in leading to low bone mineral density and contributing to osteoporosis development in postmenopausal women.
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To identify genetic variants influencing bone mineral density (BMD) in the Mexican-Mestizo population, we performed a GWAS for femoral neck (FN) and lumbar spine (LS) in Mexican-Mestizo postmenopausal women. In the discovery sample, 300,000 SNPs were genotyped in a cohort of 411 postmenopausal women and seven SNPs were analyzed in the replication cohort (n = 420). The combined results of a meta-analysis from the discovery and replication samples identified two loci, RMND1 (rs6904364, P = 2.77 × 10-4) and CCDC170 (rs17081341, P = 1.62 × 10-5), associated with FN BMD. We also compared our results with those of the Genetic Factors for Osteoporosis (GEFOS) Consortium meta-analysis. The comparison revealed two loci previously reported in the GEFOS meta-analysis: SOX6 (rs7128738) and PKDCC (rs11887431) associated with FN and LS BMD, respectively, in our study population. Interestingly, rs17081341 rare in Caucasians (minor allele frequency < 0.03) was found in high frequency in our population, which suggests that this association could be specific to non-Caucasian populations. In conclusion, the first pilot Mexican GWA study of BMD confirmed previously identified loci and also demonstrated the importance of studying variability in diverse populations and/or specific populations.
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A lack of water in livestock production can limit the performance of the animals; therefore, the objective of this study was to evaluate the effect of water restriction on the growth performance of sheep that were fed forage cactus (Nopalea cochenillifera). Forty-two male sheep were used, with an average age and weight of ±100 days and 18.75 ± (2,05) kg , respectively, and they were fed diets containing concentrate, mineral mixture and three levels of substitution (30, 50 and 70%) of Tifton hay with forage cactus (Nopalea cochenillifera). The animals were slaughtered when they reached 32 kg (± 1 kg) of body weight or 90 days. The experimental design was a 3x2 factorial arrangement, forage cactus (30, 50, 70%) x water (with or without water) plus a control group (n=6). Variables were analyzed using Tukey and Dunnett's test at 5% with PROC GLM in SAS software. Voluntary water intake and dry matter intake (DMI) decreased with the inclusion of forage cactus; however, preformed water intake and total water intake increased with the inclusion of forage cactus. Water restriction and its interaction with the treatments had no effect on animal performance. Daily weight gain was higher for the diets with 30 and 50%forage cactus inclusion, at 174 and 155 g, respectively, compared with 90 g for the control diet. Cactus, therefore, can be used as a food supplement and water resource.
A falta de água na produção pecuária pode ser um fator limitante para o bom desempenho dos animais. O objetivo deste trabalho foi avaliar o efeito da restrição total de água na dieta de ovinos, alimentados com palma forrageira sobre o desempenho produtivo. Foram utilizados 42 ovinos, machos, com idade e peso médio de ±100 dias e 18,75± (2,05)kg, respectivamente; alimentados com dietas de 0, 30 50 e 70% de inclusão de palma forrageira. Os animais foram abatidos quando atingiam o peso de 32kg (± 1 kg) ou 90 dias em confinamento. O desenho experimental foi arranjo fatorial 3x2, inclusão de palma (30, 50 70%) x água (com água ou sem água). As variáveis foram analisadas utilizando o teste Tukey a 5% de probabilidade, pelo programa PROC GLM do SAS. Os consumos voluntários de água e de matéria seca diminuíram (P0,05). O ganho de peso diário foi maior para os tratamentos com 30 e 50% de inclusão de palma, com ganhos de 174 e 155 g, respectivamente, comparado com a dieta controle que obteve ganho médio de 90 g. A palma forrageira pode ser utilizada eficientemente como suplemento alimentar e fonte única de água na dieta.
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Animais , Criação de Animais Domésticos , Ingestão de Líquidos , Ovinos/crescimento & desenvolvimento , Aumento de PesoRESUMO
A lack of water in livestock production can limit the performance of the animals; therefore, the objective of this study was to evaluate the effect of water restriction on the growth performance of sheep that were fed forage cactus (Nopalea cochenillifera). Forty-two male sheep were used, with an average age and weight of ±100 days and 18.75 ± (2,05) kg , respectively, and they were fed diets containing concentrate, mineral mixture and three levels of substitution (30, 50 and 70%) of Tifton hay with forage cactus (Nopalea cochenillifera). The animals were slaughtered when they reached 32 kg (± 1 kg) of body weight or 90 days. The experimental design was a 3x2 factorial arrangement, forage cactus (30, 50, 70%) x water (with or without water) plus a control group (n=6). Variables were analyzed using Tukey and Dunnett's test at 5% with PROC GLM in SAS software. Voluntary water intake and dry matter intake (DMI) decreased with the inclusion of forage cactus; however, preformed water intake and total water intake increased with the inclusion of forage cactus. Water restriction and its interaction with the treatments had no effect on animal performance. Daily weight gain was higher for the diets with 30 and 50%forage cactus inclusion, at 174 and 155 g, respectively, compared with 90 g for the control diet. Cactus, therefore, can be used as a food supplement and water resource.(AU)
A falta de água na produção pecuária pode ser um fator limitante para o bom desempenho dos animais. O objetivo deste trabalho foi avaliar o efeito da restrição total de água na dieta de ovinos, alimentados com palma forrageira sobre o desempenho produtivo. Foram utilizados 42 ovinos, machos, com idade e peso médio de ±100 dias e 18,75± (2,05)kg, respectivamente; alimentados com dietas de 0, 30 50 e 70% de inclusão de palma forrageira. Os animais foram abatidos quando atingiam o peso de 32kg (± 1 kg) ou 90 dias em confinamento. O desenho experimental foi arranjo fatorial 3x2, inclusão de palma (30, 50 70%) x água (com água ou sem água). As variáveis foram analisadas utilizando o teste Tukey a 5% de probabilidade, pelo programa PROC GLM do SAS. Os consumos voluntários de água e de matéria seca diminuíram (P<0,05) com a inclusão de palma forrageira nas dietas, porém o consumo de água através dos alimentos e consumo total água aumentaram com a inclusão de palma forrageira (P<0,05). A restrição de água e a interação com os níveis de palma não teve influencia no desempenho dos animais (P>0,05). O ganho de peso diário foi maior para os tratamentos com 30 e 50% de inclusão de palma, com ganhos de 174 e 155 g, respectivamente, comparado com a dieta controle que obteve ganho médio de 90 g. A palma forrageira pode ser utilizada eficientemente como suplemento alimentar e fonte única de água na dieta.(AU)
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Animais , Ovinos/crescimento & desenvolvimento , Ingestão de Líquidos , Criação de Animais Domésticos , Aumento de PesoRESUMO
BACKGROUND: Osteoporosis, a disease characterized by low bone mineral density (BMD), is an important health problem in Mexico. BMD is a highly heritable trait, with heritability estimates of 50-85%. Several candidate genes have been evaluated to identify those involved in BMD variation and the etiology of osteoporosis. This study investigated the possible association of single-nucleotide polymorphisms (SNPs) in the MEF2C, SOST and JAG1genes with bone mineral density (BMD) variation in postmenopausal Mexican-Mestizo women. METHODS: Four hundred unrelated postmenopausal women were included in the study. Risk factors were recorded and BMD was measured in total hip, femoral neck and lumbar spine using dual-energy X-ray absorptiometry. In an initial stage, a total of twenty-five SNPs within or near SOST gene and seven SNPs in the JAG1 gene were genotyped using a GoldenGate assay. In a second stage, three MEF2C gene SNPs were also genotyped and SOST and JAG1 gene variants were validated. Real time PCR and TaqMan probes were used for genotyping. RESULTS: Linear regression analyses adjusted by age, body mass index and ancestry estimates, showed that five SNPs in the SOST gene were significantly associated with BMD in total hip and femoral neck but not lumbar spine. The lowest p value was 0.0012, well below the multiple-test significance threshold (p=0.009), with mean effect size of -0.027 SD per risk allele. We did not find significant associations between BMD and MEF2C/JAG1 gene variants [rs1366594 "A" allele: ß=0.001 (95% CI -0.016; 0.017), P=0.938; rs2273061 "G" allele: ß=0.007 (95% CI -0.007; 0.023), p=0.409]. CONCLUSIONS: SOST polymorphisms may contribute to total hip and femoral neck BMD variation in Mexican postmenopausal women. Together, these and prior findings suggest that this gene may contribute to BMD variation across populations of diverse ancestry.
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Densidade Óssea/genética , Proteínas Morfogenéticas Ósseas/genética , Proteínas de Ligação ao Cálcio/genética , Estudos de Associação Genética , Marcadores Genéticos/genética , Peptídeos e Proteínas de Sinalização Intercelular/genética , Proteínas de Membrana/genética , Pós-Menopausa/genética , Proteínas Adaptadoras de Transdução de Sinal , Idoso , Estudos de Coortes , Feminino , Estudos de Associação Genética/métodos , Humanos , Proteína Jagged-1 , Fatores de Transcrição MEF2/genética , México/etnologia , Pessoa de Meia-Idade , Osteoporose Pós-Menopausa/diagnóstico , Osteoporose Pós-Menopausa/etnologia , Osteoporose Pós-Menopausa/genética , Polimorfismo de Nucleotídeo Único/genética , Pós-Menopausa/etnologia , Proteínas Serrate-JaggedRESUMO
Vanadium concentrations in lung tissue were determined by atomic absorption spectrometry from autopsy specimens taken from residents of Mexico City during the 1960s and 1990s (20 males and 19 females, and 30 males and 18 females, respectively). Samples from the 1990s had significantly increased mean vanadium concentrations (mean +/- standard deviation: 1.36 +/- 0.08), compared with those from the 1960s (1.04 +/- 0.05). Concentrations were not correlated with gender, smoking habit, age, cause of death, or occupation. These findings suggest that vanadium in ambient air is increasing and it represents a potential health hazard for Mexico City residents. Air pollution monitoring efforts should include vanadium concentrations in suspended particles to follow-up the findings reported herein. Researchers need to acquire a better knowledge of the levels of airborne vanadium exposure at which risk to human health occurs.
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Poluentes Atmosféricos/análise , Exposição por Inalação/análise , Pulmão/química , Saúde da População Urbana/estatística & dados numéricos , Saúde da População Urbana/tendências , Vanádio/análise , Adulto , Poluentes Atmosféricos/efeitos adversos , Poluentes Atmosféricos/química , Autopsia , Causas de Morte , Monitoramento Ambiental , Monitoramento Epidemiológico , Feminino , Humanos , Exposição por Inalação/efeitos adversos , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Ocupações/estatística & dados numéricos , Características de Residência/estatística & dados numéricos , Fumar/efeitos adversos , Espectrofotometria Atômica , Vanádio/efeitos adversos , Vanádio/químicaRESUMO
Objetivo. Evaluar la prevalencia de desnutrición que se presentó en niños tabasqueños menores de cinco años en 1996, y su evolución entre 1991 y 1996. Material y métodos. Se realizó un estudio de corte transversal que incluyó a 1 256 niños de 593 comunidades (31 urbanas y 562 rurales) de los 17 municipios de Tabasco. Resultados. El indicador peso/edad registró 41 por ciento de prevalencia de desnutrición, distribuida en leve (26.12 por ciento), moderada (12.62 por ciento) y severa (2.39 por ciento). En niños de entre 1 y 5 años la prevalencia de desnutrición fue de 45 por ciento. Conclusiones. De 1991 a 1996 la cifra de niños con desnutrición ha disminuido proporcionalmente al incremento de la nutrición normal. Asimismo, han disminuido de seis a cuatro los municipios con indicadores críticos de desnutrición, con base en las acciones del sector salud en el estado de Tabasco
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Humanos , Lactente , Pré-Escolar , Criança , Saúde da População Rural/estatística & dados numéricos , Saúde da População Urbana/estatística & dados numéricos , Estado Nutricional , Transtornos da Nutrição Infantil/epidemiologia , Prevalência , México/epidemiologiaRESUMO
Se estudiaron 140 pacientes adultos con anemia drepanocítica. Se encontró úlcera maleolar en 46 enfermos (32,8 %). La región maleolar izquierda fue la zona más afectada (71,6 %). Se establecieron 2 grupos de estudio: 1. Pacientes que recibieron tratamiento con reposo, antibióticos y antisépticos; 2. Enfermos a quienes se les aplicó, además, oxigeno hiperbárico (OHB). No hubo diferencias significativas en las cifras de hemoglobina y reticulocitos ni en el porcentaje de hemoglobina S, entre los grupos estudiados antes y después del OHB. La presión parcial de oxígeno aumentó significativamente y los inmunocomplejos circulantes disminuyeron de manera significativa en los casos del grupo 2. Se demostró insuficiencia valvular venosa en 40 pacientes (86,9 %). En el 100 % de los enfermos se encontraron fenómenos de falciformación en la dermis y en la dermis profunda. Después del tratamiento hubo disminución significativa del tamaño de la úlcera en el 100 % de los casos, pero ésta fue evidente en los enfermos que recibieron OHB. No se detectó ninguna reacción secundaria al uso del OHB
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Adulto , Humanos , Masculino , Feminino , Oxigenoterapia Hiperbárica , Úlcera Cutânea/terapia , Anemia Falciforme/complicações , Anemia Falciforme/terapiaRESUMO
Se estudiaron 140 pacientes adultos con anemia drepanocítica. Se encontró úlcera maleolar en 46 enfermos (32,8 %). La región maleolar izquierda fue la zona más afectada (71,6 %). Se establecieron 2 grupos de estudio: 1. Pacientes que recibieron tratamiento con reposo, antibióticos y antisépticos; 2. Enfermos a quienes se les aplicó, además, oxigeno hiperbárico (OHB). No hubo diferencias significativas en las cifras de hemoglobina y reticulocitos ni en el porcentaje de hemoglobina S, entre los grupos estudiados antes y después del OHB. La presión parcial de oxígeno aumentó significativamente y los inmunocomplejos circulantes disminuyeron de manera significativa en los casos del grupo 2. Se demostró insuficiencia valvular venosa en 40 pacientes (86,9 %). En el 100 % de los enfermos se encontraron fenómenos de falciformación en la dermis y en la dermis profunda. Después del tratamiento hubo disminución significativa del tamaño de la úlcera en el 100 % de los casos, pero ésta fue evidente en los enfermos que recibieron OHB. No se detectó ninguna reacción secundaria al uso del OHB
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Adulto , Humanos , Masculino , Feminino , Anemia Falciforme/complicações , Oxigenoterapia Hiperbárica , Úlcera Cutânea/terapia , Anemia Falciforme/terapiaRESUMO
Se presentan los resultados del estudio de 60 muestras de mucosa endometrial procedentes de legrados diagnósticos realizados a pacientes con DIUC implantado. El tiempo de implantación fue variado, desde unos meses hasta nueve años. Se discute la posibilidad de que estos cambios manifiesten una respuesta inmunológica de la mucosa endometrial(AU)